Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D77/78N | mutant does not hydrolyze poly(ADP-ribose) | Homo sapiens |
E238/239Q | mutant hydrolyzes O-acetyl-ADP-ribose at rates similar to that of the wild-type | Homo sapiens |
E261/262Q | mutant hydrolyzes O-acetyl-ADP-ribose at rates similar to that of the wild-type | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP-ribose | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
39000 | - |
- |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2'-O-acetyl-ADP-ribose + H2O | Homo sapiens | - |
ADP-ribose + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2'-O-acetyl-ADP-ribose + H2O | - |
Homo sapiens | ADP-ribose + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ARH3 | - |
Homo sapiens |
O-acetyl-ADP-ribose hydrolase | - |
Homo sapiens |
poly-(ADP-ribose) glycohydrolase | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
hydrolysis of O-acetyl-[14C]ADP-ribose catalyzed by ARH3 | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
ADP-ribose | competitive inhibition | Homo sapiens |