3.2.2.19: [protein ADP-ribosylarginine] hydrolase

This is an abbreviated version!
For detailed information about [protein ADP-ribosylarginine] hydrolase, go to the full flat file.

Reaction

Synonyms

AAH, ADP-ribose-L-arginine cleavage enzyme, ADP-ribose-L-arginine cleaving enzyme, ADP-ribosyl(arginine)protein hydrolase, ADP-ribosyl-acceptor hydrolase, ADP-ribosylarginine glycohydrolase, ADP-ribosylarginine hydrolase, ADP-ribosylhydrolase, ADP-ribosylhydrolase 1, ADP-ribosylhydrolase 3, ADP-ribosylhydrolase-like 1, ADPRH, AdprHl1, ARH1, ARH3, hARH1, mono-ADP-ribosyl-arginine hydrolase, More, Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase, O-acetyl-ADP-ribose hydrolase, PARG, poly(ADP-ribose) glycohydrolase, poly-(ADP-ribose) glycohydrolase, [protein ADP-ribosylarginine] hydrolase

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.2 Hydrolysing N-glycosyl compounds

                3.2.2.19 [protein ADP-ribosylarginine] hydrolase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
17	Activating Compound
69	AA Sequence
1	CAS Registry Number
19	Cloned(Commentary)
3	Crystallization (Commentary)
46	Disease/ Diagnostics
3	General Information
2	IC50 Value
40	Inhibitors
1	Ki Value [mM]
6	KM Value [mM]
4	Localization
29	Metals/Ions
28	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
61	Organism
4	PDB ID
2	pH Optimum
5	Protein Variants
29	Purification (Commentary)
2	Reaction
4	Reaction Type
61	Reference
65	Source Tissue
16	Specific Activity [micromol/min/mg]
52	Substrates and Products (Substrate)
4	Subunits
32	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Substrates Products on EC 3.2.2.19 - [protein ADP-ribosylarginine] hydrolase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Substrate/Product Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2'-O-acetyl-ADP-ribose + H2O

ADP-ribose + acetate

Homo sapiens

-

-

682516

-

-

?

2'-phospho-ADP-ribosylarginine + H2O

2'-phospho-ADP-ribose + arginine

Meleagris gallopavo

-

-

137038

-

137038

?

ADP-ribose DABSYL-L-arginine methyl ester + H2O

DABSYL-L-arginine methyl ester + ADP-ribose

3 entries

ADP-ribose-arginine + H2O

ADP-ribose + arginine

10 entries

ADP-ribose-L-arginine + H2O

ADP-ribose + L-arginine

6 entries

ADP-ribosylarginine + H2O

ADP-ribose + L-arginine

2 entries

ADP-ribosylarginine methyl ester + H2O

ADP-ribose + arginine methyl ester

Rattus norvegicus

-

-

137043

-

137043

?

ADP-ribosylguanidine + H2O

ADP-ribose + guanidine

Meleagris gallopavo

-

at pH less than 7, the enzme exhibits more activity toward ADP-ribosylguanidine than toward ADP-ribosylarginine. The ratio of activity in assays containing ADP-ribosylarginine to those with ADP-ribosylguanidine increases with pH

137038

-

137038

?

alpha-subunit of stimulating GTP-binding protein ADP-ribosylated + H2O

alpha-subunit of stimulating GTP-binding protein + ADP-ribose

2 entries

casein ADP-ribosylated + H2O

ADP-ribose + casein

Rattus norvegicus

-

-

137045

-

137045

?

cholera toxin A1-subunit ADP-ribosylated + H2O

cholera toxin A1-subunit + ADP-ribose

2 entries

histones ADP-ribosylated + H2O

?

Mus musculus

-

-

137044

-

-

?

lysozyme ADP-ribosylated + H2O

?

Rattus norvegicus

-

-

137044

-

-

?

maltose binding protein ADP-ribosylated + H2O

maltose binding protein + ADP-ribose

Rattus norvegicus

-

MBP is ADP-ribosylated by an arginine-specific ADP-ribosyltransferase cholera toxin

137045

-

137045

?

