3.1.13.4: poly(A)-specific ribonuclease

This is an abbreviated version!
For detailed information about poly(A)-specific ribonuclease, go to the full flat file.

Word Map on EC 3.1.13.4

3.1.13.4

deadenylation

polya-specific

rna-binding

decapping

polyadenylation

polya-binding

nocturnin

au-rich

mirna-mediated

telomere

trim

argonaute

eif4e

pirnas

pumilio

tristetraprolin

cap-binding

congenita

exonucleolytic

p-bodies

dyskeratosis

oligoadenylation

pabps

diagnostics

miriscs

poly-a

are-binding

microrna-mediated

medicine

eif4e-binding

Reaction

exonucleolytic cleavage of poly(A) to 5'-AMP =

Synonyms

2',3'-exoribonuclease, 3'-exoribonuclease, adenosine-specific exonuclease, AHG2, AtPARN, BTG1-binding factor 1, Caf1, CCR4, CCR4 deadenylase complex, CCR4-associated factor 1, Ccr4-Not complex, CCR4-NOT transcription complex subunit 7, Ccr4p/Pop2p/Notp complex, CNOT6L nuclease, cytoplasmic deadenylase, deadenylase, hPAN, HsPNLDC1, MMAR_3223, More, nuclease, polyadenylate-specific exoribo-, PAB1P-dependent poly(A)-nuclease, PAN, PAN2, PAN3, PARN, PARN-1, PARN-like domain-containing protein 1, PF2046, PNLDC1, poly(A) nuclease, poly(A) nuclease complex, poly(A) ribonuclease, poly(A)-selective ribonuclease, poly(A)-specific 3'-5' ribonuclease, poly(A)-specific 3'-exoribonuclease, poly(A)-specific mRNA exoribonuclease, poly(A)-specific ribonuclease, poly(A)-specific RNase, Pop2p deadenylase, RNase AS, RNase H

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.13 Exoribonucleases producing 5′-phosphomonoesters

3.1.13.4 poly(A)-specific ribonuclease

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Results	in table
14	Activating Compound
13254	AA Sequence
6	Application
2	CAS Registry Number
38	Cloned(Commentary)
7	Crystallization (Commentary)
243	Disease/ Diagnostics
3	Expression
44	General Information
3	General Stability
35	IC50 Value
84	Inhibitors
17	Ki Value [mM]
9	KM Value [mM]
31	Localization
64	Metals/Ions
34	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
91	Organism
54	PDB ID
14	pH Optimum
1	pH Range
2	Posttranslational Modification
69	Protein Variants
37	Purification (Commentary)
3	Reaction
3	Reaction Type
81	Reference
53	Source Tissue
13	Specific Activity [micromol/min/mg]
4	Storage Stability
107	Substrates and Products (Substrate)
21	Subunits
114	Synonyms
11	Temperature Optimum [°C]
5	Temperature Stability [°C]
5	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.1.13.4 - poly(A)-specific ribonuclease

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3'untranslated regions of RNA

Saccharomyces cerevisiae

regulates RNase acitvity

134095

CH3COOK

2 entries

K+

Homo sapiens

allosteric activator of PARN and its truncated forms, optimal concentration is around 100 mM, with the increase of the K+ concentration, the enzyme reaches its Vmax at a much lower substrate concentration

690777

Pan2 protein

Saccharomyces cerevisiae

required for poly(A)-binding in poly(A) cleavage

134094

poly(A)-binding protein PAB 1

Saccharomyces cerevisiae

PAB 1 required

134093

polyadenylate-binding protein

Homo sapiens

Q504Q3

or spermidine, required for activity of hPAN complex, cannot stimulate hPAN2 alone

spermidine

tristetraprolin

required for degradation of polyadenylated RNA containing AU-rich elements

653219

additional information

5 entries