3.3.2.11: cholesterol-5,6-oxide hydrolase

This is an abbreviated version!
For detailed information about cholesterol-5,6-oxide hydrolase, go to the full flat file.

Reaction

Synonyms

anti-estrogen binding site, CEHase, ChEH, cholEH, cholesterol 5alpha,6alpha-oxide hydrolase, cholesterol epoxide hydrolase, cholesterol oxide hydrolase, cholesterol-5,6-epoxide hydrolase, cholesterol-epoxide hydrolase, EH_CH

ECTree

     3 Hydrolases

         3.3 Acting on ether bonds

             3.3.2 Ether hydrolases

                3.3.2.11 cholesterol-5,6-oxide hydrolase

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Results	in table
6	Activating Compound
5	AA Sequence
2	Application
1	CAS Registry Number
12	Disease/ Diagnostics
1	Expression
9	General Information
24	IC50 Value
126	Inhibitors
62	Ki Value [mM]
10	KM Value [mM]
18	Localization
35	Natural Substrates/ Products (Substrates)
21	Organism
5	Oxidation Stability
11	pH Optimum
1	pH Range
12	Purification (Commentary)
4	Reaction
21	Reference
38	Source Tissue
21	Specific Activity [micromol/min/mg]
1	Storage Stability
57	Substrates and Products (Substrate)
27	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]

Substrates Products

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of the Enzyme Summary Page.

Substrates Products on EC 3.3.2.11 - cholesterol-5,6-oxide hydrolase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

5,6-epoxy-5alpha-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Rattus norvegicus

-

-

661023

-

-

?

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

5alpha-cholestane-3beta,5alpha,6beta-triol

2 entries

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

16 entries

5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O

5alpha-cholestane-3beta,5alpha,6beta-triol

3 entries

5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O

5alpha-cholestane-3beta,5alpha,6beta-triol

2 entries

5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

6 entries

additional information

?

-

12 entries

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

5alpha-cholestane-3beta,5alpha,6beta-triol

Homo sapiens

-

-

706552, 731280, 731693, 752861, 753646

-

-

?

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

5alpha-cholestane-3beta,5alpha,6beta-triol

Rattus norvegicus

-

-

706552, 731385

-

-

?

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Homo sapiens

-

-

660783, 743697

-

-

?

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Homo sapiens

-

the enzyme is equally active with both stereoisomers

660783

-

-

?

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Mesocricetus auratus

-

-

660783

-

-

?

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Mesocricetus auratus

-

the enzyme is equally active with both stereoisomers

660783

-

-

?

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Mus musculus

-

-

660783, 660845

-

-

?

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Mus musculus

-

the substrate is a product of lipid peroxidation in the liver

660845

-

-

?

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Mus musculus

-

the enzyme is equally active with both stereoisomers

660783

-

-

?

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Oryctolagus cuniculus

-

-

660783

-

-

?

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Oryctolagus cuniculus

-

the enzyme is highly substrate-specific

661435

-

-

?

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Oryctolagus cuniculus

-

the enzyme is equally active with both stereoisomers

660783

-

-

?

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Rattus norvegicus

-

-

660783, 661275, 662082, 662084

-

-

?

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Rattus norvegicus

-

regulation, the enzyme is highly substrate specific

660782

-

-

?

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Rattus norvegicus

-

the enzyme is highly substrate-specific

661435

-

-

?

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Rattus norvegicus

-

the enzyme is highly substrate-specific

660782

i.e. 5,6-glycol

-

?

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Rattus norvegicus

-

the enzyme is equally active with both stereoisomers

660783, 662084

-

-

?

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Rattus norvegicus

-

the enzyme is highly substrate specific

661275

-

-

?

5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O

5alpha-cholestane-3beta,5alpha,6beta-triol

Homo sapiens

-

-

731280, 753646

-

-

?

5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O

5alpha-cholestane-3beta,5alpha,6beta-triol

Homo sapiens

-

better substrate

731693

-

-

?

5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O

5alpha-cholestane-3beta,5alpha,6beta-triol

Rattus norvegicus

-

best substrate

731385

-

-

?

5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O

5alpha-cholestane-3beta,5alpha,6beta-triol

Homo sapiens

-

-

706552

-

-

?

5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O

5alpha-cholestane-3beta,5alpha,6beta-triol

Rattus norvegicus

-

-

706552

-

-

?

5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Homo sapiens

-

the enzyme is equally active with both stereoisomers

660783

-

-

?

5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Mesocricetus auratus

-

the enzyme is equally active with both stereoisomers

660783

-

-

?

5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Mus musculus

-

the enzyme is equally active with both stereoisomers

660783

-

-

?

5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Oryctolagus cuniculus

-

the enzyme is equally active with both stereoisomers

660783

-

-

?

5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Rattus norvegicus

-

-

660783, 662082, 662084

-

-

?

5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O

cholestane-3beta,5alpha,6beta-triol

Rattus norvegicus

-

the enzyme is equally active with both stereoisomers

660783, 662084

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.9, which shows a wider substrate specificity

660783

-

-

?

additional information

?

-

Mesocricetus auratus

-

the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.9, which shows a wider substrate specificity

660783

-

-

?

additional information

?

-

Mus musculus

-

the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.9, which shows a wider substrate specificity

660783

-

-

?

additional information

?

-

Mus musculus

-

the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.9, which shows a wider xenobiotic substrate specificity

660845

-

-

?

additional information

?

-

Oryctolagus cuniculus

-

the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.9, which shows a wider substrate specificity

660783

-

-

?

additional information

?

-

Oryctolagus cuniculus

-

the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.9, which shows a wider substrate specificity

661435

-

-

?

additional information

?

-

Rattus norvegicus

-

the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.9

662082

-

-

?

additional information

?

-

Rattus norvegicus

-

the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.9

662084

-

-

?

additional information

?

-

Rattus norvegicus

-

the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.9, which shows a wider substrate specificity

660783

-

-

?

additional information

?

-

Rattus norvegicus

-

the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.9, which shows a wider substrate specificity

661435

-

-

?

additional information

?

-

Rattus norvegicus

-

the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.9, which shows a wider xenobiotic substrate specificity

660782

-

-

?

additional information

?

-

Rattus norvegicus

-

no activity with xenobiotic alkene oxides and arene oxides, e.g. octene 1,2-oxide or benz[a]anthracene 5,6-oxide

660782

-

-

?