Reference on EC 3.4.17.1 - carboxypeptidase A
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ludwig, M.
Carboxypeptidase A and other peptidases
Inorg. Biochem.
1
438-487
1973
Bos taurus, Squalus acanthias
-
Christianson, D.W.; Lipscomb, D.W.
Carboxypeptidase A
Acc. Chem. Res.
22
62-69
1989
Bos taurus
-
Riordan, J.F.; Holmquist, B.
Carboxypeptidase A
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
5
44-55
1984
Bos taurus, Homo sapiens
-
Appel, W.
Carboxypeptidasen
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
1
1023-1037
1974
Bos taurus, Homo sapiens, Rattus norvegicus
-
Petra, P.H.
Bovine procarboxypeptidase and carboxypeptidase A
Methods Enzymol.
19
460-503
1970
Bos taurus
-
Serafin, W.E.; Dayton, E.T.; Gravallese, P.M.; Austen, K.F.; Stevens, R.L.
Carboxypeptidase A in mouse mast cells. Identification, characterization, and use as a differentiation marker
J. Immunol.
139
3771-3776
1987
Mus musculus
Bodwell, J.E.; Meyer, W.L.
Purification and characterization of carboxypeptidase A from rat skeletal muscle
Biochemistry
20
2767-2777
1981
Rattus norvegicus
Everitt, M.T.; Neurath, H.
Rat peritoneal mast cell carboxypeptidase: localization, purification, and enzymatic properties
FEBS Lett.
110
292-296
1980
Rattus norvegicus
Hass, G.M.
Purification and partial characterization of a carboxypeptidase from the limpet (Patella vulgata)
Arch. Biochem. Biophys.
198
247-254
1979
Patella vulgata
Oshima, G.; Nagasawa, K.
Purification of carboxypeptidase A using Sepharose 4B-bound 3-phenylpropionate
J. Biochem.
81
1285-1291
1977
Bos taurus
Spilburg, C.A.; Bethune, J.L.; Vallee, B.L.
Kinetic properties of crystalline enzymes. Carboxypeptidase A
Biochemistry
16
1142-1150
1977
Bos taurus
Peterson, L.M.; Sokolovsky, M.; Vallee, B.L.
Purification and crystallization of human carboxypeptidase A
Biochemistry
15
2501-2508
1976
Homo sapiens
Gates, B.J.; Travis, J.
Purification and characterization of carboxypeptidases A and B from the white shrimp (Penaeus setiferus)
Biochemistry
12
1867-1874
1973
Penaeus setiferus
Reeck, G.R.; Walsh, K.A.; Neurath, H.
Isolation and characterization of carboxypeptidases A and B from activated pancreatic juice
Biochemistry
10
4690-4698
1971
Bos taurus
Petra, P.H.; Neurath, H.
Heterogeneity of bovine carboxypeptidase A. II. Chromatographic purification of carboxypeptidase A (Cox)
Biochemistry
8
5029-5036
1969
Bos taurus
Petra, P.H.; Neurath, H.
The heterogeneity of bovine carboxypeptidase A. I. The chromatographic purification of carboxypeptidase A (Anson)
Biochemistry
8
2466-2475
1969
Bos taurus
Lacko, A.G.; Neurath, H.
Studies on procarboxypeptidase A of the spiny pacific dogfish (Squalus acanthias)
Biochemistry
9
4680-4690
1976
Squalus acanthias
Folk, J.E.; Schirmer, E.W.
The porcine pancreatic carboxypeptidase A system
J. Biol. Chem.
238
3884-3894
1963
Sus scrofa
Clauser, E.; Gardell, S.J.; Craik, C.S.; MacDonald, R.J.; Rutter, W.J.
Structural characterization of the rat carboxypeptidase A1 and B genes. Comparative analysis of the rat carboxypeptidase gene family
J. Biol. Chem.
263
17837-17845
1988
Rattus norvegicus
Koide, A.; Yoshizawa, M.; Kurachi, K.
Crystallization and properties of carboxypeptidase A gamma from porcine pancreas
Eur. J. Biochem.
117
383-388
1981
Sus scrofa
Shoham, G.; Rees, D.C.; Lipscomb, W.M.
Effects of pH on the structure and function of carboxypeptidase A: crystallographic studies
Proc. Natl. Acad. Sci. USA
81
7767-7771
1984
Bos taurus
Auld, D.S.; Vallee, B.L.
Kinetics of carboxypeptidase A. II. Inhibitors of the hydrolysis of oligopeptides
Biochemistry
9
602-609
1970
Bos taurus
Lipscomb, W.N.
Relationship of the three-dimensional structure of carboxypeptidase A to catalysis
Tetrahedron
30
1725-1732
1974
Bos taurus
-
Homandberg, G.A.; Peanasky, R.J.
