Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.1.13.4: poly(A)-specific ribonuclease

This is an abbreviated version!
For detailed information about poly(A)-specific ribonuclease, go to the full flat file.

Word Map on EC 3.1.13.4

Reaction

exonucleolytic cleavage of poly(A) to 5'-AMP =

Synonyms

2',3'-exoribonuclease, 3'-exoribonuclease, adenosine-specific exonuclease, AHG2, AtPARN, BTG1-binding factor 1, Caf1, CCR4, CCR4 deadenylase complex, CCR4-associated factor 1, Ccr4-Not complex, CCR4-NOT transcription complex subunit 7, Ccr4p/Pop2p/Notp complex, CNOT6L nuclease, cytoplasmic deadenylase, deadenylase, hPAN, HsPNLDC1, MMAR_3223, More, nuclease, polyadenylate-specific exoribo-, PAB1P-dependent poly(A)-nuclease, PAN, PAN2, PAN3, PARN, PARN-1, PARN-like domain-containing protein 1, PF2046, PNLDC1, poly(A) nuclease, poly(A) nuclease complex, poly(A) ribonuclease, poly(A)-selective ribonuclease, poly(A)-specific 3'-5' ribonuclease, poly(A)-specific 3'-exoribonuclease, poly(A)-specific mRNA exoribonuclease, poly(A)-specific ribonuclease, poly(A)-specific RNase, Pop2p deadenylase, RNase AS, RNase H

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.13 Exoribonucleases producing 5′-phosphomonoesters
                3.1.13.4 poly(A)-specific ribonuclease

Molecular Weight

Molecular Weight on EC 3.1.13.4 - poly(A)-specific ribonuclease

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
135007
x * 135007, catalytic subunit hPAN2, + x * 75886, regulatory subunit hPAN3, calculated from amino acid sequence
152400
recombinant His-tagged enzyme
161000
17000
2 * 17000, SDS-PAGE, dimerization of enzyme fragment PARN(443-560)
180000 - 220000
-
gel filtration
18500
2 * 18500, calculated
290000
gel filtration, full length enzyme
31000
-
1 * 58000, 1 * 31000, SDS-PAGE
37000
dimerization of enzyme fragment PARN(443-560), gel filtration
38460
gel filtration coupled with multiangle light scattering
45000
-
x * 45000, recombinant CNOT6L nuclease domain, SDS-PAGE
46000
-
truncated form completely missing the RRM
54000
58000
-
1 * 58000, 1 * 31000, SDS-PAGE
62000
-
PARN (p62), residues 1-540
62000 - 74000
-
-
73500
amino acid analysis
74000
75886
x * 135007, catalytic subunit hPAN2, + x * 75886, regulatory subunit hPAN3, calculated from amino acid sequence
76200
x * 76200, His-tagged full-length enzyme, SDS-PAGE
80000
-
gel filtration