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3.1.16.1: spleen exonuclease

This is an abbreviated version!
For detailed information about spleen exonuclease, go to the full flat file.

Word Map on EC 3.1.16.1

Reaction

exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 3'-phosphates =

Synonyms

3'-5' exonuclease, 3'-exonuclease, 3'-nucleotide phosphodiesterase, 5' -> 3' exonuclease Xrn2, 5' 3'-exonuclease, 5'-to-3' exonuclease, 5->3 exoribonuclease, Ape2, beef spleen exonuclease, BSEase, BSP, EC 3.1.4.18, exonuclease, FEN-1, flap endonuclease-1, More, NPP1, nucleotide pyrophosphatase/phosphodiesterase 1, phosphodiesterase II, spleen phosphodiesterase, Trm2p, XRNA, XRNB, XRNC, XRND

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.16 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
                3.1.16.1 spleen exonuclease

Disease

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Disease on EC 3.1.16.1 - spleen exonuclease

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Chondrocalcinosis
Inhibition of nucleotide pyrophosphatase/phosphodiesterase 1: implications for developing a calcium pyrophosphate deposition disease modifying drug.
Genetic Diseases, Inborn
Human FEN-1 can process the 5'-flap DNA of CTG/CAG triplet repeat derived from human genetic diseases by length and sequence dependent manner.
Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.
Herpes Simplex
Picornavirus internal ribosome entry site elements target RNA cleavage events induced by the herpes simplex virus virion host shutoff protein.
Huntington Disease
Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instability.
Infections
A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability.
Leukemia
Down-regulation of human FEN-1 gene expression during differentiation of promyelocytic leukemia cells.
Gene expression of flap endonuclease-1 during cell proliferation and differentiation.
Melanoma
Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF.
Neoplasms
Cloning of the Flap Endonuclease-1 Gene in Bombyx mori and Identification of an Antiapoptotic Function.
Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score.
Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.
Neuroblastoma
Role of phosphodiesterase II in cross talk between cGMP and cAMP in human neuroblastoma NB-OK-1 cells.
Ovarian Neoplasms
Immunohistochemical characterization of a monoclonal antibody detecting an endometrioid ovarian cancer-associated antigen.
Prostatic Neoplasms
Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score.
Sarcoma
Nucleases and adenosine 3',5'-cyclic monophosphate phosphodiesterase activities in murine sarcoma virus (Moloney)-infected mice.
Virus Diseases
Nucleases and adenosine 3',5'-cyclic monophosphate phosphodiesterase activities in murine sarcoma virus (Moloney)-infected mice.
Werner Syndrome
Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks.
Stimulation of flap endonuclease-1 by the Bloom's syndrome protein.
Xeroderma Pigmentosum
The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21.