3.2.2.19: [protein ADP-ribosylarginine] hydrolase

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For detailed information about [protein ADP-ribosylarginine] hydrolase, go to the full flat file.

Reaction

Synonyms

AAH, ADP-ribose-L-arginine cleavage enzyme, ADP-ribose-L-arginine cleaving enzyme, ADP-ribosyl(arginine)protein hydrolase, ADP-ribosyl-acceptor hydrolase, ADP-ribosylarginine glycohydrolase, ADP-ribosylarginine hydrolase, ADP-ribosylhydrolase, ADP-ribosylhydrolase 1, ADP-ribosylhydrolase 3, ADP-ribosylhydrolase-like 1, ADPRH, AdprHl1, ARH1, ARH3, hARH1, mono-ADP-ribosyl-arginine hydrolase, More, Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase, O-acetyl-ADP-ribose hydrolase, PARG, poly(ADP-ribose) glycohydrolase, poly-(ADP-ribose) glycohydrolase, [protein ADP-ribosylarginine] hydrolase

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.2 Hydrolysing N-glycosyl compounds

                3.2.2.19 [protein ADP-ribosylarginine] hydrolase

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Results	in table
17	Activating Compound
69	AA Sequence
1	CAS Registry Number
19	Cloned(Commentary)
3	Crystallization (Commentary)
46	Disease/ Diagnostics
3	General Information
2	IC50 Value
40	Inhibitors
1	Ki Value [mM]
6	KM Value [mM]
4	Localization
29	Metals/Ions
28	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
61	Organism
4	PDB ID
2	pH Optimum
5	Protein Variants
29	Purification (Commentary)
2	Reaction
4	Reaction Type
61	Reference
65	Source Tissue
16	Specific Activity [micromol/min/mg]
52	Substrates and Products (Substrate)
4	Subunits
32	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Disease

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Disease on EC 3.2.2.19 - [protein ADP-ribosylarginine] hydrolase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Ataxia

Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome.

30100084, 30388405

Ataxia

Novel imaging and clinical phenotypes of CONDSIAS disorder caused by a homozygous frameshift variant of ADPRHL2: a case report.

32746785

Breast Neoplasms

Variations in the mRNA expression of poly(ADP-ribose) polymerases, poly(ADP-ribose) glycohydrolase and ADP-ribosylhydrolase 3 in breast tumors and impact on clinical outcome.

23736962

Carcinogenesis

ADP-Ribosylarginine Hydrolase Regulates Cell Proliferation and Tumorigenesis.

21697277

Carcinogenesis

ADPRH is a prognosis-related biomarker and correlates with immune infiltrates in low grade glioma.

33854592

Cholera

ADP-ribosylarginine glycohydrolase catalyzing the release of ADP-ribose from the cholera toxin-modified alpha-subunits of GTP-binding proteins.

7896743

Cholera

Enhanced sensitivity to cholera toxin in female ADP-ribosylarginine hydrolase (ARH1)-deficient mice.

30500844

Communicable Diseases

Macrodomain ADP-ribosylhydrolase and the pathogenesis of infectious diseases.

29566066

Cystic Fibrosis

A comprehensive review of therapeutic approaches available for the treatment of cholera.

32737883

Glioma

ADPRH is a prognosis-related biomarker and correlates with immune infiltrates in low grade glioma.

33854592

Infections

An MHV macrodomain mutant predicted to lack ADP-ribose binding activity is severely attenuated, indicating multiple roles for the macrodomain in coronavirus replication.

33821264

Melanoma

Co-expression modules construction by WGCNA and identify potential prognostic markers of uveal melanoma.

29031853

Neoplasms

ADP-Ribosylarginine Hydrolase Regulates Cell Proliferation and Tumorigenesis.

21697277

Neoplasms

ADPRH is a prognosis-related biomarker and correlates with immune infiltrates in low grade glioma.

33854592

Neoplasms

Variations in the mRNA expression of poly(ADP-ribose) polymerases, poly(ADP-ribose) glycohydrolase and ADP-ribosylhydrolase 3 in breast tumors and impact on clinical outcome.

23736962

Seizures

Novel imaging and clinical phenotypes of CONDSIAS disorder caused by a homozygous frameshift variant of ADPRHL2: a case report.

32746785

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