3.3.2.11: cholesterol-5,6-oxide hydrolase

This is an abbreviated version!
For detailed information about cholesterol-5,6-oxide hydrolase, go to the full flat file.

Word Map on EC 3.3.2.11

3.3.2.11

anti-estrogenic

oxysterols

diphenylmethane

hetero-oligomeric

hormonotherapy

medicine

drug development

Reaction

5,6alpha-epoxy-5alpha-cholestan-3beta-ol

5alpha-cholestane-3beta,5alpha,6beta-triol

Synonyms

anti-estrogen binding site, CEHase, ChEH, cholEH, cholesterol 5alpha,6alpha-oxide hydrolase, cholesterol epoxide hydrolase, cholesterol oxide hydrolase, cholesterol-5,6-epoxide hydrolase, cholesterol-epoxide hydrolase, EH_CH

ECTree

3 Hydrolases

3.3 Acting on ether bonds

3.3.2 Ether hydrolases

3.3.2.11 cholesterol-5,6-oxide hydrolase

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6	Activating Compound
5	AA Sequence
2	Application
1	CAS Registry Number
12	Disease/ Diagnostics
1	Expression
9	General Information
24	IC50 Value
126	Inhibitors
62	Ki Value [mM]
10	KM Value [mM]
18	Localization
35	Natural Substrates/ Products (Substrates)
21	Organism
5	Oxidation Stability
11	pH Optimum
1	pH Range
12	Purification (Commentary)
4	Reaction
21	Reference
38	Source Tissue
21	Specific Activity [micromol/min/mg]
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57	Substrates and Products (Substrate)
27	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]

Purification

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Purification on EC 3.3.2.11 - cholesterol-5,6-oxide hydrolase

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from microsomes, separation from EC 3.3.2.9 by immunoprecipitation

2 entries

liver microsome preparation

5 entries

partially by microsome preparation

Rattus norvegicus

662082, 662084

partially by subcellular fractionation

Rattus norvegicus

661275

partially from liver by micosome preparation and immunoprecipitation, separation from the xenobiotic epoxide hydrolase, EC 3.3.2.9

Rattus norvegicus

660782

partially from liver by micosome preparation, two steps of gel filtration, separation from the xenobiotic epoxide hydrolase, EC 3.3.2.9

Mus musculus

660845