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3.3.2.11: cholesterol-5,6-oxide hydrolase

This is an abbreviated version!
For detailed information about cholesterol-5,6-oxide hydrolase, go to the full flat file.

Word Map on EC 3.3.2.11

Reaction

5,6alpha-epoxy-5alpha-cholestan-3beta-ol
+
H2O
=
5alpha-cholestane-3beta,5alpha,6beta-triol

Synonyms

anti-estrogen binding site, CEHase, ChEH, cholEH, cholesterol 5alpha,6alpha-oxide hydrolase, cholesterol epoxide hydrolase, cholesterol oxide hydrolase, cholesterol-5,6-epoxide hydrolase, cholesterol-epoxide hydrolase, EH_CH

ECTree

     3 Hydrolases
         3.3 Acting on ether bonds
             3.3.2 Ether hydrolases
                3.3.2.11 cholesterol-5,6-oxide hydrolase

Application

Application on EC 3.3.2.11 - cholesterol-5,6-oxide hydrolase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug development
-
the enzyme is a target for inhibition of the 6-oxo-cholestan-3beta,5alpha-diol (OCDO) biosynthesis in cancer therapy
medicine
-
in breast cancer tissue, cholesterol epoxide hydrolase ChEH metabolizes cholesterol-5,6-epoxide into cholestane-3beta,5alpha,6beta-triol, which is transformed into the oncometabolite 6-oxo-cholestan-3beta,5alpha-diol by 11beta-hydroxysteroid-dehydrogenase 11betaHSD2. ChEH inhibition and 11betaHSD2 silencing inhibit 6-oxo-cholestan-3beta,5alpha-diol production and tumor growth. Patient breast cancer samples show significantly increased 6-oxocholestan-3beta,5alpha-diol levels and greater ChEH and 11betaHSD2 protein expression compared with normal tissues, and 11betaHSD2 and ChEH overexpression correlate with a higher risk of patient death