Characterization of proteins from Ascaris lumbricoides which bind specifically to carboxypeptidase
J. Biol. Chem.
251
2226-2233
1976
Bos taurus, Sus scrofa
Birk, Y.
Proteinase inhibitors from potatoes
Methods Enzymol.
45
728-739
1976
Bos taurus
Lipscomb, W.N.
Carboxypeptidase A mechanisms
Proc. Natl. Acad. Sci. USA
77
3875-3878
1980
Bos taurus
Rees, D.C.; Lewis, M.; Honzatko, R.B.; Lipscomb, W.M.; Hardman, K.D.
Zinc environment and cis peptide bonds in carboxypeptidase A at 1.75-A resolution
Proc. Natl. Acad. Sci. USA
78
3408-3412
1981
Bos taurus
Ault, D.S.; Galdes, A.; Geoghegan, K.F.; Holmquist, B.; Martinelli, R.A.; Vallee, B.L.
Cryospectrokinetic characterization of intermediates in biochemical reactions: carboxypeptidase A
Proc. Natl. Acad. Sci. USA
81
5041-5045
1984
Bos taurus
Nowak, E.; Dabrowska, R.
Properties of carboxypeptidase A-treated chicken gizzard tropomyosin
Biochim. Biophys. Acta
829
335-341
1985
Bos taurus
Kilmartin, J.V.
Removal of specific C-terminal residues from human hemoglobin using carboxypeptidases A and B
Methods Enzymol.
76
167-171
1981
Bos taurus
Mock, W.L.; Tsay, J.T.
pK Values for active site residues of carboxypeptidase A
J. Biol. Chem.
263
8635-8641
1988
Bos taurus
Gettins, P.
On the coordination of inhibitors to the metal ion of carboxypeptidase A. A 113Cd and 31P NMR study
J. Biol. Chem.
261
15513-15518
1986
Bos taurus
Kumar, S.; Vasudevan, P.; Dua, R.D.
Activity of carboxypeptidase A bound to a modified cellulosic matrix
Appl. Biochem. Biotechnol.
12
107-119
1986
Capra hircus
-
Suh, J.; Cho, W.; Chung, S.
Carboxypeptidase A-catalysed hydrolysis of alpha-(acylamino)cinnamoyl derivatives of L-beta-phenyllactate and L-phenylalaninate: evidence for acyl-enzyme intermediates
J. Am. Chem. Soc.
107
4530-4535
1985
Bos taurus
-
Lee, K.J.; Kim, D.H.
Design of mechanism-based carboxypeptidase A inactivators on the basis of the X-ray crystal structure and catalytic reaction pathway
Bioorg. Med. Chem.
6
1613-1622
1998
Bos taurus
Vertesi, A.; Simon, L.M.; Kiss, I.; Szajani, B.
Preparation, characterization and application of immobilized carboxypeptidase A
Enzyme Microb. Technol.
25
73-79
1999
Bos taurus
-
Asante-Appiah, E.; Chan, W.C.
Analysis of the interactions between an enzyme and multiple inhibitors using combination plots
Biochem. J.
320
17-26
1996
Bos taurus
Zenchenko, T.A.; Morozov, V.N.
Mechanical deformation enhances catalytic activity of crystalline carboxypeptidase A
Protein Sci.
4
251-257
1995
Bos taurus
Mock, W.L.; Wang, L.
Synergistic inhibition of carboxypeptidase A by zinc ion and imidazole
Biochem. Biophys. Res. Commun.
257
239-243
1999
Bos taurus
Weizetfel, J.C.; Smania, A.M.; Barra, H.S.; Argarana, C.E.
A brain protein (P30) that immunoreacts with a polyclonal anti-pancreatic carboxypeptidase A antibody shows properties that are shared with tubulin carboxypeptidase
Mol. Cell. Biochem.
170
139-146
1997
Bos taurus
Banci, L.; Schroeder, S.; Kollman, P.A.
Molecular dynamics characterization of the active cavity of carboxypeptidase A and some of its inhibitor adducts
Proteins
13
288-305
1992
Bos taurus
Bradley, G.; Naude, R.J.; Muramoto, K.; Yamauchi, F.; Oeloefsen, W.
Ostrich (Struthio camelus) carboxypeptidase A: purification, kinetic properties and characterization of the pancreatic enzyme
Int. J. Biochem.
26
555-564
1994
Struthio camelus
Chai, J.J.; He, C.H.; Li, M.; Tang, L.; Ming, L.
Crystal structure of carboxypeptidase A complexed with an inactivator in two crystal forms
Protein Eng.
11
841-845
1998
Bos taurus
Zhang, K.; Chance, B.
X-ray absorption fine structure study of the active site of zinc and cobalt carboxypeptidase A in their solution and crystalline forms
Biochemistry
31
1159-1168
1992
Bos taurus
Auld, D.S.; Bertini, I.; Donaire, A.; Messori, L.; Moratal, J.M.
pH-dependent properties of cobalt(II) carboxypeptidase A-inhibitor complexes
Biochemistry
31
3840-3846
1992
Bos taurus
Larsen, K.S.; Auld, D.S.
