Activating Compound | Comment | Organism | Structure |
---|---|---|---|
polyadenylate-binding protein | or spermidine, required for activity of hPAN complex, cannot stimulate hPAN2 alone | Homo sapiens | |
spermidine | or polyadenylate-binding protein, required for activity of hPAN2 and of hPAN complex | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Poly(A) | strong inhibition of both spermidine- and polyadenylate-binding protein-activated hPAN complex | Homo sapiens | |
poly(C) | strong inhibition of spermidine-, slight inhibition of polyadenylate-binding protein-activated hPAN complex | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
75886 | - |
x * 135007, catalytic subunit hPAN2, + x * 75886, regulatory subunit hPAN3, calculated from amino acid sequence | Homo sapiens |
135007 | - |
x * 135007, catalytic subunit hPAN2, + x * 75886, regulatory subunit hPAN3, calculated from amino acid sequence | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q504Q3 | catalytic subunit hPAN2, regulatory subunit hPAN3: Q76E13; catalytic subunit hPAN2, regulatory subunit hPAN3 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
poly(A)-mRNA + H2O | - |
Homo sapiens | 5'-AMP | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 135007, catalytic subunit hPAN2, + x * 75886, regulatory subunit hPAN3, calculated from amino acid sequence | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
hPAN | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00007 | - |
Poly(A) | 37°C, pH 7.5, spermidine-activated hPAN | Homo sapiens | |
0.002 | - |
poly(C) | 37°C, pH 7.5, spermidine-activated hPAN | Homo sapiens |