Nomega-(ADP-D-ribosyl)-L-arginine + H2O

ADP-ribose + L-arginine

2 entries

nonmuscle actin ADP-ribosylated + H2O

nonmuscle actin + ADP-ribose

2 entries

O-acetyl-ADP-ribose + H2O

ADP-ribose + acetate

Mus musculus

-

the reaction is catalyzed by isoform ARH3 only

731708

-

-

?

protein-Nomega-(ADP-D-ribosyl)-L-arginine + H2O

ADP-ribose + protein-L-arginine

2 entries

additional information

?

-

4 entries

ADP-ribose DABSYL-L-arginine methyl ester + H2O

DABSYL-L-arginine methyl ester + ADP-ribose

Gallus gallus

-

-

137040

-

137040

?

ADP-ribose DABSYL-L-arginine methyl ester + H2O

DABSYL-L-arginine methyl ester + ADP-ribose

Oryctolagus cuniculus

-

-

137040

-

137040

?

ADP-ribose DABSYL-L-arginine methyl ester + H2O

DABSYL-L-arginine methyl ester + ADP-ribose

Rattus norvegicus

-

-

137040

-

137040

?

ADP-ribose-arginine + H2O

ADP-ribose + arginine

Gallus gallus

-

ADP-ribosylarginine hydrolase presumably regenerates an arginine site that can be ADP-ribosylated by NAD-arginine ADP-ribosyltransferase. The balance between these two opposing enzymatic activities may control some aspects of cellular metabolism

137040

-

-

?

ADP-ribose-arginine + H2O

ADP-ribose + arginine

Meleagris gallopavo

-

-

137039, 137042, 137044, 137047, 137048

-

-

?

ADP-ribose-arginine + H2O

ADP-ribose + arginine

Meleagris gallopavo

-

the presence of ADP-ribosyltransferases and ADP-ribosylhydrolases may lead to an ADP-ribosylation/de-ADP-ribosylation cycle, lending further support to the hypothesis that this covalent modification may have a regulatory function in animal cells

137037

-

137037

?

ADP-ribose-arginine + H2O

ADP-ribose + arginine

Meleagris gallopavo

-

the presence of different enzymes and effectors controlling ADP-ribosylarginine synthesis and degradation is reminiscent of the protein kinase-phosphatase system

137038

-

-

?

ADP-ribose-arginine + H2O

ADP-ribose + arginine

Mus musculus

-

-

731708

-

-

?

ADP-ribose-arginine + H2O

ADP-ribose + arginine

Rattus norvegicus

-

the presence of ecto-ADP-ribosyltransferase and arginine-specific ADP-ribosylation of cell-surface protein have been reported. Application of the method on the extracellular ADP-ribosylation of intact cells may help to reveal the role of the modification in physiological events such as cell adhesion or cell-cell communication

137045

-

-

?

ADP-ribose-arginine + H2O

ADP-ribose + arginine

Rhodospirillum rubrum

-

-

137037

-

-

?

ADP-ribose-arginine + H2O

ADP-ribose + arginine

Rhodospirillum rubrum

-

in Rhodospirillium rubrum, a nitrogen-fixing microorganism, ADP-ribosylation of an arginine residue in a nitrogenase inhibits its activity. Inactivation of the nitrogenase can be reversed by a hydrolase which cleaves the ADP-ribose-arginine bond

137039

-

-

?

ADP-ribose-arginine + H2O

ADP-ribose + arginine

Rhodospirillum rubrum

-

in nitrogen fixing bacteria, Rhodospirillium rubrum, ADP-ribosylation-de-ADP-ribosylation of a specific arginine-residue of dinitrogenase reductase has been shown to regulate the enzyme activity

137046

-

-

?

ADP-ribose-arginine + H2O

ADP-ribose + arginine

Rhodospirillum rubrum

-

the existence of a ADP-ribosylation cycle was established in the bacterium Rhodospirillium rubrum where it regulates dinitrogenase reductase, a key enzyme in nitrogen fixation

137040, 137042, 137044, 137045, 137047, 137048

-

-

?

