3.2.2.19: [protein ADP-ribosylarginine] hydrolase

This is an abbreviated version!
For detailed information about [protein ADP-ribosylarginine] hydrolase, go to the full flat file.

Word Map on EC 3.2.2.19

3.2.2.19

adp-ribosylation

nad:arginine

polyadp-ribose

mono-adp-ribosylation

pargs

arginine-specific

adp-ribose-arginine

macrodomains

nsp3

monoadp-ribosylated

mono-adp-ribosyltransferase

Reaction

Synonyms

AAH, ADP-ribose-L-arginine cleavage enzyme, ADP-ribose-L-arginine cleaving enzyme, ADP-ribosyl(arginine)protein hydrolase, ADP-ribosyl-acceptor hydrolase, ADP-ribosylarginine glycohydrolase, ADP-ribosylarginine hydrolase, ADP-ribosylhydrolase, ADP-ribosylhydrolase 1, ADP-ribosylhydrolase 3, ADP-ribosylhydrolase-like 1, ADPRH, AdprHl1, ARH1, ARH3, hARH1, mono-ADP-ribosyl-arginine hydrolase, More, Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase, O-acetyl-ADP-ribose hydrolase, PARG, poly(ADP-ribose) glycohydrolase, poly-(ADP-ribose) glycohydrolase, [protein ADP-ribosylarginine] hydrolase

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.2 Hydrolysing N-glycosyl compounds

3.2.2.19 [protein ADP-ribosylarginine] hydrolase

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Results	in table
17	Activating Compound
69	AA Sequence
1	CAS Registry Number
19	Cloned(Commentary)
3	Crystallization (Commentary)
46	Disease/ Diagnostics
3	General Information
2	IC50 Value
40	Inhibitors
1	Ki Value [mM]
6	KM Value [mM]
4	Localization
29	Metals/Ions
28	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
61	Organism
4	PDB ID
2	pH Optimum
5	Protein Variants
29	Purification (Commentary)
2	Reaction
4	Reaction Type
61	Reference
65	Source Tissue
16	Specific Activity [micromol/min/mg]
52	Substrates and Products (Substrate)
4	Subunits
32	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 3.2.2.19 - [protein ADP-ribosylarginine] hydrolase

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adenosine 5'-diphosphate(hydroxymethyl)pyrrolidinediol

ADP

ADP-ribose

ADP-ribosylarginine methyl ester

ADPribose

alphaNAD+

AMP

137038, 137044, 137047

Arginine methyl ester

3 entries

betaNAD+

Meleagris gallopavo

inhibition by alphaNAD+ stronger than by betaNAD+

CaCl2

dithiothreitol

incubation in 20 mM at 37°C leads to rapid loss of activity but addition of Mg2+ stabilizes the hydrolase against thermal inactivation

137038, 137044

N-ethylmaleimide

Meleagris gallopavo

after incubation with dithiothreitol at 30°C the thiol-sensitive and the thiol-resistant hydrolase are inactivated by NEM at 4°C , exposure to dithiothreitol at 4°C is sufficient to permit subsequent inactivation of the thiol-sensitive but not the thiol-resistant form by NEM

137039

NaCl

Meleagris gallopavo

inhibition with 200 mM

137038, 137047

NAD+

Meleagris gallopavo

10 mM Mg2+ or 10 mM Mg2+ plus 5 mM dithiothreitol reduces the extent of inactivation of thiol-sensitive and thiol-resistant hydrolase by NAD+

137039

NAD-arginine ADP-ribosyltransferase

Meleagris gallopavo

10 mM Mg2+ or 10 mM Mg2+ plus 5 mM dithiothreitol reduces the extent of inactivation of thiol-sensitive and thiol-resistant hydrolase by NAD-arginine ADP-ribosyltransferase

137039

NaF

Meleagris gallopavo

more than 80% inhibition with 5 mM

137038, 137047