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3.4.17.1: carboxypeptidase A

This is an abbreviated version!
For detailed information about carboxypeptidase A, go to the full flat file.

Word Map on EC 3.4.17.1

Reaction

release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro =

Synonyms

A-type metallocarboxypeptidase, AcCP, Anson's enzyme, ASPA, aspartoacyclase, carboxypeptidase, carboxypeptidase a, carboxypeptidase A-6, carboxypeptidase A-like activity, carboxypeptidase A1, carboxypeptidase A2, Carboxypeptidase A3, carboxypeptidase A4, carboxypeptidase vitellogenic-like, carboxypeptidase-A, carboxypolypeptidase, colon mast cell carboxypeptidase, CPA, CPA1, CPA3, CPA4, CPA6, CPAI, CPD, CPVL, EC 3.4.12.2, EC 3.4.2.1, hCPA, hCPA4, mast cell carboxypeptidase A, mast cell CPA, mast cell-CPA, mast-cell carboxypeptidase A, mast-cell CPA, MC-CP, MC-CPA, MCCPA, MCP-2, mCPA, MDCP-A1, MDCP-A2, MeCPA, MF-CPA, molting carboxypeptidase A, molting fluid carboxypeptidase A, More, Nna1/CCP1, ochratoxin A hydrolytic enzyme, PTD012, RMC-CP, vitellogenic-like carboxypeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.17 Metallocarboxypeptidases
                3.4.17.1 carboxypeptidase A