Carboxypeptidase A: mechanism of zinc inhibition
Biochemistry
28
9620-9625
1989
Bos taurus
Kim, H.; Lipscomb, N.
Comparison of the structures of three carboxypeptidase A-phosphonate complexes determined by X-ray crystallography
Biochemistry
30
8171-8180
1991
Bos taurus
Gardell, S.J.; Craik, C.S.; Clauser, E.; Goldsmith, E.J.; Stewart, C.B.; Graf, M.; Rutter, W.J.
A novel rat carboxypeptidase, CPA2: characterization, molecular cloning, and evolutionary implications on substrate specificity in the carboxypeptidase gene family
J. Biol. Chem.
263
17828-17836
1988
Rattus norvegicus
Kilshtain-Vardi, A.; Glick, M.; Greenblatt, H.M.; Goldblum, A.; Shoham, G.
Refined structure of bovine carboxypeptidase A at 1.25 A resolution
Acta Crystallogr. Sect. D
59
323-333
2003
Bos taurus
van Aalten, D.M.F.; Chong, C.R.; Joshua-Tor, L.
Crystal structure of carboxypeptidase A complexed with D-cysteine at 1.75.ANG. - Inhibitor-induced conformational changes
Biochemistry
39
10082-10089
2000
Bos taurus (P00730)
Mock, W.L.; Cheng, H.
Principles of hydroxamate inhibition of metalloproteases: carboxypeptidase A
Biochemistry
39
13945-13952
2000
Bos taurus
Chong, C.R.; Auld, D.S.
Inhibition of carboxypeptidase A by D-penicillamine: mechanism and implications for drug design
Biochemistry
39
7580-7588
2000
Bos taurus
Cho, J.H.; Kim, D.H.; Lee, K.J.; Choi, K.Y.
The role of Tyr248 probed by mutant bovine carboxypeptidase A: insight into the catalytic mechanism of carboxypeptidase A
Biochemistry
40
10197-10203
2001
Bos taurus
Cho, J.H.; Kim, D.H.; Chung, S.J.; Ha, N.C.; Oh, B.H.; Yong Choi, K.
Insight into the stereochemistry in the inhibition of carboxypeptidase A with N-(hydroxyaminocarbonyl)phenylalanine: binding modes of an enantiomeric pair of the inhibitor to carboxypeptidase A
Bioorg. Med. Chem.
10
2015-2022
2002
Bos taurus (P00730)
Lee, M.; Kim, D.H.
Syntheses and kinetic evaluation of racemic and optically active 2-benzyl-2-methyl-3,4-epoxybutanoic acids as irreversible inactivators for carboxypeptidase A
Bioorg. Med. Chem.
10
913-922
2002
Bos taurus
Jin, J.Y.; Tian, G.R.; Kim, D.H.
Optically active 2-benzyl-3-methanesulfinylpropanoic acid: Synthesis and evaluation as inhibitors for carboxypeptidase A
Bioorg. Med. Chem.
11
4377-4381
2003
Bos taurus
Lee, H.S.; Kim, D.H.
Synthesis and evaluation of alpha,alpha-disubstituted-3-mercaptopropanoic acids as inhibitors for carboxypeptidase A and implications with respect to enzyme inhibitor design
Bioorg. Med. Chem.
11
4685-4691
2003
Bos taurus
Park, J.D.; Kim, D.H.
Sulfamide derivatives as transition state analogue inhibitors for carboxypeptidase A
Bioorg. Med. Chem.
12
2349-2356
2004
Bos taurus, Homo sapiens
Lee, M.; Kim, D.H.
Hippuryl-alpha-methylphenylalanine and hippuryl-alpha-methylphenyllactic acid as substrates for carboxypeptidase A. Syntheses, kinetic evaluation and mechanistic implication
Bioorg. Med. Chem.
8
815-823
2000
Bos taurus
Chung, S.J.; Kim, D.H.
N-(Hydroxyaminocarbonyl)phenylalanine: a novel class of inhibitor for carboxypeptidase A
Bioorg. Med. Chem.
9
185-189
2001
Bos taurus
Park, J.D.; Lee, K.J.; Kim, D.H.
A new inhibitor design strategy for carboxypeptidase A as exemplified by N-(2-chloroethyl)-N-methylphenylalanine
Bioorg. Med. Chem.
9
237-243
2001
Bos taurus
Marino-Buslje, C.; Venhudova, G.; Molina, M.A.; Oliva, B.; Jorba, X.; Canals, F.; Aviles, F.X.; Querol, E.
Contribution of C-tail residues of potato carboxypeptidase inhibitor to the binding to carboxypeptidase A A mutagenesis analysis
Eur. J. Biochem.
