3.4.17.1: carboxypeptidase A

This is an abbreviated version!
For detailed information about carboxypeptidase A, go to the full flat file.

Reaction

release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro =

Synonyms

A-type metallocarboxypeptidase, AcCP, Anson's enzyme, ASPA, aspartoacyclase, carboxypeptidase, carboxypeptidase a, carboxypeptidase A-6, carboxypeptidase A-like activity, carboxypeptidase A1, carboxypeptidase A2, Carboxypeptidase A3, carboxypeptidase A4, carboxypeptidase vitellogenic-like, carboxypeptidase-A, carboxypolypeptidase, colon mast cell carboxypeptidase, CPA, CPA1, CPA3, CPA4, CPA6, CPAI, CPD, CPVL, EC 3.4.12.2, EC 3.4.2.1, hCPA, hCPA4, mast cell carboxypeptidase A, mast cell CPA, mast cell-CPA, mast-cell carboxypeptidase A, mast-cell CPA, MC-CP, MC-CPA, MCCPA, MCP-2, mCPA, MDCP-A1, MDCP-A2, MeCPA, MF-CPA, molting carboxypeptidase A, molting fluid carboxypeptidase A, More, Nna1/CCP1, ochratoxin A hydrolytic enzyme, PTD012, RMC-CP, vitellogenic-like carboxypeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.17 Metallocarboxypeptidases

                3.4.17.1 carboxypeptidase A

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Results	in table
20	Activating Compound
121	AA Sequence
32	Application
2	CAS Registry Number
30	Cloned(Commentary)
31	Crystallization (Commentary)
6802	Disease/ Diagnostics
8	Expression
4	General Information
9	General Stability
8	IC50 Value
325	Inhibitors
12	kcat/KM [mM/s]
177	Ki Value [mM]
105	KM Value [mM]
28	Localization
87	Metals/Ions
58	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
172	Organism
62	PDB ID
53	pH Optimum
13	pH Range
9	pH Stability
15	pI Value
9	Posttranslational Modification
40	Protein Variants
37	Purification (Commentary)
27	Reaction
27	Reaction Type
168	Reference
2	Renatured (Commentary)
168	Source Tissue
36	Specific Activity [micromol/min/mg]
9	Storage Stability
232	Substrates and Products (Substrate)
25	Subunits
156	Synonyms
35	Temperature Optimum [°C]
1	Temperature Range [°C]
12	Temperature Stability [°C]
90	Turnover Number [1/s]

General Stability

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General Stability on EC 3.4.17.1 - carboxypeptidase A

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

effect of ionic strength: marked decrease of activity above 150 mM NaCl

Homo sapiens

-

36329

freezing destabilizes, unstable in 0.72 M (NH4)2SO4, stable in 2.1 M (NH4)2SO4

Sus scrofa

-

36338

generally unstable at all stages of purification

Rattus norvegicus

-

36324

hydrophobic environment of immobilized enzyme enhances conformational stability

Bos taurus

-

36354

immobilization on acid chloride or oxidised cellulose increases half-life from 20 min to 168 min

Capra hircus

-

36351

little effect of urea on enzyme activity

Sus scrofa

-

36335

no effect of freezing and thawing

Penaeus setiferus

-

36330

unstable upon lyophilization

Sus scrofa

-

36338

urea influences general stability, 4 M, 0°C, pH 7.5, 24 h, stable, 7 M, 0°C, pH 7.5, 24 h, unstable

Bos taurus

-

36322