KI Value

KI Value on EC 3.4.17.1 - carboxypeptidase A

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0011
(+-)-2-benzylsuccinic acid
-
-
0.00001
(2E)-2-mercapto-3-phenylacrylic acid
-
pH 7.5, 25°C
0.0021
(2E)-2-mercapto-4-phenylbut-2-enoic acid
-
pH 7.5, 25°C
0.00135
(2E)-2-mercapto-5-phenylpent-2-enoic acid
-
pH 7.5, 25°C
5.4 - 5.7
(2R,3S)-2-benzyl-2-methyl-3,4-epoxybutanoic acid
0.3 - 1.1
(2R,3S)-2-benzyl-3,4-epoxybutanoic acid
2.79
(2R,4S)-2-benzyl-3-methanesulfinylpropanoic acid
-
pH 7.5
0.0000000048
(2S)-2-([hydroxy[(1R)-1-[[1-(1,4,7,10-tetraazacyclododecan-1-ylacetyl)-L-prolyl]amino]ethyl]phosphoryl]oxy)-3-phenylpropanoic acid
-
pH 7.5, 25°C
0.00000018
(2S)-2-([hydroxy[(1R)-1-[[N-(1,4,7,10-tetraazacyclododecan-1-ylacetyl)-b-alanyl]amino]ethyl]phosphoryl]oxy)-3-phenylpropanoic acid
-
pH 7.5, 25°C
0.0000000084
(2S)-2-([hydroxy[(1R)-1-[[N-(1,4,7,10-tetraazacyclododecan-1-ylacetyl)-L-alanyl]amino]ethyl]phosphoryl]oxy)-3-phenylpropanoic acid
-
pH 7.5, 25°C
0.000000059
(2S)-2-([hydroxy[(1R)-1-[[N-(1,4,7,10-tetraazacyclododecan-1-ylacetyl)-L-phenylalanyl]amino]ethyl]phosphoryl]oxy)-3-phenylpropanoic acid
-
pH 7.5, 25°C
0.000000082
(2S)-2-([hydroxy[(1R)-1-[[N-(1,4,7,10-tetraazacyclododecan-1-ylacetyl)glycyl]amino]ethyl]phosphoryl]oxy)-3-phenylpropanoic acid
-
pH 7.5, 25°C
0.000000077
(2S)-2-([hydroxy[(1S)-1-[[1-(1,4,7,10-tetraazacyclododecan-1-ylacetyl)-L-prolyl]amino]ethyl]phosphoryl]oxy)-3-phenylpropanoic acid
-
pH 7.5, 25°C
0.0000009
(2S)-2-([hydroxy[(1S)-1-[[N-(1,4,7,10-tetraazacyclododecan-1-ylacetyl)-b-alanyl]amino]ethyl]phosphoryl]oxy)-3-phenylpropanoic acid
-
pH 7.5, 25°C
0.00000009
(2S)-2-([hydroxy[(1S)-1-[[N-(1,4,7,10-tetraazacyclododecan-1-ylacetyl)-L-alanyl]amino]ethyl]phosphoryl]oxy)-3-phenylpropanoic acid
-
pH 7.5, 25°C
0.0000021
(2S)-2-([hydroxy[(1S)-1-[[N-(1,4,7,10-tetraazacyclododecan-1-ylacetyl)-L-phenylalanyl]amino]ethyl]phosphoryl]oxy)-3-phenylpropanoic acid
-
pH 7.5, 25°C
0.0000042
(2S)-2-([hydroxy[(1S)-1-[[N-(1,4,7,10-tetraazacyclododecan-1-ylacetyl)glycyl]amino]ethyl]phosphoryl]oxy)-3-phenylpropanoic acid
-
pH 7.5, 25°C
0.0000009
(2S)-2-[(hydroxy[(1R)-1-[(1,4,7,10-tetraazacyclododecan-1-ylacetyl)amino]ethyl]phosphoryl)oxy]-3-phenylpropanoic acid
-
pH 7.5, 25°C
1.1 - 2.2
(2S,3R)-2-benzyl-2-methyl-3,4-epoxybutanoic acid
0.19
(2S,3R)-2-benzyl-3,4-epoxybutanoic acid
-
pH 7.5, 25°C, substrate: hippuryl-L-Phe
3.86
(2S,4R)-2-benzyl-3-methanesulfinylpropanoic acid
-
pH 7.5
0.56
(2S,4S)-2-benzyl-3-methanesulfinylpropanoic acid
-
pH 7.5
1.46
(R)-2-benzyl-3-(methylthio)propanoic acid
-
pH 7.5
1.4
(R)-2-benzyl-3-(N-sulfamoyl)aminopropanoic acid
pH 7.5
0.00015
(R)-2-benzyl-3-nitropropanoic acid
-
-
0.00043
(R)-2-benzyl-5-nitro-4-oxopentanoic acid
in 0.05 M Tris/0.5 M NaCl buffer, pH 7.5
0.405
(R)-hippuryl-alpha-MePhe
-
pH 7.5
0.00036
(R)-N-(2-chloroethyl)-N-methylphenylalanine
-
pH 7.5
0.072
(R)-N-(N-hydroxysulfamoyl)phenylalanine
0.033
(R)-N-benzylcysteine
-
pH 7.5, 25°C
0.0079
(R)-N-cyclohexylcysteine
-
pH 7.5, 25°C
0.00056
(R)-N-formyl-N-hydroxyphenylalanine
-
pH 7.5
0.039
(R)-N-hydroxy-N-sulfamoyl-beta-phenylalanine
0.0029
(R)-N-isopropylcysteine
-
pH 7.5, 25°C
0.00061
(R)-N-phenethylcysteine
-
pH 7.5, 25°C
0.47
(R)-N-sulfamoylphenylalanine
0.00209
(R,S)-N-(hydroxyaminocarbonyl)-phenylalanine
-
pH 7.5
0.1
(RS)-2-benzyl-3-(methylthio)propanoic acid
-
pH 7.5
0.00079
(RS)-2-benzyl-3-nitropropanoic acid