267
1502-1509
2000
Bos taurus
Park, J.D.; Kim, D.H.; Kim, S.J.; Woo, J.R.; Ryu, S.E.
Sulfamide-based inhibitors for carboxypeptidase A. Novel type transition state analogue inhibitors for zinc proteases
J. Med. Chem.
45
5295-5302
2002
Bos taurus (P00730)
Park, J.D.; Kim, D.H.
Cysteine derivatives as inhibitors for carboxypeptidase A: synthesis and structure-activity relationships
J. Med. Chem.
45
911-918
2002
Bos taurus
Chung, S.J.; Chung, S.; Lee, H.S.; Kim, E.J.; Oh, K.S.; Choi, H.S.; Kim, K.S.; Kim, Y.J.; Hahn, J.H.; Kim, D.H.
Mechanistic insight into the inactivation of carboxypeptidase A by alpha-benzyl-2-oxo-1,3-oxazolidine-4-acetic acid, a novel type of irreversible inhibitor for carboxypeptidase A with no stereospecificity
J. Org. Chem.
66
6462-6471
2001
Bos taurus
Robertson, A.J.; Conrad, V.; Moraes, G.
Stabilization of carboxypeptidases in acid extracts of ovine pancreas
Process Biochem.
39
615-621
2004
Ovis aries
-
Shimada, H.; Funakoshi, T.; Waalkes, M.P.
Acute, nontoxic cadmium exposure inhibits pancreatic protease activities in the mouse
Toxicol. Sci.
53
474-480
2000
Mus musculus
Shibata, T.; Motomura, J.; Yamaguchi, K.; Kiriyama, T.; Fujii, A.; Hama, Y.; Nakamura, T.
Distribution of digestive enzymes in the rabbitfish Siganus fuscescens
ITE Lett. Batteries New Technol. Med.
6
368-371
2005
Siganus fuscescens
-
Laethem, R.M.; Blumenkopf, T.A.; Cory, M.; Elwell, L.; Moxham, C.P.; Ray, P.H.; Walton, L.M.; Smith, G.K.
Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2
Arch. Biochem. Biophys.
332
8-18
1996
Homo sapiens
Uratani, Y.; Takiguchi-Hayashi, K.; Miyasaka, N.; Sato, M.; Jin, M.; Arimatsu, Y.
Latexin, a carboxypeptidase A inhibitor, is expressed in rat peritoneal mast cells and is associated with granular structures distinct from secretory granules and lysosomes
Biochem. J.
346
817-826
2000
Rattus norvegicus
Arolas, J.L.; Lorenzo, J.; Rovira, A.; Vendrell, J.; Aviles, F.X.; Ventura, S.
Secondary binding site of the potato carboxypeptidase inhibitor. Contribution to its structure, folding, and biological properties
Biochemistry
43
7973-7982
2004
Bos taurus
Eriyamremu, G.E.; Asagba, S.O.; Onyeneke, E.C.; Adaikpoh, M.A.
Changes in carboxypeptidase A, dipeptidase and Na+/K+ ATPase activities in the intestine of rats orally exposed to different doses of cadmium
Biometals
18
1-6
2005
Rattus norvegicus
Jamur, M.C.; Grodzki, A.C.; Berenstein, E.H.; Hamawy, M.M.; Siraganian, R.P.; Oliver, C.
Identification and characterization of undifferentiated mast cells in mouse bone marrow
Blood
105
4282-4289
2005
Mus musculus
Fontenele-Neto, J.D.; Kalinina, E.; Feng, Y.; Fricker, L.D.
Identification and distribution of mouse carboxypeptidase A-6
Brain Res. Mol. Brain Res.
137
132-142
2005
Mus musculus (Q5U901), Mus musculus
Song, J.B.; Hah, S.S.; Suh, J.
Cyclen-containing inhibitors of carboxypeptidase A synthesized in search of target-selective artificial proteases
Bull. Korean Chem. Soc.
25
1703-1706
2004
Bos taurus
-
Reznik, S.E.; Fricker, L.D.
Carboxypeptidases from A to Z: implications in embryonic development and Wnt binding
Cell. Mol. Life Sci.
58
1790-1804
2001
Mammalia
Srivastava, A.S.; Kurokawa, T.; Suzuki, T.
Molecular cloning and cDNA sequence analysis of carboxypeptidases A1, A2 and B from the Japanese flounder Paralichthys olivaceus
Comp. Biochem. Physiol. B
135
593-599
2003
Paralichthys olivaceus (Q8AXN4)
Ote, M.; Mita, K.; Kawasaki, H.; Daimon, T.; Kobayashi, M.; Shimada, T.
Identification of molting fluid carboxypeptidase A (MF-CPA) in Bombyx mori
Comp. Biochem. Physiol. B
141B
314-322
2005
Bombyx mori (Q60F93), Bombyx mori
Kim, D.H.
