3.3.2.11: cholesterol-5,6-oxide hydrolase
This is an abbreviated version!
For detailed information about cholesterol-5,6-oxide hydrolase, go to the full flat file.
Word Map on EC 3.3.2.11
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3.3.2.11
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anti-estrogenic
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oxysterols
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diphenylmethane
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hetero-oligomeric
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hormonotherapy
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medicine
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drug development
- 3.3.2.11
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anti-estrogenic
- oxysterols
- diphenylmethane
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hetero-oligomeric
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hormonotherapy
- medicine
- drug development
Reaction
Synonyms
anti-estrogen binding site, CEHase, ChEH, cholEH, cholesterol 5alpha,6alpha-oxide hydrolase, cholesterol epoxide hydrolase, cholesterol oxide hydrolase, cholesterol-5,6-epoxide hydrolase, cholesterol-epoxide hydrolase, EH_CH
ECTree
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KI Value
KI Value on EC 3.3.2.11 - cholesterol-5,6-oxide hydrolase
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0.000155
(11beta,17beta)-11-{4-[2-(Dimethylamino)ethoxy]phenyl}estra-1,3,5(10)-triene-3,17-diol
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pH 7.4, 37°C
0.000089
(4-(6-(allyl (methyl)amino)hexyloxy)phenyl)(4-bromophenyl)methanone
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pH 7.4, 37°C
0.0091
(E)-N,3,6,6-tetra methyl-N-(naphthalene-1-ylmethyl)hept-2-en-4-yn-1-amine
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pH 7.4, 37°C
0.000006
(E)-N-(4-(3-chloro-4-cyclohexylphenyl)but-3-enyl)-N-ethylcyclohexanamine
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pH 7.4, 37°C
0.000035
1-(2-(4-(2-phenylpropan-2-yl) phenoxy)ethyl)pyrrolidine
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pH 7.4, 37°C
0.000018
1-[2-[4-[(Z)-1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]pyrrolidine
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pH 7.4, 37°C
0.000039
2-(4-chlorophenyl)-1-(4-(2-(diethylamino)ethoxy)phenyl)-1-p-tolyl ethanol
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pH 7.4, 37°C
0.000009
2-[4-[(Z)-2-chloro-1,2-di (phenyl)ethenyl]phenoxy]-N,N-diethylethanamine
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pH 7.4, 37°C
0.000057
4-(2-(4-(2-phenylpropan-2-yl)phenoxy)ethyl)morpholine
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pH 7.4, 37°C
0.018
4-(4-(4-chloro phenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one
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pH 7.4, 37°C
0.000145
4-hydroxy-tamoxifen
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pH and temperature not specified in the publication
0.000145
4-[(Z)-1-[4-(2-dimethylaminoethyloxy)phenyl]-2-phenyl but-1-enyl]phenol
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pH 7.4, 37°C
0.0044
5,6alpha-epoxy-5alpha-cholestan-3beta-ol
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pH 7.4, 37°C, versus 5,6beta-epoxy-5alpha-cholestan-3beta-ol
0.000085
5,6alpha-imino-5alpha-cholestan-3beta-ol
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pH 7.4, 37°C, versus 5,6alpha-epoxy-5alpha-cholestan-3beta-ol
0.0037
5,6beta-epoxy-5beta-cholestan-3beta-ol
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pH 7.4, 37°C, versus 5,6alpha-epoxy-5alpha-cholestan-3beta-ol
0.126
9,10-iminophenanthrene
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pH 7.4, 37°C, versus 5,6alpha-epoxy-5alpha-cholestan-3beta-ol
0.0366
Iminosqualene
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pH 7.4, 37°C, versus 5,6alpha-epoxy-5alpha-cholestan-3beta-ol
0.000099
N-(3,4-dichlorophenethyl)-N-methyl-2-(pyrrolidin-1-yl)ethanemine
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pH 7.4, 37°C
0.000027
N-pyrrolidino-2-[4-(benzyl)-phenoxy]-ethanamine
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pH and temperature not specified in the publication
0.000203
phenyl{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}methanone
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pH 7.4, 37°C
0.000036
[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
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pH 7.4, 37°C
additional information
additional information
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inhibition kinetics at pH 8.0, 37°C, 6.5% v/v acetonitrile
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0.036
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pH and temperature not specified in the publication
0.0097
cholestane-3beta,5alpha,6beta-triol
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pH and temperature not specified in the publication
0.012
docosahexaenoic acid
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pH and temperature not specified in the publication
0.000135
trifluoroperazine
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pH and temperature not specified in the publication