-
-
0.00353
(RS)-2-benzyl-3-sulfamoylpropionic acid
-
pH 7.5
0.002
(RS)-2-isobutyl-3-nitropropanoic acid
-
-
0.00038
(RS)-2-mercaptomethyl-2-methyl-3-phenylpropanoic acid
-
pH 7.5
0.00011
(RS)-2-mercaptomethyl-2-methylbutanoic acid
-
pH 7.5
0.0001
(RS)-2-mercaptomethylbutyric acid
-
pH 7.5
0.00198
(RS)-3-phenyl-2-sulfamoyloxypropionic acid
-
pH 7.5
0.00209
(RS)-N-(hydroxyaminocarbonyl)-phenylalanine
-
pH 7.5
0.067
(RS)-N-formyl-N-hydroxyphenylalanine
-
pH 7.5
0.00142
(RS)-N-sulfamoylphenylalanine
-
pH 7.5
0.000000015 - 0.00000026
(S)-2-(Hydroxy-[(S)-1-[(S)-3-methyl-2-(2-1,4,7,10tetraaza-cyclododec-1-yl-acetylamino)-pentanoylamino]-ethyl]-phosphinoyloxy)-3-phenyl-propionic acid
0.74
(S)-2-benzyl-3-(methylthio)propanoic acid
-
pH 7.5
2.9
(S)-2-benzyl-3-(N-sulfamoyl)aminopropanoic acid
pH 7.5
0.068
(S)-2-benzyl-3-nitropropanoic acid
-
-
0.00016
(S)-2-benzyl-5-nitro-4-oxopentanoic acid
in 0.05 M Tris/0.5 M NaCl buffer, pH 7.5
0.0025
(S)-N-(2-chloroethyl)-N-methylphenylalanine
-
pH 7.5
0.035
(S)-N-(N-benzylsulfamoyl)phenylalanine
pH 7.5
0.0032
(S)-N-(N-hydroxysulfamoyl)phenylalanine
0.61
(S)-N-(N-isopropylsulfamoyl)phenylalanine
pH 7.5
0.18
(S)-N-(N-methylsulfamoiyl)phenylalanine
pH 7.5
0.18
(S)-N-(N-phenylethylsulfamoyl)phenylalanine
pH 7.5
0.00019
(S)-N-benzylcysteine
-
pH 7.5, 25°C
0.0029
(S)-N-cyclohexylcysteine
-
pH 7.5, 25°C
0.00495
(S)-N-formyl-N-hydroxyphenylalanine
-
pH 7.5
1.9
(S)-N-hydroxy-N-sulfamoyl-beta-phenylalanine
0.00056
(S)-N-isopropylcysteine
-
pH 7.5, 25°C
3.5
(S)-N-methyl-N-sulfamoylphenylalanine
pH 7.5
0.000055
(S)-N-phenethylcysteine
-
pH 7.5, 25°C
0.00065
(S)-N-sulfamoylphenylalanine
-
pH 7.5
0.00065
(S)-N-sulfamoylphenylalanine benzyl ester
pH 7.5
0.00529
2-(1-hydroxy-5-oxopyrrolidin-2-yl)-3-phenylpropanoic acid
-
25°C, limiting value for Ki-value at intermediate pH
0.000011
2-benzyl-3-mecaptopropionate
-
-
0.00015
2-benzyl-3-nitropropanoic acid
-
-
0.00259
2-benzyl-3-[(difluoroacetyl)(hydroxy)amino]propanoic acid
-
25°C, limiting value for Ki-value at intermediate pH
0.012
2-benzyl-3-[(fluoroacetyl)(hydroxy)amino]propanoic acid
-
25°C, limiting value for Ki-value at intermediate pH
0.00139
2-benzyl-3-[formyl(hydroxy)amino]propanoic acid
-
25°C, limiting value for Ki-value at intermediate pH
0.009
2-benzyl-3-[hydroxy(methoxyacetyl)amino]propanoic acid
-
25°C, limiting value for Ki-value at intermediate pH
0.0994
2-benzyl-3-[hydroxy(methoxycarbonyl)amino]propanoic acid
-
25°C, limiting value for Ki-value at intermediate pH
0.00942
2-benzyl-3-[hydroxy(trifluoroacetyl)amino]propanoic acid
-
25°C, limiting value for Ki-value at intermediate pH
0.207
2-benzyl-4-oxopentanoic acid
in 0.05 M Tris/0.5 M NaCl buffer, pH 7.5
0.0002
2-benzyl-5,5,5-trifluoro-4-oxopentanoic acid
in 0.05 M Tris/0.5 M NaCl buffer, pH 7.5
0.015
2-benzyl-5-bromo-4-oxopentanoic acid
in 0.05 M Tris/0.5 M NaCl buffer, pH 7.5
0.0242
3-hydroxyaminocarbonyl-2-benzylpropanoic acid
-
pH 7.5, 25°C
0.062 - 6.1
3-Phenylpropionic acid
0.00806
3-[acetyl(hydroxy)amino]-2-benzylpropanoic acid
-
25°C, limiting value for Ki-value at intermediate pH
0.118
4-phenylbutyric acid
-
-
0.039
aminobenzylsuccinic acid
-
-
0.0055
anilino(mercapto)acetic acid
-
-
0.0000239
Ascaris carboxypeptidase inhibitor
-
-
-
0.00000071
CBZ-Ala-Gly-PSI[P(O2)O]-Phe
-
crystallographic study of structure
5
cinnamate
-
-
0.0023
D-Cys
20
D-His
-
-
0.00154
