3.2.1.52: beta-N-acetylhexosaminidase This is an abbreviated version! For detailed information about beta-N-acetylhexosaminidase, go to the full flat file .
Reaction
(N-acetyl-D-glucosamine)4 +
3 H2O
=
4 2-(acetylamino)-2-deoxy-beta-D-glucopyranose
Synonyms 2-acetamido-2-deoxy-beta-D-glucoside acetamidodeoxyglucohydrolase, 3-beta-N-acetylglucosaminidase, 65 kDa epididymal boar protein, Am2301, Am2446, At1g65600/F5I14_13, beta-acetylaminodeoxyhexosidase, beta-acetylhexosaminidase, beta-acetylhexosaminidinase, beta-D-hexosaminidase, beta-D-N-acetylhexosaminidase, Beta-GlcNAcase, beta-glucosidase, beta-HEX, beta-HexNAcase, beta-hexosaminidase, beta-hexosaminidase A, beta-hexosaminidase B, beta-hexosaminidase I, beta-hexosaminidase II, beta-N-acetyl-D-glucosaminidase, beta-N-acetyl-D-hexosaminidase, beta-N-acetyl-hexosaminidase, beta-N-acetylgalactosaminidase, beta-N-acetylglucosaminidase, Beta-N-acetylhexosaminidase, beta-N-acetylhexosaminidase A, beta-N-acetylhexosaminidase B, beta-Nacetylhexosaminidase S, beta-NAGase, beta-NAHA, Beta-NAHASE, bifunctional exo-beta-glucosidase/N-acetyl-beta-glucosaminidase, BmCHI-h, BmGlcNAcase 1, BmGlcNAcase 2, BmNPV CHIA, CbsA, Chi-I, Chi-II, chitobiase, chitobiase 2, CpGV V-CHIA, dispersin B, DmHEXA, DmHEXB, DspB, EC 3.2.1.29, EC 3.2.1.30, endo-beta-N-acetylglucosaminidase, EXC1Y, EXC2Y, exo-acting chitinase, exo-beta-D-N-acetylglucosaminidase, exo-beta-hexosaminidase, exo-type beta-N-acetylhexosaminidase, exochitinase, F3F20.4 protein, FDL, GH84C, GlcNAcase, Hex, Hex A, Hex B, Hex-1, Hex1, Hex2, Hex20, Hex4, HexB, HexD, HEXDC, hEXO1, HEXO2, HEXO3, hexosaminidase, hexosaminidase A, hexosaminidase B, hexosaminidase D, hHexA, lacto-N-biosidase, lnba, lysosomal beta-hexosaminidase, More, N-acetyl-beta-D-hexosaminidase, N-acetyl-beta-glucosaminidase, N-acetyl-beta-hexosaminidase, N-acetylglucosaminidase, N-acetylhexosaminidase, NAG-68, NAG-B, NAG1, NAG2, Nag3, NagA, NAGase, NagJ, NagZ, NAHA, NAHase, neutral hexosaminidase C, O-GlcNAcase, Pcb-NAHA1, Sfhex, SSO3039, StrH, zymocin alpha-subunit
ECTree
Application
Application on EC 3.2.1.52 - beta-N-acetylhexosaminidase
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analysis
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comparison of glycolytic and chitinolytic enzyme activities between desert and oasis flies of Phlebotomus papatasi to evaluate potential differences in susceptibility to infection with Leishmania major
diagnostics
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a spectrophotometric method for the determination of lysosomally derived N-acetyl-beta-D-hexosaminidase in synovial fluid on a microplate reader is optimized to improve its utility. The assay is sufficiently sensitive for small volumes of synovial fluid, and is useful for the clinical diagnosis of joint diseases
drug development
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the enzyme is a target for GlcNAc-inspired iminocyclitiols drug development
food industry
silencing of alpha-mannosidase and beta-D-N-acetylhexosaminidase enhances fruit shelf life due to the reduced degradation of N-glycoproteins which result in delayed softening
medicine
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diagosis of Tay-Sachs disease
medicine
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veterinary medicine: increased level of enzyme in secreted milk can be detected by diagnosis test for mastitis of the mammary gland of cows
medicine
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therapeutic approach for Sandhoff disease
medicine
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drugs inhibiting N-acetyl-beta-D-hexosaminidase activity, such as iminocyclitols, may be useful in cholesteatoma treatment
medicine
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enzyme enhancement therapy utilizing small molecules as pharmacological chaperones is a promising therapeutic approach to treat late-onset forms of Tay-Sachs disease and Sandhoff disease, as well as other lysosomal storage diseases
medicine
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N-acetyl-beta-hexosaminidase may be considered as a new tumour marker in pleomorphic adenoma
medicine
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2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol, N-benzyl-2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol, and N-butyl-2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol are potent and selective inhibitors of beta-N-acetylhexosaminidase and may be useful as therapeutic agents for treating adult Tay-Sachs and Sandhoff diseases
medicine
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activity of HEX and its isoenzyme A determined in the serum and urine can be used as a potential marker of pancreatic adenocarcinoma
medicine
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GlcNAcase may be an important factor in the formation of paucimannosidic core N-glycans in Drosophila S2 cells. It may be possible to express complex glycoproteins in engineered Drosophila S2 cells by suppressing GlcNAcase in the N-glycosylation pathway
medicine
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HEX and its isoenzymes' activity significantly correlate with the progression of lactation
medicine
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HEX is present in larynx cancer tissue
additional information
FDL may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
FDL may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
FDL may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
FDL may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
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FDL may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
Hex1 may be mostly involved in insect chitin catabolism and may be a specific target for pesticide development
additional information
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Hex1 may be mostly involved in insect chitin catabolism and may be a specific target for pesticide development
additional information
NAG1 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
NAG1 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
NAG1 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
NAG1 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
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NAG1 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
NAG2 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
NAG2 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
NAG2 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
NAG2 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
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NAG2 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
NAG3 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
NAG3 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
NAG3 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
NAG3 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
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NAG3 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
additional information
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NAG1 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
-
additional information
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NAG2 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
-
additional information
-
NAG3 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
-
additional information
-
FDL may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development
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