3.2.2.19: [protein ADP-ribosylarginine] hydrolase
This is an abbreviated version!
For detailed information about [protein ADP-ribosylarginine] hydrolase, go to the full flat file.
Word Map on EC 3.2.2.19
-
3.2.2.19
-
adp-ribosylation
-
nad:arginine
-
polyadp-ribose
-
mono-adp-ribosylation
-
pargs
-
arginine-specific
-
adp-ribose-arginine
-
macrodomains
-
nsp3
-
monoadp-ribosylated
-
mono-adp-ribosyltransferase
- 3.2.2.19
-
adp-ribosylation
-
nad:arginine
-
polyadp-ribose
-
mono-adp-ribosylation
-
pargs
-
arginine-specific
- adp-ribose-arginine
-
macrodomains
- nsp3
-
monoadp-ribosylated
- mono-adp-ribosyltransferase
Reaction
Synonyms
AAH, ADP-ribose-L-arginine cleavage enzyme, ADP-ribose-L-arginine cleaving enzyme, ADP-ribosyl(arginine)protein hydrolase, ADP-ribosyl-acceptor hydrolase, ADP-ribosylarginine glycohydrolase, ADP-ribosylarginine hydrolase, ADP-ribosylhydrolase, ADP-ribosylhydrolase 1, ADP-ribosylhydrolase 3, ADP-ribosylhydrolase-like 1, ADPRH, AdprHl1, ARH1, ARH3, hARH1, mono-ADP-ribosyl-arginine hydrolase, More, Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase, O-acetyl-ADP-ribose hydrolase, PARG, poly(ADP-ribose) glycohydrolase, poly-(ADP-ribose) glycohydrolase, [protein ADP-ribosylarginine] hydrolase
ECTree
3.2.2.19 [protein ADP-ribosylarginine] hydrolaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 3.2.2.19 - [protein ADP-ribosylarginine] hydrolase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
O-acetyl-ADP-ribose + H2O
ADP-ribose + acetate
-
the reaction is catalyzed by isoform ARH3 only
-
-
?
ADP-ribose-arginine + H2O
ADP-ribose + arginine
-
ADP-ribosylarginine hydrolase presumably regenerates an arginine site that can be ADP-ribosylated by NAD-arginine ADP-ribosyltransferase. The balance between these two opposing enzymatic activities may control some aspects of cellular metabolism
-
-
?
ADP-ribose-arginine + H2O
ADP-ribose + arginine
-
-
-
-
?
ADP-ribose-arginine + H2O
ADP-ribose + arginine
-
the presence of ADP-ribosyltransferases and ADP-ribosylhydrolases may lead to an ADP-ribosylation/de-ADP-ribosylation cycle, lending further support to the hypothesis that this covalent modification may have a regulatory function in animal cells
-
?
ADP-ribose-arginine + H2O
ADP-ribose + arginine
-
the presence of different enzymes and effectors controlling ADP-ribosylarginine synthesis and degradation is reminiscent of the protein kinase-phosphatase system
-
-
?
ADP-ribose-arginine + H2O
ADP-ribose + arginine
-
the presence of ecto-ADP-ribosyltransferase and arginine-specific ADP-ribosylation of cell-surface protein have been reported. Application of the method on the extracellular ADP-ribosylation of intact cells may help to reveal the role of the modification in physiological events such as cell adhesion or cell-cell communication
-
-
?
ADP-ribose-arginine + H2O
ADP-ribose + arginine
-
in Rhodospirillium rubrum, a nitrogen-fixing microorganism, ADP-ribosylation of an arginine residue in a nitrogenase inhibits its activity. Inactivation of the nitrogenase can be reversed by a hydrolase which cleaves the ADP-ribose-arginine bond
-
-
?
ADP-ribose-arginine + H2O
ADP-ribose + arginine
-
in nitrogen fixing bacteria, Rhodospirillium rubrum, ADP-ribosylation-de-ADP-ribosylation of a specific arginine-residue of dinitrogenase reductase has been shown to regulate the enzyme activity
-
-
?
ADP-ribose-arginine + H2O
ADP-ribose + arginine
-
the existence of a ADP-ribosylation cycle was established in the bacterium Rhodospirillium rubrum where it regulates dinitrogenase reductase, a key enzyme in nitrogen fixation
-
-
?
protein-Nomega-(ADP-D-ribosyl)-L-arginine + H2O
ADP-ribose + protein-L-arginine
-
-
-
-
?
protein-Nomega-(ADP-D-ribosyl)-L-arginine + H2O
ADP-ribose + protein-L-arginine
-
-
-
-
?
additional information
?
-
ADPRH cleaves the glycosidic bond of ADP-ribose attached to an Arg residue of a protein
-
-
?
additional information
?
-
-
ADPRH cleaves the glycosidic bond of ADP-ribose attached to an Arg residue of a protein
-
-
?
