3.4.17.1: carboxypeptidase A

This is an abbreviated version!
For detailed information about carboxypeptidase A, go to the full flat file.

Reaction

release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro =

Synonyms

A-type metallocarboxypeptidase, AcCP, Anson's enzyme, ASPA, aspartoacyclase, carboxypeptidase, carboxypeptidase a, carboxypeptidase A-6, carboxypeptidase A-like activity, carboxypeptidase A1, carboxypeptidase A2, Carboxypeptidase A3, carboxypeptidase A4, carboxypeptidase vitellogenic-like, carboxypeptidase-A, carboxypolypeptidase, colon mast cell carboxypeptidase, CPA, CPA1, CPA3, CPA4, CPA6, CPAI, CPD, CPVL, EC 3.4.12.2, EC 3.4.2.1, hCPA, hCPA4, mast cell carboxypeptidase A, mast cell CPA, mast cell-CPA, mast-cell carboxypeptidase A, mast-cell CPA, MC-CP, MC-CPA, MCCPA, MCP-2, mCPA, MDCP-A1, MDCP-A2, MeCPA, MF-CPA, molting carboxypeptidase A, molting fluid carboxypeptidase A, More, Nna1/CCP1, ochratoxin A hydrolytic enzyme, PTD012, RMC-CP, vitellogenic-like carboxypeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.17 Metallocarboxypeptidases

                3.4.17.1 carboxypeptidase A

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Results	in table
20	Activating Compound
121	AA Sequence
32	Application
2	CAS Registry Number
30	Cloned(Commentary)
31	Crystallization (Commentary)
6802	Disease/ Diagnostics
8	Expression
4	General Information
9	General Stability
8	IC50 Value
325	Inhibitors
12	kcat/KM [mM/s]
177	Ki Value [mM]
105	KM Value [mM]
28	Localization
87	Metals/Ions
58	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
172	Organism
62	PDB ID
53	pH Optimum
13	pH Range
9	pH Stability
15	pI Value
9	Posttranslational Modification
40	Protein Variants
37	Purification (Commentary)
27	Reaction
27	Reaction Type
168	Reference
2	Renatured (Commentary)
168	Source Tissue
36	Specific Activity [micromol/min/mg]
9	Storage Stability
232	Substrates and Products (Substrate)
25	Subunits
156	Synonyms
35	Temperature Optimum [°C]
1	Temperature Range [°C]
12	Temperature Stability [°C]
90	Turnover Number [1/s]

Expression

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Expression on EC 3.4.17.1 - carboxypeptidase A

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

CPA4 is upregulated by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells

Homo sapiens

-

705857

expression increases several fold after blood feeding

Anopheles culicifacies

-

731097

expression is up-regulated by a blood meal in the midgut of female mosquitoes

Aedes aegypti

-

731919

gene expression is significantly elevated in Plasmodium berghei-infected mosquitoes compared to uninfected blood-fed controls

Anopheles stephensi

A0A0S2A471

752414

MC-CPA gene expression is about 2fold upregulated by bacterial lipopolysaccharide

Homo sapiens

-

706874

TH2-high asthma cells are characterized by expression of CPA3

Homo sapiens

-

704153

the 5'-upstream region of the carboxypeptidase gene is used to establish the Aedes aegypti CP-Gal4 driver line. The CPGal4 driver activates a UAS-EGFP responder in midguts of CPGal4-UAS-EGFP females in a blood meal dependent manner. Transgene expression is regulated by insulin and amino acid/TOR pathways

Aedes aegypti

-

731919

the expression of CPA can be up-regulated by 20-hydroxyecdysone. In the integument, the transcription level of the gene reaches its peak at the 5th instar molting stage and the 6th instar prepupal stage, respectively

Helicoverpa armigera

-

704029