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3.2.1.52: beta-N-acetylhexosaminidase

This is an abbreviated version!
For detailed information about beta-N-acetylhexosaminidase, go to the full flat file.

Word Map on EC 3.2.1.52

Reaction

(N-acetyl-D-glucosamine)4
+ 3 H2O = 4 2-(acetylamino)-2-deoxy-beta-D-glucopyranose

Synonyms

2-acetamido-2-deoxy-beta-D-glucoside acetamidodeoxyglucohydrolase, 3-beta-N-acetylglucosaminidase, 65 kDa epididymal boar protein, Am2301, Am2446, At1g65600/F5I14_13, beta-acetylaminodeoxyhexosidase, beta-acetylhexosaminidase, beta-acetylhexosaminidinase, beta-D-hexosaminidase, beta-D-N-acetylhexosaminidase, Beta-GlcNAcase, beta-glucosidase, beta-HEX, beta-HexNAcase, beta-hexosaminidase, beta-hexosaminidase A, beta-hexosaminidase B, beta-hexosaminidase I, beta-hexosaminidase II, beta-N-acetyl-D-glucosaminidase, beta-N-acetyl-D-hexosaminidase, beta-N-acetyl-hexosaminidase, beta-N-acetylgalactosaminidase, beta-N-acetylglucosaminidase, Beta-N-acetylhexosaminidase, beta-N-acetylhexosaminidase A, beta-N-acetylhexosaminidase B, beta-Nacetylhexosaminidase S, beta-NAGase, beta-NAHA, Beta-NAHASE, bifunctional exo-beta-glucosidase/N-acetyl-beta-glucosaminidase, BmCHI-h, BmGlcNAcase 1, BmGlcNAcase 2, BmNPV CHIA, CbsA, Chi-I, Chi-II, chitobiase, chitobiase 2, CpGV V-CHIA, dispersin B, DmHEXA, DmHEXB, DspB, EC 3.2.1.29, EC 3.2.1.30, endo-beta-N-acetylglucosaminidase, EXC1Y, EXC2Y, exo-acting chitinase, exo-beta-D-N-acetylglucosaminidase, exo-beta-hexosaminidase, exo-type beta-N-acetylhexosaminidase, exochitinase, F3F20.4 protein, FDL, GH84C, GlcNAcase, Hex, Hex A, Hex B, Hex-1, Hex1, Hex2, Hex20, Hex4, HexB, HexD, HEXDC, hEXO1, HEXO2, HEXO3, hexosaminidase, hexosaminidase A, hexosaminidase B, hexosaminidase D, hHexA, lacto-N-biosidase, lnba, lysosomal beta-hexosaminidase, More, N-acetyl-beta-D-hexosaminidase, N-acetyl-beta-glucosaminidase, N-acetyl-beta-hexosaminidase, N-acetylglucosaminidase, N-acetylhexosaminidase, NAG-68, NAG-B, NAG1, NAG2, Nag3, NagA, NAGase, NagJ, NagZ, NAHA, NAHase, neutral hexosaminidase C, O-GlcNAcase, Pcb-NAHA1, Sfhex, SSO3039, StrH, zymocin alpha-subunit

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.52 beta-N-acetylhexosaminidase

Activating Compound

Activating Compound on EC 3.2.1.52 - beta-N-acetylhexosaminidase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
blocks inhibition by Hg2+-ions
acetate
-
untreated, concentration of 50 mM: activity reaches 170%
bovine serum albumin
-
chondroitin 4-sulfate
-
0.025 mg/ml, 1.19fold activation
chondroitin 6-sulfate
cysteine
D-fructose
-
58% activation at 3 mM
D-galactosamine
D-galactose
-
80% activation at 3 mM
D-glucosamine
D-glucose
-
64% activation at 3 mM
D-glucuronic acid
-
65% activation at 3 mM
diethyldicarbonate
-
37% activation at 1 mM
dithioerythritol
-
presence decreases extent of inactivation by Hg2+, Ag2+, thimerosal or p-hydroxymercuribenzoate
dithiothreitol
-
stimulates N-acetylglucosaminidase even at low concentrations
Fe3+
-
stimulates galactosaminidase activitiy of form I
glutathione
Glycopeptide
-
dimeric
GM12 activator protein
-
-
-
heparin
-
60% activation at 3 mM
Human serum albumin
-
-
-
L-cysteine
lactose
-
71% activation at 3 mM
low molecular weight protein
-
restores the enzyme's ability to hydrolyze GM2 in high ionic strength
-
maltose
-
56% activation at 3 mM
N-acetyl-glucosamine
-
0.05% (w/v)
N-acetylgalactosamine
-
9% activation at 3 mM
N-acetylglucosamine
N-benzyl-2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol
-
enhancement of beta-N-acetylhexosaminidase B activity at higher concentrations of inhibitor, whereas beta-N-acetylhexosaminidase A and/or beta-N-acetylhexosaminidase S activity are increased at much lower concentrations
N-ethylmaleimide
neutral N-acetylglucosaminidase
-
stimulates GM2-hydrolysis by N-acetylgalactosaminidase
-
p-nitrophenyl-N-acetyl-beta-D-galactosaminide
-
presence at a concentration 10 times that of p-hydroxymercuribenzoate lowers loss of galactosaminidase-activity by 25.5%
p-nitrophenyl-N-acetyl-beta-D-glucosaminide
-
presence at a concentration 50 times that of Hg2+, Ag+, thimerosal or p-hydroxymercuribenzoate reduces loss of glucosaminidase-activity by 20.5%
Phenylmethylsulfonylfluoride
-
1 mM, 1.46fold activation
PMSF
-
74% activation at 1 mM
sucrose
-
44% activation at 3 mM
taurocholate
-
concentrations of 0.05 M and 0.1 M cause 140% and 160% of activity
Triton X-100
-
prevents loss of activity caused by dilution
Zn2+
-
concentration of 0.4 mM: activity reaches 142%
additional information
-