Literature summary for 3.1.16.1 extracted from

Wojcik, M.; Cieslak, M.; Stec, W.J.; Goding, J.W.; Koziolkiewicz, M.
Nucleotide pyrophosphatase/phosphodiesterase 1 is responsible for degradation of antisense phosphorothioate oligonucleotides (2007), Oligonucleotides, 17, 134-145.

Search for more literature for 3.1.16.1

Inhibitors

Inhibitors	Comment	Organism	Structure
Ap4A	-	Homo sapiens
ATP	-	Homo sapiens
ATPgammaS	-	Homo sapiens
heparin	-	Homo sapiens
additional information	no inhibition up to 40 mM by lysophosphatidylcholine	Homo sapiens
p-nitrophenyl-TMP	-	Homo sapiens
pyridoxal 5'phosphate-6-azophenyl-2',4'-disulfonic acid	-	Homo sapiens
RP-dATPalphaS	-	Homo sapiens
SP-ATPalphaS	-	Homo sapiens
SP-CTPalphaS	-	Homo sapiens
SP-dATPalphaS	-	Homo sapiens
UDP-glucose	-	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.016	-	[S]-d[T12]	-	Homo sapiens
0.0715	-	[S]-d[A12]	-	Homo sapiens
0.173	-	[RP-PS]-d[T12]	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
plasma	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	[RP-but last one-PS]-d[T12] is not hydrolyzed	Homo sapiens	?	-	?
[PO/Mix-PS]-d[TPOCPOTPOTPOTPOTPOTPSC] + H2O	21% degraded after 2 hours, 35% degraded after 8 hours	Homo sapiens	?	-	?
[PO/Mix-PS]-d[TPOTPOTPOTPOTPOTPOTPOTPOTPOTPOTPST] + H2O	35% degraded after 2 hours, 75% degraded after 8 hours	Homo sapiens	?	-	?
[PO/RP-PS]-d[TPOCPOTPOTPOTPOTPOTPSC] + H2O	22% degraded after 2 hours, 45% degraded after 8 hours	Homo sapiens	?	-	?
[PO/SP-PS]-d[TPOCPOTPOTPOTPOTPOTPSC] + H2O	20% degraded after 2 hours, 25% degraded after 8 hours	Homo sapiens	?	-	?
[PS]-d[A6] + H2O	-	Homo sapiens	?	-	?
[RP-PS]-d[A12] + H2O	-	Homo sapiens	?	-	?
[RP-PS]-d[T12] + H2O	25% degraded after 2 hours, 75% degraded after 8 hours	Homo sapiens	?	-	?
[S]-d[A12] + H2O	-	Homo sapiens	?	-	?
[S]-d[T12] + H2O	100% degraded after 2 hours	Homo sapiens	?	-	?
[S]-d[TCCTCTTTTTTT] + H2O	-	Homo sapiens	?	-	?
[S]-d[TCTTTTTC] + H2O	100% degraded after 2 hours	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
3'-exonuclease	-	Homo sapiens
More	EC3.1.4.1/EC 3.6.1.9	Homo sapiens
NPP1	-	Homo sapiens
nucleotide pyrophosphatase/phosphodiesterase 1	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0002	-	inhibition of degradation of [RP-PS]-d[A12]	Homo sapiens	SP-ATPalphaS
0.0014	-	inhibition of degradation of [PO]-d[TCCTCTTTTTTT]	Homo sapiens	SP-ATPalphaS
0.0015	-	inhibition of degradation of [PO]-d[TCCTCTTTTTTT]	Homo sapiens	SP-dATPalphaS
0.002	-	inhibition of degradation of [PO]-d[A12]	Homo sapiens	SP-ATPalphaS
0.002	-	inhibition of degradation of [RP-PS]-d[A12]	Homo sapiens	RP-dATPalphaS
0.005	-	inhibition of degradation of [PO]-d[A12]	Homo sapiens	RP-dATPalphaS
0.005	-	inhibition of degradation of [PO]-d[TCCTCTTTTTTT]	Homo sapiens	RP-dATPalphaS
0.0084	-	inhibition of degradation of [PO]-d[TCCTCTTTTTTT]	Homo sapiens	SP-CTPalphaS
0.027	-	inhibition of degradation of [PO]-d[TCCTCTTTTTTT]	Homo sapiens	ATPgammaS
0.027	-	inhibition of degradation of [PO]-d[TCCTCTTTTTTT]	Homo sapiens	p-nitrophenyl-TMP
0.037	-	inhibition of degradation of [PO]-d[TCCTCTTTTTTT]	Homo sapiens	Ap4A
0.054	-	inhibition of degradation of [PO]-d[TCCTCTTTTTTT]	Homo sapiens	ATP
0.071	-	inhibition of degradation of [PO]-d[TCCTCTTTTTTT]	Homo sapiens	pyridoxal 5'phosphate-6-azophenyl-2',4'-disulfonic acid
0.106	-	inhibition of degradation of [PO]-d[TCCTCTTTTTTT]	Homo sapiens	UDP-glucose

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)