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3.1.16.1: spleen exonuclease

This is an abbreviated version!
For detailed information about spleen exonuclease, go to the full flat file.

Word Map on EC 3.1.16.1

Reaction

exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 3'-phosphates =

Synonyms

3'-5' exonuclease, 3'-exonuclease, 3'-nucleotide phosphodiesterase, 5' -> 3' exonuclease Xrn2, 5' 3'-exonuclease, 5'-to-3' exonuclease, 5->3 exoribonuclease, Ape2, beef spleen exonuclease, BSEase, BSP, EC 3.1.4.18, exonuclease, FEN-1, flap endonuclease-1, More, NPP1, nucleotide pyrophosphatase/phosphodiesterase 1, phosphodiesterase II, spleen phosphodiesterase, Trm2p, XRNA, XRNB, XRNC, XRND

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.16 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
                3.1.16.1 spleen exonuclease

Inhibitors

Inhibitors on EC 3.1.16.1 - spleen exonuclease

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5'-Terminal phosphate
-
in tRNA
-
acetylation
-
complete inhibition by acetylation of the 2'-OH of tRNA
-
Ap4A
-
-
arsenite
-
weak inhibitor with RNA core as substrate
ATPgammaS
-
-
Deoxyribonucleoside 3'-phosphates
-
-
dihydrouridine
-
in tRNA
dimethyl sulfate
-
inhibition after methylation of 2'-deoxyribooligonucleotides with dimethyl sulfate
F-
-
weak inhibitor with RNA core as substrate
glycosylation
-
no activity with glycosylated oligonucleotides obtained from T4 phage DNA
-
heparin
-
-
Hg2+
-
with RNA core as substrate
high ionic strength
-
KCl
FEN-1 retains up to approximately 70.0% of its endonuclease at 0-50.0 mM, between 75 and 100 mM FEN-1 displays a significant reduction in activity and at the highest salt concentrations between 125-200 mM almost a complete ablation of activity occurres
Mn2+
-
with RNA core as substrate
p-nitrophenyl-TMP
-
-
Pentamidine
-
endo-exonuclease inhibitor, inhibits DNase activity of CBP-Trm2p
pyridoxal 5'phosphate-6-azophenyl-2',4'-disulfonic acid
-
-
ribo- and deoxyribonucleotides
-
with 5'-phosphomonoester group
-
RNAi
-
down-regulation of expression by tetracycline-inducible RNA interference
-
RP-dATPalphaS
-
-
single-stranded DNA-binding protein
-
i.e. StoSSB, from the hyperthermophilic archaeon Sulfolobus tokodaii, StoSSB inhibits the exonuclease activity of StoNurA on ssDNA and dsDNA
-
SP-ATPalphaS
-
-
SP-CTPalphaS
-
-
SP-dATPalphaS
-
-
UDP-glucose
-
-
Zn2+
-
with RNA core as substrate
additional information
-
no inhibition up to 40 mM by lysophosphatidylcholine
-