Chemistry-based design of inhibitors for carboxypeptidase A
Curr. Top. Med. Chem.
4
1217-1226
2004
Bos taurus
Montesdeoca, M.; Lobo, M.G.; Casanas, N.; Camero, A.; Castanera, P.; Ortego, F.
Partial characterization of the proteolytic enzymes in the gut of the banana weevil, Cosmopolites sordidus, and effects of soybean Kunitz trypsin inhibitor on larval performance
Entomol. Exp. Appl.
116
227-236
2005
Cosmopolites sordidus
Wang, P.; Li, G.; Kain, W.
Characterization and cDNA cloning of midgut carboxypeptidases from Trichoplusia ni
Insect Biochem. Mol. Biol.
34
831-843
2004
Trichoplusia ni
Liu, X.; Fellers, J.P.; Zhu, Y.C.; Mutti, N.S.; El-Bouhssini, M.; Chen, M.S.
Cloning and characterization of cDNAS encoding carboxypeptidase-like proteins from the gut of Hessian fly larvae Mayetiola destructor (Say)
Insect Biochem. Mol. Biol.
36
665-673
2006
Mayetiola destructor (Q0QWG2), Mayetiola destructor (Q0QWG3), Mayetiola destructor (Q0QWG4), Mayetiola destructor (Q0QWG5), Mayetiola destructor (Q0QWG6), Mayetiola destructor (Q0QWG7), Mayetiola destructor
Deckert, P.M.; Bornmann, W.G.; Ritter, G.; Williams, C.; Franke, J.; Keilholz, U.; Thiel, E.; Old, L.J.; Bertino, J.R.; Welt, S.
Specific tumour localisation of a huA33 antibody-carboxypeptidase A conjugate and activation of methotrexate-phenylalanine
Int. J. Oncol.
24
1289-1295
2004
Homo sapiens
Henningsson, F.; Yamamoto, K.; Saftig, P.; Reinheckel, T.; Peters, C.; Knight, S.D.; Pejler, G.
A role for cathepsin E in the processing of mast-cell carboxypeptidase A
J. Cell Sci.
118
2035-2042
2005
Mus musculus
Wentland, M.P.; Raza, S.; Gao, Y.
96-well plate colorimetric assay for Ki determination of (+-)-2-benzylsuccinic acid, an inhibitor of carboxypeptidase A: a laboratory experiment in drug discovery
J. Chem. Educ.
81
398-400
2004
Mammalia
-
Reynolds, D.S.; Gurley, D.S.; Austen, K.F.
Cloning and characterization of the novel gene for mast cell carboxypeptidase A
J. Clin. Invest.
89
273-282
1992
Homo sapiens (P15088), Homo sapiens
Arolas, J.L.; Popowicz, G.M.; Lorenzo, J.; Sommerhoff, C.P.; Huber, R.; Aviles, F.X.; Holak, T.A.
The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode
J. Mol. Biol.
350
489-498
2005
Bos taurus (P00730), Bos taurus
Arolas, J.L.; Popowicz, G.M.; Bronsoms, S.; Aviles, F.X.; Huber, R.; Holak, T.A.; Ventura, S.
Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond
J. Mol. Biol.
352
961-975
2005
Bos taurus
Phoon, L.; Burton, N.A.
Assessment of a mechanism for reactive inhibition of carboxypeptidase A with QM/MM methods
J. Mol. Graph. Model.
24
94-101
2005
Bos taurus
Dominguez-Munoz, J.E.; Martinez, S.M.; Leodolter, A.; Malfertheiner, P.
Quantification of pancreatic zinc output as pancreatic function test: making the secretin-caerulein test applicable to clinical practice
Pancreatology
4
57-62
2004
Homo sapiens
Pallares, I.; Bonet, R.; Garcia-Castellanos, R.; Ventura, S.; Aviles, F.X.; Vendrell, J.; Gomis-Rueth, F.X.
Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin
Proc. Natl. Acad. Sci. USA
102
3978-3983
2005
Homo sapiens
Mouradov, D.; Craven, A.; Forwood, J.K.; Flanagan, J.U.; Garcia-Castellanos, R.; Gomis-Rueth, F.X.; Hume, D.A.; Martin, J.L.; Kobe, B.; Huber, T.
Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking
Protein Eng. Des. Sel.
19
9-16
2006
Bos taurus (P00730)
El-Ebiarie, A.S.; Taha, N.; Abd El-Meguid, A.; Mustafa, M.A.
A preliminary characterization of digestive protease in the midgut of the third larval instar of Gasterophilus intestinalis
Vet. Med. J. Giza
53
5-23
2005
Gasterophilus intestinalis
-
Chen, Z.Q.; He, S.H.
Cloning and expression of human colon mast cell carboxypeptidase
World J. Gastroenterol.
