3.3.2.11: cholesterol-5,6-oxide hydrolase

This is an abbreviated version!
For detailed information about cholesterol-5,6-oxide hydrolase, go to the full flat file.

Word Map on EC 3.3.2.11

3.3.2.11

anti-estrogenic

oxysterols

diphenylmethane

hetero-oligomeric

hormonotherapy

medicine

drug development

Reaction

5,6alpha-epoxy-5alpha-cholestan-3beta-ol

5alpha-cholestane-3beta,5alpha,6beta-triol

Synonyms

anti-estrogen binding site, CEHase, ChEH, cholEH, cholesterol 5alpha,6alpha-oxide hydrolase, cholesterol epoxide hydrolase, cholesterol oxide hydrolase, cholesterol-5,6-epoxide hydrolase, cholesterol-epoxide hydrolase, EH_CH

ECTree

3 Hydrolases

3.3 Acting on ether bonds

3.3.2 Ether hydrolases

3.3.2.11 cholesterol-5,6-oxide hydrolase

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Results	in table
6	Activating Compound
5	AA Sequence
2	Application
1	CAS Registry Number
12	Disease/ Diagnostics
1	Expression
9	General Information
24	IC50 Value
126	Inhibitors
62	Ki Value [mM]
10	KM Value [mM]
18	Localization
35	Natural Substrates/ Products (Substrates)
21	Organism
5	Oxidation Stability
11	pH Optimum
1	pH Range
12	Purification (Commentary)
4	Reaction
21	Reference
38	Source Tissue
21	Specific Activity [micromol/min/mg]
1	Storage Stability
57	Substrates and Products (Substrate)
27	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]

IC50 Value

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IC50 Value on EC 3.3.2.11 - cholesterol-5,6-oxide hydrolase

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0.000765

1-(2-(4-benzylphenoxy)ethyl)pyrrolidin hydrochloride

Homo sapiens

pH and temperature not specified in the publication

731280

0.000231 - 0.00025

1-[2-[4-(phenylmethyl)phenoxy]ethyl]-pyrrolidine

2 entries

0.000065 - 0.000095

4-hydroxytamoxifen

2 entries

0.11

cholestane-3beta,5alpha,6alpha-triol

Rattus norvegicus

IC50 is 0.110 mM

660783

0.03

cholestane-3beta,5alpha,6beta-triol

Rattus norvegicus

IC50 is 0.03 mM

660783

0.085

cholestane-3beta,5beta,6alpha-triol

Rattus norvegicus

IC50 is 0.085 mM

660783

0.118

cholestane-3beta,5beta,6beta-triol

Rattus norvegicus

IC50 is 0.118 mM

660783

0.125

cholesterol

Rattus norvegicus

IC50 is above 0.125 mM

660783

0.00006 - 0.000064

clomiphene

2 entries

0.000313 - 0.00035

dendrogenin A

2 entries

0.16

oxidosqualene

Rattus norvegicus

IC50 is above 0.16 mM

660783

0.000069 - 0.0001

raloxifene

2 entries

0.003 - 0.0035

rimcazole

2 entries

0.0000599 - 0.00011

tamoxifen

3 entries

0.000172 - 0.00021

tesmilifene

2 entries