3.3.2.11: cholesterol-5,6-oxide hydrolase
This is an abbreviated version!
For detailed information about cholesterol-5,6-oxide hydrolase, go to the full flat file.
Word Map on EC 3.3.2.11
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3.3.2.11
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anti-estrogenic
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oxysterols
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diphenylmethane
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hetero-oligomeric
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hormonotherapy
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medicine
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drug development
- 3.3.2.11
-
anti-estrogenic
- oxysterols
- diphenylmethane
-
hetero-oligomeric
-
hormonotherapy
- medicine
- drug development
Reaction
Synonyms
anti-estrogen binding site, CEHase, ChEH, cholEH, cholesterol 5alpha,6alpha-oxide hydrolase, cholesterol epoxide hydrolase, cholesterol oxide hydrolase, cholesterol-5,6-epoxide hydrolase, cholesterol-epoxide hydrolase, EH_CH
ECTree
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Systematic Name
Systematic Name on EC 3.3.2.11 - cholesterol-5,6-oxide hydrolase
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5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase
The enzyme appears to work equally well with either epoxide as substrate [3]. The product is a competitive inhibitor of the reaction. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol 5,6-oxide hydrolase) [3].