10
342-347
2004
Homo sapiens
Bayes, A.; Fernandez, D.; Sola, M.; Marrero, A.; Garcia-Pique, S.; Aviles, F.X.; Vendrell, J.; Gomis-Rueth, F.X.
Caught after the act: a human A-type metallocarboxypeptidase in a product complex with a cleaved hexapeptide
Biochemistry
46
6921-6930
2007
Homo sapiens (Q9UI42), Homo sapiens
Hershfield, J.R.; Pattabiraman, N.; Madhavarao, C.N.; Namboodiri, M.A.
Mutational analysis of aspartoacylase: implications for Canavan disease
Brain Res.
1148
1-14
2007
Homo sapiens
Garabelli, P.J.; Modrall, J.G.; Penninger, J.M.; Ferrario, C.M.; Chappell, M.C.
Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart
Exp. Physiol.
93
613-621
2008
Mus musculus
Peteri, Z.; Teren, J.; Vagvoelgyi, C.; Varga, J.
Ochratoxin degradation and adsorption caused by astaxanthin-producing yeasts
Food Microbiol.
24
205-210
2007
Phaffia rhodozyma
Dorrah, M.A.; El-Bassiony, G.M.
Identification of digestive hydrolases in the larval midgut of the camel nasal bot fly Cephalopina titillator Clark (Diptera: Oestridae)
J. Egypt. Soc. Parasitol.
37
541-556
2007
Cephalopina titillator
Schneider, L.A.; Schlenner, S.M.; Feyerabend, T.B.; Wunderlin, M.; Rodewald, H.R.
Molecular mechanism of mast cell mediated innate defense against endothelin and snake venom sarafotoxin
J. Exp. Med.
204
2629-2639
2007
Mus musculus
Geoffrey, R.; Jia, S.; Kwitek, A.E.; Woodliff, J.; Ghosh, S.; Lernmark, A.; Wang, X.; Hessner, M.J.
Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the BioBreeding rat
J. Immunol.
177
7275-7286
2006
Rattus norvegicus, Rattus norvegicus (P00731)
Pejler, G.; Aabrink, M.; Ringvall, M.; Wernersson, S.
Mast cell proteases
Adv. Immunol.
95
167-255
2007
Homo sapiens, Mus musculus, Rattus norvegicus
Hennig, A.; Florea, M.; Roth, D.; Enderle, T.; Nau, W.M.
Design of peptide substrates for nanosecond time-resolved fluorescence assays of proteases: 2,3-Diazabicyclo[2.2.2]oct-2-ene as a noninvasive fluorophore
Anal. Biochem.
360
255-265
2007
Bos taurus
Braga, T.; Grujic, M.; Lukinius, A.; Hellman, L.; Abrink, M.; Pejler, G.
Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells
Biochem. J.
403
49-57
2007
Mus musculus
Mustafi, D.; Smith, C.M.; Makinen, M.W.; Lee, R.C.
Multi-block poloxamer surfactants suppress aggregation of denatured proteins
Biochim. Biophys. Acta
1780
7-15
2008
Bos taurus
Ke, S.; Wright, J.C.; Kwon, G.S.
Avidin-biotin-PEG-CPA complexes as potential EPR-directed therapeutic protein carriers: preparation and characterization
Bioconjug. Chem.
18
1644-1650
2007
Bos taurus
Abrunhosa, L.; Venancio, A.
Isolation and purification of an enzyme hydrolyzing ochratoxin A from Aspergillus niger
Biotechnol. Lett.
29
1909-1914
2007
Aspergillus niger
Schmidt, D.; Brennan, S.O.
Modified form of the fibrinogen Bbeta chain (des-Gln Bbeta), a potential long-lived marker of pancreatitis
Clin. Chem.
53
2105-2111
2007
Bos taurus
Matsugi, S.; Hamada, T.; Shioi, N.; Tanaka, T.; Kumada, T.; Satomura, S.
Serum carboxypeptidase A activity as a biomarker for early-stage pancreatic carcinoma
Clin. Chim. Acta
378
147-153
2007
Homo sapiens
Bernkop-Schnuerch, A.; Schmitz, T.
Presystemic metabolism of orally administered peptide drugs and strategies to overcome it
Curr. Drug Metab.
8
509-517
2007
Homo sapiens
Yamamoto, T.; Yamato, E.; Taniguchi, H.; Shimoda, M.; Tashiro, F.; Hosoi, M.; Sato, T.; Fujii, S.; Miyazaki, J.
Stimulation of cAMP signaling allows isolation of clonal pancreatic precursor cells from adult mouse pancreas
Diabetologia
49
2359-2367
2006
Mus musculus
Bonferoni, M.C.; Sandri, G.; Rossi, S.; Ferrari, F.; Gibin, S.; Caramella, C.
Chitosan citrate as multifunctional polymer for vaginal delivery. Evaluation of penetration enhancement and peptidase inhibition properties
Eur. J. Pharm. Sci.
