Activating Compound | Comment | Organism | Structure |
---|---|---|---|
taurocholate | concentrations of 0.05 M and 0.1 M cause 140% and 160% of activity | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | diagosis of Tay-Sachs disease | Homo sapiens |
General Stability | Organism |
---|---|
resistant to mechanical inactivation by homogenization or freezing and thawing | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Hg2+ | with 0.75 M 6% of activity remains | Homo sapiens | |
N-acetyl-D-galactosamine | - |
Homo sapiens | |
N-acetyl-D-glucosamine | with 0.75 M 34% of activity remains | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.8 | - |
4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-beta-D-hexosaminides + H2O | Homo sapiens | - |
N-acetyl-D-hexosamines | - |
? |
Organic Solvent | Comment | Organism |
---|---|---|
dimethyl sulfoxide | with 7.5% 14% of activity remains | Homo sapiens |
dimethylformamide | with 7.5% 9% of activity remains | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
granulocyte | - |
Homo sapiens | - |
leukocyte | - |
Homo sapiens | - |
mononuclear cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0012 | 0.0025 | substrate: 4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate + H2O | - |
Homo sapiens | 4-methylumbelliferone + 2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate | - |
? | |
N-acetyl-beta-D-hexosaminides + H2O | - |
Homo sapiens | N-acetyl-D-hexosamines | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
- |
37 | stable up to 24 h | Homo sapiens |
50 | - |
rapid inactivation, retarded by acidification | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
3.5 | 4 | substrate: 4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate | Homo sapiens |