Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.3.2.11: cholesterol-5,6-oxide hydrolase

This is an abbreviated version!
For detailed information about cholesterol-5,6-oxide hydrolase, go to the full flat file.

Word Map on EC 3.3.2.11

Reaction

5,6alpha-epoxy-5alpha-cholestan-3beta-ol
+
H2O
=
5alpha-cholestane-3beta,5alpha,6beta-triol

Synonyms

anti-estrogen binding site, CEHase, ChEH, cholEH, cholesterol 5alpha,6alpha-oxide hydrolase, cholesterol epoxide hydrolase, cholesterol oxide hydrolase, cholesterol-5,6-epoxide hydrolase, cholesterol-epoxide hydrolase, EH_CH

ECTree

     3 Hydrolases
         3.3 Acting on ether bonds
             3.3.2 Ether hydrolases
                3.3.2.11 cholesterol-5,6-oxide hydrolase

KI Value

KI Value on EC 3.3.2.11 - cholesterol-5,6-oxide hydrolase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000155
(11beta,17beta)-11-{4-[2-(Dimethylamino)ethoxy]phenyl}estra-1,3,5(10)-triene-3,17-diol
-
pH 7.4, 37°C
0.000241
(4-(2-morpholinoethoxy)phenyl)(phenyl)methanone
-
pH 7.4, 37°C
0.000089
(4-(6-(allyl (methyl)amino)hexyloxy)phenyl)(4-bromophenyl)methanone
-
pH 7.4, 37°C
0.0091
(E)-N,3,6,6-tetra methyl-N-(naphthalene-1-ylmethyl)hept-2-en-4-yn-1-amine
-
pH 7.4, 37°C
0.000006
(E)-N-(4-(3-chloro-4-cyclohexylphenyl)but-3-enyl)-N-ethylcyclohexanamine
-
pH 7.4, 37°C
0.000035
1-(2-(4-(2-phenylpropan-2-yl) phenoxy)ethyl)pyrrolidine
-
pH 7.4, 37°C
0.000027
1-(2-(4-benzylphenoxy)ethyl)-pyrrolidine
-
pH 7.4, 37°C
0.000902
1-(4-(2-morpholino ethoxy)phenyl)-2-phenylethanone
-
pH 7.4, 37°C
0.000018
1-[2-[4-[(Z)-1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]pyrrolidine
-
pH 7.4, 37°C
0.000062
2-(4-benzylphenoxy)-N,N-diethylethanamine
-
pH 7.4, 37°C
0.000039
2-(4-chlorophenyl)-1-(4-(2-(diethylamino)ethoxy)phenyl)-1-p-tolyl ethanol
-
pH 7.4, 37°C
0.0019
2-(diethylamino)ethyl 2,2-diphenylpentanoate
-
pH 7.4, 37°C
0.000009
2-[4-[(Z)-2-chloro-1,2-di (phenyl)ethenyl]phenoxy]-N,N-diethylethanamine
-
pH 7.4, 37°C
0.00009
3-beta-(2-(diethyl amino)ethoxy)androst-5-en-17-one
-
pH 7.4, 37°C
0.000057
4-(2-(4-(2-phenylpropan-2-yl)phenoxy)ethyl)morpholine
-
pH 7.4, 37°C
0.000027
4-(2-(4-benzylphenoxy)ethyl)morpholine
-
pH 7.4, 37°C
0.018
4-(4-(4-chloro phenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one
-
pH 7.4, 37°C
0.000145
4-hydroxy-tamoxifen
-
pH and temperature not specified in the publication
0.000145
4-[(Z)-1-[4-(2-dimethylaminoethyloxy)phenyl]-2-phenyl but-1-enyl]phenol
-
pH 7.4, 37°C
0.0044
5,6alpha-epoxy-5alpha-cholestan-3beta-ol
-
pH 7.4, 37°C, versus 5,6beta-epoxy-5alpha-cholestan-3beta-ol
0.000085
5,6alpha-imino-5alpha-cholestan-3beta-ol
-
pH 7.4, 37°C, versus 5,6alpha-epoxy-5alpha-cholestan-3beta-ol
0.0037
5,6beta-epoxy-5beta-cholestan-3beta-ol
-
pH 7.4, 37°C, versus 5,6alpha-epoxy-5alpha-cholestan-3beta-ol
0.0085
6-oxo-5-alpha-hydroxycholestanol
-
pH 7.4, 37°C
0.0023
6-oxocholestanol
-
pH 7.4, 37°C
0.0042
7-ketocholesterol
-
pH and temperature not specified in the publication
0.000864
7-oxocholestanol
-
pH 7.4, 37°C
0.0042
7-oxocholesterol
-
pH 7.4, 37°C
0.0061
7alpha-hydroxycholesterol
-
pH 7.4, 37°C
0.0069
7beta-hydroxycholesterol
-
pH 7.4, 37°C
0.126
9,10-iminophenanthrene
-
pH 7.4, 37°C, versus 5,6alpha-epoxy-5alpha-cholestan-3beta-ol
0.0035
AC-915
-
pH 7.4, 37°C
0.036 - 0.0363
alpha-linolenic acid
0.000733
amiodarone
0.024
arachidonic acid
0.0097
cholestane-3beta,5alpha,6beta-triol
0.012
docosahexaenoic acid
0.018
haloperidol
-
pH and temperature not specified in the publication
0.002
ibogaine
-
pH 7.4, 37°C
0.0366
Iminosqualene
-
pH 7.4, 37°C, versus 5,6alpha-epoxy-5alpha-cholestan-3beta-ol
0.000099
N-(3,4-dichlorophenethyl)-N-methyl-2-(pyrrolidin-1-yl)ethanemine
-
pH 7.4, 37°C
0.000027
N-pyrrolidino-2-[4-(benzyl)-phenoxy]-ethanamine
-
pH and temperature not specified in the publication
0.054
oleic acid
0.000203
phenyl{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}methanone
-
pH 7.4, 37°C
0.000036
raloxifene
-
pH and temperature not specified in the publication
0.0023
rimcazole
-
pH 7.4, 37°C
0.000006
SR31747A
-
pH and temperature not specified in the publication
0.000034
tamoxifen
0.0091
terbinafine
-
pH and temperature not specified in the publication
0.000062
tesmilifene
-
pH and temperature not specified in the publication
0.000649
trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane
-
pH 7.4, 37°C
0.000135
trifluoroperazine
0.00009
U-18666A
-
pH and temperature not specified in the publication
0.000036
[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
-
pH 7.4, 37°C
additional information
additional information
-
inhibition kinetics at pH 8.0, 37°C, 6.5% v/v acetonitrile
-