33
166-176
2008
Bos taurus, Sus scrofa
Pedroche, J.; Yust, M.M.; Lqari, H.; Megias, C.; Giron-Calle, J.; Alaiz, M.; Vioque, J.; Millan, F.
Obtaining of Brassica carinata protein hydrolysates enriched in bioactive peptides using immobilized digestive proteases
Food Res. Int.
40
931-938
2007
Bos taurus
Prabhakar, S.; Chen, M.; Elpidina, E.N.; Vinokurov, K.S.; Smith, C.M.; Marshall, J.; Oppert, B.
Sequence analysis and molecular characterization of larval midgut cDNA transcripts encoding peptidases from the yellow mealworm, Tenebrio molitor L
Insect Mol. Biol.
16
455-468
2007
Tenebrio molitor (A1XG97), Tenebrio molitor (A1XG98), Tenebrio molitor (A1XG99), Tenebrio molitor (A1XGA0), Tenebrio molitor (A1XGA1), Tenebrio molitor (A1XGA2), Tenebrio molitor (A1XGA3), Tenebrio molitor
Pedroche, J.; Yust, M.d.e.l.M.; Lqari, H.; Megias, C.; Giron-Calle, J.; Alaiz, M.; Vioque, J.; Millan, F.
Production of Brassica carinata protein hydrolyzates with a high Fischers ratio using immobilized proteases
J. Agric. Food Chem.
54
7621-7627
2006
Bos taurus
Yanes, O.; Aviles, F.X.; Roepstorff, P.; J?rgensen, T.J.
Exploring the "intensity fading" phenomenon in the study of noncovalent interactions by MALDI-TOF mass spectrometry
J. Am. Soc. Mass Spectrom.
18
359-367
2007
Bos taurus
Chong, C.R.; Auld, D.S.
Catalysis of zinc transfer by D-penicillamine to secondary chelators
J. Med. Chem.
50
5524-5527
2007
Bos taurus
Yanes, O.; Nazabal, A.; Wenzel, R.; Zenobi, R.; Aviles, F.X.
Detection of noncovalent complexes in biological samples by intensity fading and high-mass detection MALDI-TOF mass spectrometry
J. Proteome Res.
5
2711-2719
2006
Homo sapiens
Hao, X.K.; Liu, J.Y.; Yue, Q.H.; Wu, G.J.; Bai, Y.J.; Yin, Y.
In vitro and in vivo prodrug therapy of prostate cancer using anti-gamma-Sm-scFv/hCPA fusion protein
Prostate
66
858-866
2006
Homo sapiens
Cowieson, N.P.; Miles, A.J.; Robin, G.; Forwood, J.K.; Kobe, B.; Martin, J.L.; Wallace, B.A.
Evaluating protein:protein complex formation using synchrotron radiation circular dichroism spectroscopy
Proteins
70
1142-1146
2008
Bos taurus
Niemirowicz, G.; Parussini, F.; Agueero, F.; Cazzulo, J.J.
Two metallocarboxypeptidases from the protozoan Trypanosoma cruzi belong to the M32 family, found so far only in prokaryotes
Biochem. J.
401
399-410
2007
Trypanosoma cruzi (Q6ZXB9)
Kalinina, E.; Biswas, R.; Berezniuk, I.; Hermoso, A.; Aviles, F.X.; Fricker, L.D.
A novel subfamily of mouse cytosolic carboxypeptidase
FASEB J.
21
836-850
2007
Homo sapiens, Mus musculus, Mus musculus C57B6
Harris, J.; Schwinn, N.; Mahoney, J.A.; Lin, H.; Shaw, M.; Howard, C.J.; da Silva, R.P.; Gordon, S.
A vitellogenic-like carboxypeptidase expressed by human macrophages is localized in endoplasmic reticulum and membrane ruffles
Int. J. Exp. Pathol.
87
29-39
2006
Candida albicans, Homo sapiens
Manjasetty, B.A.; Buessow, K.; Fieber-Erdmann, M.; Roske, Y.; Gobom, J.; Scheich, C.; Goetz, F.; Niesen, F.H.; Heinemann, U.
Crystal structure of Homo sapiens PTD012 reveals a zinc-containing hydrolase fold
Protein Sci.
15
914-920
2006
Homo sapiens
Masuhara, M.; Sato, T.; Hada, N.; Hakeda, Y.
Protective protein/cathepsin A down-regulates osteoclastogenesis by associating with and degrading NF-kappaB p50/p65
J. Bone Miner. Metab.
27
46-56
2009
Bos taurus
Wang, S.F.; Tian, G.R.; Zhang, W.Z.; Jin, J.Y.
Characterization of alpha-nitromethyl ketone as a new zinc-binding group based on structural analysis of its complex with carboxypeptidase A
Bioorg. Med. Chem. Lett.
