3.1.16.1: spleen exonuclease
This is an abbreviated version!
For detailed information about spleen exonuclease, go to the full flat file.
Word Map on EC 3.1.16.1
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3.1.16.1
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flap
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endonuclease-1
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structure-specific
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okazaki
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nucleases
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micrococcal
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snake
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polynucleotide
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5'-flaps
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32p-postlabeling
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3'-monophosphate
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long-patch
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lagging-strand
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2'-deoxyguanosine
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5'-exonuclease
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exonucleolytic
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dinucleoside
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fen1
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analysis
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internucleotide
- 3.1.16.1
- flap
-
endonuclease-1
-
structure-specific
-
okazaki
- nucleases
-
micrococcal
-
snake
- polynucleotide
-
5'-flaps
-
32p-postlabeling
- 3'-monophosphate
-
long-patch
-
lagging-strand
- 2'-deoxyguanosine
- 5'-exonuclease
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exonucleolytic
-
dinucleoside
- fen1
- analysis
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internucleotide
Reaction
exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 3'-phosphates =
Synonyms
3'-5' exonuclease, 3'-exonuclease, 3'-nucleotide phosphodiesterase, 5' -> 3' exonuclease Xrn2, 5' 3'-exonuclease, 5'-to-3' exonuclease, 5->3 exoribonuclease, Ape2, beef spleen exonuclease, BSEase, BSP, EC 3.1.4.18, exonuclease, FEN-1, flap endonuclease-1, More, NPP1, nucleotide pyrophosphatase/phosphodiesterase 1, phosphodiesterase II, spleen phosphodiesterase, Trm2p, XRNA, XRNB, XRNC, XRND
ECTree
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Application
Application on EC 3.1.16.1 - spleen exonuclease
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analysis
additional information
analysis
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broadly applicable, robust, and rapid method for complete sequence confirmation of highly modified oligonucleotides containing a mixture of 2'-deoxy, 2'-fluoro, 2'-O-methyl, abasic and ribonucleotides. The sense and antisense strands from synthetic short interfering RNA duplexes are digested individually using both 5'- and 3'-exonucleases and the resulting ladders are analyzed using MALDITOF mass spectrometry. Complete sequence confirmation for the antisense strands of four synthetic RNA duplexes is obtained, whereas a three-base sequence gap in the 5'-end is observed for all four sense strands. Outline of a general strategy for routine sequence confirmation of highly modified oligonucleotides
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Ape2 exhibits strong 3'-5' exonuclease and 3'-phosphodiesterase activities and has only a very weak AP-endonuclease activity
additional information
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important role for TRM2 in DNA repair with a potential involvement of its nuclease function in homologous recombination based repair of DNA double-strand breaks, plays no role in the nucleotide excision repair and/or base excision repair pathways
additional information
Plasmodium FEN-1s have enzymatic activities similar to other species but contain extended C-termini and a more internally located proliferating cell nuclear antigen-binding site. FEN-1 homologs exhibit both endonuclease and exonuclease activities in vitro
additional information
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Plasmodium FEN-1s have enzymatic activities similar to other species but contain extended C-termini and a more internally located proliferating cell nuclear antigen-binding site. FEN-1 homologs exhibit both endonuclease and exonuclease activities in vitro
additional information
Plasmodium FEN-1s have enzymatic activities similar to other species but contain extended C-termini and a more internally located proliferating cell nuclear antigen-binding site. FEN-1 homologs exhibit both endonuclease and exonuclease activities in vitro
additional information
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Plasmodium FEN-1s have enzymatic activities similar to other species but contain extended C-termini and a more internally located proliferating cell nuclear antigen-binding site. FEN-1 homologs exhibit both endonuclease and exonuclease activities in vitro
additional information
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XRNA and XRND are required for trypanosome growth
additional information
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Plasmodium FEN-1s have enzymatic activities similar to other species but contain extended C-termini and a more internally located proliferating cell nuclear antigen-binding site. FEN-1 homologs exhibit both endonuclease and exonuclease activities in vitro
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