3.2.2.19: [protein ADP-ribosylarginine] hydrolase

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For detailed information about [protein ADP-ribosylarginine] hydrolase, go to the full flat file.

Word Map on EC 3.2.2.19

3.2.2.19

adp-ribosylation

nad:arginine

polyadp-ribose

mono-adp-ribosylation

pargs

arginine-specific

adp-ribose-arginine

macrodomains

nsp3

monoadp-ribosylated

mono-adp-ribosyltransferase

Reaction

Synonyms

AAH, ADP-ribose-L-arginine cleavage enzyme, ADP-ribose-L-arginine cleaving enzyme, ADP-ribosyl(arginine)protein hydrolase, ADP-ribosyl-acceptor hydrolase, ADP-ribosylarginine glycohydrolase, ADP-ribosylarginine hydrolase, ADP-ribosylhydrolase, ADP-ribosylhydrolase 1, ADP-ribosylhydrolase 3, ADP-ribosylhydrolase-like 1, ADPRH, AdprHl1, ARH1, ARH3, hARH1, mono-ADP-ribosyl-arginine hydrolase, More, Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase, O-acetyl-ADP-ribose hydrolase, PARG, poly(ADP-ribose) glycohydrolase, poly-(ADP-ribose) glycohydrolase, [protein ADP-ribosylarginine] hydrolase

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.2 Hydrolysing N-glycosyl compounds

3.2.2.19 [protein ADP-ribosylarginine] hydrolase

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Results	in table
17	Activating Compound
69	AA Sequence
1	CAS Registry Number
19	Cloned(Commentary)
3	Crystallization (Commentary)
46	Disease/ Diagnostics
3	General Information
2	IC50 Value
40	Inhibitors
1	Ki Value [mM]
6	KM Value [mM]
4	Localization
29	Metals/Ions
28	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
61	Organism
4	PDB ID
2	pH Optimum
5	Protein Variants
29	Purification (Commentary)
2	Reaction
4	Reaction Type
61	Reference
65	Source Tissue
16	Specific Activity [micromol/min/mg]
52	Substrates and Products (Substrate)
4	Subunits
32	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Purification

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Purification on EC 3.2.2.19 - [protein ADP-ribosylarginine] hydrolase

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2 entries

20000 fold by DE-52, phenyl-Sepharose, hydroxylapatite, Affi-Gel 501 organo-mercurial agarose, Ultrogel AcA 54

Rattus norvegicus

137041, 137044, 137047

200000fold by DE-52, phenyl-Sepharose, hydroxylapatite, Ultrogel AcA 54, Mono Q chromatography

Meleagris gallopavo

137039, 137044, 137047

800fold by DE-52, phenyl-Sepharose, carboxymethylcellulose, organomercurial agarose, Ultrogel AcA 54

Meleagris gallopavo

137038

as a GST-fusion protein almost to homogeneity by affinity-column chromatography of glutathione-Sepharose

Rattus norvegicus

137043

depending on the procedure used for purification, either a thiol-resistant or a thiol-sensitive species can be isolated. Organomercurial chromatography apparently results in the formation of the thiol-sensitive species of hydrolase as the exposure of the thiol-resistant form to HgCl2 does

Meleagris gallopavo

137039

homogenate of chicken muscle cells from tissue culture was centrifugated and the supernatant dialyzed

Gallus gallus

137040

partial

8 entries

partial by successive chromatography on DE-52 cellulose, phenyl-Sepharose and organomercurial agarose

Meleagris gallopavo

137037, 137044

recombinant His-tagged hARH1 from Escherichia coli strain BL21(DE3) by nickel affinity chromatography, ultrafiltration, and gel filtration

Homo sapiens

P54944

706972

using glutathione-Sepharose 4B

Mus musculus

683871

using His-Bind metal chelation resin

Rattus norvegicus

683619