19
5009-5011
2009
Bos taurus (P00730)
Fernandez, D.; Testero, S.; Vendrell, J.; Aviles, F.X.; Mobashery, S.
The X-ray structure of carboxypeptidase A inhibited by a thiirane mechanism-based inhibitor
Chem. Biol. Drug Des.
75
29-34
2010
Homo sapiens
Li, J.Y.; Moghaddam, S.H.; Chen, J.E.; Chen, M.; Zhong, B.X.
Shotgun proteomic analysis on the embryos of silkworm Bombyx mori at the end of organogenesis
Insect Biochem. Mol. Biol.
40
293-302
2010
Bombyx mori
Sui, Y.P.; Liu, X.B.; Chai, L.Q.; Wang, J.X.; Zhao, X.F.
Characterization and influences of classical insect hormones on the expression profiles of a molting carboxypeptidase A from the cotton bollworm (Helicoverpa armigera)
Insect Mol. Biol.
18
353-363
2009
Helicoverpa armigera
Dougherty, R.H.; Sidhu, S.S.; Raman, K.; Solon, M.; Solberg, O.D.; Caughey, G.H.; Woodruff, P.G.; Fahy, J.V.
Accumulation of intraepithelial mast cells with a unique protease phenotype in TH2-high asthma
J. Allergy Clin. Immunol.
125
1046-1053
2010
Homo sapiens
Xu, D.; Guo, H.
Quantum mechanical/molecular mechanical and density functional theory studies of a prototypical zinc peptidase (carboxypeptidase A) suggest a general acid-general base mechanism
J. Am. Chem. Soc.
131
9780-9788
2009
Bos taurus, Bos taurus (P00730)
Tanco, S.; Zhang, X.; Morano, C.; Aviles, F.X.; Lorenzo, J.; Fricker, L.D.
Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing
J. Biol. Chem.
285
18385-18396
2010
Homo sapiens
Van Damme, P.; Staes, A.; Bronsoms, S.; Helsens, K.; Colaert, N.; Timmerman, E.; Aviles, F.X.; Vandekerckhove, J.; Gevaert, K.
Complementary positional proteomics for screening substrates of endo- and exoproteases
Nat. Methods
7
512-515
2010
Homo sapiens
Kilshtain, A.V.; Warshel, A.
On the origin of the catalytic power of carboxypeptidase A and other metalloenzymes
Proteins
77
536-550
2009
Homo sapiens
Pejler, G.; Knight, S.D.; Henningsson, F.; Wernersson, S.
Novel insights into the biological function of mast cell carboxypeptidase A
Trends Immunol.
30
401-408
2009
Homo sapiens
Kumar, A.; Sharma, A.; Sharma, R.; Gakhar, S.K.
Identification, characterization and analysis of expression of gene encoding carboxypeptidase A in Anopheles culicifacies A (Diptera: culicidae)
Acta Trop.
139
123-130
2014
Anopheles culicifacies
Zhao, B.; Kokoza, V.A.; Saha, T.T.; Wang, S.; Roy, S.; Raikhel, A.S.
Regulation of the gut-specific carboxypeptidase: a study using the binary Gal4/UAS system in the mosquito Aedes aegypti
Insect Biochem. Mol. Biol.
54
1-10
2014
Aedes aegypti
Austin, B.; Waugh, D.
Isolation of Metarhizium anisopliae carboxypeptidase A with native disulfide bonds from the cytosol of Escherichia coli BL21(DE3)
Protein Expr. Purif.
82
116-124
2012
Metarhizium anisopliae
Testero, S.A.; Granados, C.; Fernandez, D.; Gallego, P.; Covaleda, G.; Reverter, D.; Vendrell, J.; Aviles, F.X.; Pallares, I.; Mobashery, S.
Discovery of mechanism-based inactivators for human pancreatic carboxypeptidase A from a focused synthetic library
ACS Med. Chem. Lett.
8
1122-1127
2017
Homo sapiens (P15085), Homo sapiens
VenkatRao, V.; Kumar, S.K.; Sridevi, P.; Muley, V.Y.; Chaitanya, R.K.
Cloning, characterization and transmission blocking potential of midgut carboxypeptidase A in Anopheles stephensi
Acta Trop.
168
21-28
2017
Anopheles stephensi (A0A0S2A471), Anopheles stephensi
Zhang, H.; Hao, C.; Wang, H.; Shang, H.; Li, Z.
Carboxypeptidase A4 promotes proliferation and stem cell characteristics of hepatocellular carcinoma
Int. J. Exp. Pathol.
100
133-138
2019
Homo sapiens
Kupski, L.; Queiroz, M.; Badiale-Furlong, E.
Application of carboxypeptidase A to a baking process to mitigate contamination of wheat flour by ochratoxin A
Process Biochem.
64
248-254
2018
Rhizopus arrhizus, Trichoderma reesei
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