ADP-ribose-L-arginine + H2O

ADP-ribose + L-arginine

Homo sapiens

-

-

137042

-

-

?

ADP-ribose-L-arginine + H2O

ADP-ribose + L-arginine

Meleagris gallopavo

-

-

137037

-

137037

?

ADP-ribose-L-arginine + H2O

ADP-ribose + L-arginine

Meleagris gallopavo

-

-

137038

-

137038

?

ADP-ribose-L-arginine + H2O

ADP-ribose + L-arginine

Meleagris gallopavo

-

-

137042

-

137042

?

ADP-ribose-L-arginine + H2O

ADP-ribose + L-arginine

Rattus norvegicus

-

-

137042

-

-

?

ADP-ribose-L-arginine + H2O

ADP-ribose + L-arginine

Rattus norvegicus

-

as a GST-fusion protein, ADP-ribosylarginine formed by chicken heterophil arginine-specific ADP-ribosyltransferase

137045

-

-

?

ADP-ribosylarginine + H2O

ADP-ribose + L-arginine

Homo sapiens

-

-

137042

-

-

?

ADP-ribosylarginine + H2O

ADP-ribose + L-arginine

Meleagris gallopavo

-

-

137038

-

-

?

alpha-subunit of stimulating GTP-binding protein ADP-ribosylated + H2O

alpha-subunit of stimulating GTP-binding protein + ADP-ribose

Rattus norvegicus

-

-

137047

-

137047

?

alpha-subunit of stimulating GTP-binding protein ADP-ribosylated + H2O

alpha-subunit of stimulating GTP-binding protein + ADP-ribose

Rattus norvegicus

-

the GDP-bound form of ADP-ribosylated stimulating GTP-binding protein-alpha is more rapidly hydrolyzed than the GTPgammaS-bound form

137043

-

137043

?

cholera toxin A1-subunit ADP-ribosylated + H2O

cholera toxin A1-subunit + ADP-ribose

Rattus norvegicus

-

-

137043

-

137043

?

cholera toxin A1-subunit ADP-ribosylated + H2O

cholera toxin A1-subunit + ADP-ribose

Rattus norvegicus

-

-

137047

-

137047

?

Nomega-(ADP-D-ribosyl)-L-arginine + H2O

ADP-ribose + L-arginine

Mus musculus

-

-

683871

-

-

?

Nomega-(ADP-D-ribosyl)-L-arginine + H2O

ADP-ribose + L-arginine

Rattus norvegicus

-

-

683619

-

-

?

nonmuscle actin ADP-ribosylated + H2O

nonmuscle actin + ADP-ribose

Rattus norvegicus

-

-

137043

-

137043

?

nonmuscle actin ADP-ribosylated + H2O

nonmuscle actin + ADP-ribose

Rattus norvegicus

-

-

137047

-

137047

?

protein-Nomega-(ADP-D-ribosyl)-L-arginine + H2O

ADP-ribose + protein-L-arginine

Mus musculus

-

-

683871

-

-

?

protein-Nomega-(ADP-D-ribosyl)-L-arginine + H2O

ADP-ribose + protein-L-arginine

Rattus norvegicus

-

-

683619

-

-

?

additional information

?

-

Homo sapiens

-

structure-function relationship, overview

709521

-

-

?

additional information

?

-

Homo sapiens

P54944

ADPRH cleaves the glycosidic bond of ADP-ribose attached to an Arg residue of a protein

706972

-

-

?

additional information

?

-

Homo sapiens

-

ADPRH cleaves the glycosidic bond of ADP-ribose attached to an Arg residue of a protein

706972

-

-

?

additional information

?

-

Mus musculus

-

isoform ARH1 catalyzes the hydrolysis of the N-glycosidic bond of mono-(ADP-ribosyl)ated arginine, while isoform ARH3 hydrolyzes poly-(ADP-ribose) and O-acetyl-ADP-ribose

731708

-

-

?