Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.52 extracted from

  • Ho, C.W.; Popat, S.D.; Liu, T.W.; Tsai, K.C.; Ho, M.J.; Chen, W.H.; Yang, A.S.; Lin, C.H.
    Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors (2010), Chem. Biol., 5, 489-497.
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme is a target for GlcNAc-inspired iminocyclitiols drug development Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-acetamido-1,2,5-trideoxy-1,5-imino-D-glucitol
-
Homo sapiens
additional information synthesis and development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors, inhibitor enzyme interactions and binding structures, overview Homo sapiens
N-((3S,4R,5S)-1-(7-(bis(4-methoxybenzyl)amino)heptyl)-4,5-dihydroxy-5-(hydroxymethyl)piperidin-3-yl)acetamide
-
Homo sapiens
N-((3S,4R,5S)-4,5-dihydroxy-5-(hydroxymethyl)-1-(7-(4-methoxybenzylamino)heptyl)piperidin-3-yl)acetamide
-
Homo sapiens
N-(7-((3S,4R,5S)-5-acetamido-3,4-dihydroxy-3-(hydroxymethyl)piperidin-1-yl)heptyl)-5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
-
Homo sapiens
N-[1(7-amino-heptyl)]-2-acetamido-1,2,5-trideoxy-1,5-imino-D-glucitol competitive inhibitor Homo sapiens
N-[1(7-azido-heptyl)]-2-acetamido-1,2,5-trideoxy-1,5-imino-D-glucitol
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozyme Hex B
-

Source Tissue

Source Tissue Comment Organism Textmining
chondrocyte
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
Hex
-
Homo sapiens
N-acetyl-beta-hexosaminidase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.25
-
assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000069
-
N-((3S,4R,5S)-1-(7-(bis(4-methoxybenzyl)amino)heptyl)-4,5-dihydroxy-5-(hydroxymethyl)piperidin-3-yl)acetamide pH 4.25, 30°C, isozyme Hex B Homo sapiens
0.0000012
-
N-((3S,4R,5S)-4,5-dihydroxy-5-(hydroxymethyl)-1-(7-(4-methoxybenzylamino)heptyl)piperidin-3-yl)acetamide pH 4.25, 30°C, isozyme Hex B Homo sapiens
0.0000021
-
N-[1(7-amino-heptyl)]-2-acetamido-1,2,5-trideoxy-1,5-imino-D-glucitol pH 4.25, 30°C, isozyme Hex B Homo sapiens
0.0000267
-
N-(7-((3S,4R,5S)-5-acetamido-3,4-dihydroxy-3-(hydroxymethyl)piperidin-1-yl)heptyl)-5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide pH 4.25, 30°C, isozyme Hex B Homo sapiens
0.00054
-
2-acetamido-1,2,5-trideoxy-1,5-imino-D-glucitol pH 4.25, 30°C, isozyme Hex B Homo sapiens
0.0017
-
N-[1(7-azido-heptyl)]-2-acetamido-1,2,5-trideoxy-1,5-imino-D-glucitol pH 4.25, 30°C, isozyme Hex B Homo sapiens

General Information

General Information Comment Organism
malfunction Hex is linked to osteoarthritis and lysosomal storage disorders Homo sapiens
physiological function Hex is the predominant glycosidase released by chondrocytes to degrade glycosaminoglycan Homo sapiens