D-N-(hydroxyaminocarbonyl)phenylalanine
-
pH 7.5, 25°C
0.0015
D-N-hydroxyaminocarbonyl phenylalanine
-
1.2
D-penicillamine
-
zinc carboxypeptidase A
0.074 - 2
D-Phe
0.014
D-Trp
-
-
0.1
Gly-L-Tyr
-
-
0.078
indole acetic acid
-
-
0.35
L-Cys
0.01898
L-N-(aminocarbonyl)phenylalanine
-
pH 7.5, 25°C
0.00456
L-N-(hydroxyaminocarbonyl)phenylalanine
-
pH 7.5, 25°C
0.0046
L-N-hydroxyaminocarbonyl phenylalanine
-
1.7
L-Penicillamine
-
zinc carboxypeptidase A
0.0021
L-Phe-phosphoramidate-phenylester
-
-
0.058
L-Phenyllactate
-
-
0.000003
latexin
-
0.0000073
leech carboxypeptidase inhibitor
-
-
-
0.0024
mercapto(methylamino)acetic acid
-
pH 7.5, 25°C
0.00022
mercaptoacetyl-D-Phe
-
-
0.000000026
N-(1,4,7,10-tetraazacyclododecan-1-ylacetyl)glycyl-N-[(1R)-1-[[(1S)-1-carboxy-2-phenylethoxy](hydroxy)phosphoryl]ethyl]glycinamide
-
pH 7.5, 25°C
0.0000032
N-(1,4,7,10-tetraazacyclododecan-1-ylacetyl)glycyl-N-[(1S)-1-[[(1S)-1-carboxy-2-phenylethoxy](hydroxy)phosphoryl]ethyl]glycinamide
-
pH 7.5, 25°C
0.0021
N-phenylphosphoryl-L-phenylalanine
-
-
2.5
p-nitrophenylacetic acid
-
-
0.001
Phe phosphonate
-
-
0.39
phenylacetic acid
-
-
0.000001
polypeptide inhibitor
-
molecular weight 10000
-
0.0000013 - 0.000107
potato carboxypeptidase inhibitor
-
0.0000069
potato carboxypeptidase inhibitor mutant DELTA39
-
-
-
0.0000185
potato carboxypeptidase inhibitor mutant F23A
-
pH 7.5
-
0.00044
potato carboxypeptidase inhibitor mutant F23A/W28A
-
pH 7.5
-
0.0000023
potato carboxypeptidase inhibitor mutant H15A
-
pH 7.5
-
0.0000015
potato carboxypeptidase inhibitor mutant N29A
-
pH 7.5
-
0.0000019
potato carboxypeptidase inhibitor mutant N29A/S30A
-
pH 7.5
-
0.0000035
potato carboxypeptidase inhibitor mutant N29G
-
pH 7.5
-
0.000125
potato carboxypeptidase inhibitor mutant P36G
-
-
-
0.0000014
potato carboxypeptidase inhibitor mutant S30A
-
pH 7.5
-
0.0000079
potato carboxypeptidase inhibitor mutant W22A
-
pH 7.5
-
0.0000132
potato carboxypeptidase inhibitor mutant W28A
-
pH 7.5
-
0.0000056
potato carboxypeptidase inhibitor mutant Y37G
-
-
-
0.000347
potato carboxypeptidase inhibitor mutant Y37G/DELTA39
-
-
-
0.00235
rac-2-(mercaptomethyl)-3-cyclohexylpropanoic acid
-
pH 7.5, 25°C
0.00016
rac-2-(mercaptomethyl)-4-methylpentanoic acid
-
pH 7.5, 25°C
0.000011
rac-2-benzyl-3-mercaptopropanoic acid
-
pH 7.5, pH 25°C
0.0016
rac-2-benzyl-5-chloropentanoic acid
-
pH 7.5
0.00081
rac-N-(1-naphthylmethyl)cysteine
-
pH 7.5, 25°C
0.0585
rac-N-(aminocarbonyl)phenylalanine
-
pH 7.5, 25°C
0.0094
rac-N-(cyclohexylmethyl)cysteine
-
pH 7.5, 25°C
0.00209
rac-N-(hydroxyaminocarbonyl)phenylalanine
-
pH 7.5, 25°C
0.00085
rac-N-(p-methoxy)benzylcysteine
-
pH 7.5, 25°C
0.012
rac-N-benzyl-N-methylcysteine
-
pH 7.5, 25°C
0.00027
rac-N-benzylcysteine
-
pH 7.5, 25°C
0.0096
rac-N-cyclohexylcysteine
-
pH 7.5, 25°C
0.0014
rac-N-ethylcysteine
-
pH 7.5, 25°C
0.0075
rac-N-isobutylcysteine
-
pH 7.5, 25°C
0.0011
rac-N-isopropylcysteine
-
pH 7.5, 25°C
0.000065
rac-N-phenethylcysteine
-
pH 7.5, 25°C
0.0013
rac-N-phenylpropylcysteine
-
pH 7.5, 25°C
0.0056
rac-N-propylcysteine
-
pH 7.5, 25°C
0.0013
rac2-(mercaptomethyl)-6-phenylhexanoic acid
-
pH 7.5, 25°C
5.9
threo-2-benzyl-2-methyl-3,4-epoxybutanoic acid
-
pH 7.5, 25°C, substrate: hippuryl-L-Phe
0.0000008
tick carboxypeptidase inhibitor
-
-
-
0.0000016
wild-type potato carboxypeptidase inhibitor
-
pH 7.5
-
additional information
additional information
-