3.3.2.11: cholesterol-5,6-oxide hydrolase

This is an abbreviated version!
For detailed information about cholesterol-5,6-oxide hydrolase, go to the full flat file.

Reaction

Synonyms

anti-estrogen binding site, CEHase, ChEH, cholEH, cholesterol 5alpha,6alpha-oxide hydrolase, cholesterol epoxide hydrolase, cholesterol oxide hydrolase, cholesterol-5,6-epoxide hydrolase, cholesterol-epoxide hydrolase, EH_CH

ECTree

     3 Hydrolases

         3.3 Acting on ether bonds

             3.3.2 Ether hydrolases

                3.3.2.11 cholesterol-5,6-oxide hydrolase

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Results	in table
6	Activating Compound
5	AA Sequence
2	Application
1	CAS Registry Number
12	Disease/ Diagnostics
1	Expression
9	General Information
24	IC50 Value
126	Inhibitors
62	Ki Value [mM]
10	KM Value [mM]
18	Localization
35	Natural Substrates/ Products (Substrates)
21	Organism
5	Oxidation Stability
11	pH Optimum
1	pH Range
12	Purification (Commentary)
4	Reaction
21	Reference
38	Source Tissue
21	Specific Activity [micromol/min/mg]
1	Storage Stability
57	Substrates and Products (Substrate)
27	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]

Oxidation Stability

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Oxidation Stability on EC 3.3.2.11 - cholesterol-5,6-oxide hydrolase

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OXIDATION STABILITY

ORGANISM

UNIPROT

LITERATURE

acetone reduces the activity by 85% at 1.25% v/v, by 50% at 3.75% v/v, and by 56% at 6.25% v/v

Rattus norvegicus

-

660782

acetonitrile activates the enzyme at moderate concentration, maximal enzyme activity at 6.25% v/v, 19% of maximal activity at 1.25% v/v, 50% of maximal activity at 12.5% v/v, no activity at 18.8% v/v

Rattus norvegicus

-

660782

dimethylsulfoxide reduces the activity by 42% at 6.25% v/v

Rattus norvegicus

-

660782

methanol reduces the activity by 86% at 3.75% v/v

Rattus norvegicus

-

660782

tetrahydrofuran reduces the activity by 86% at 6.25% v/v

Rattus norvegicus

-

660782