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Literature summary for 3.1.13.4 extracted from

  • Uchida, N.; Hoshino, S.i.; Katada, T.
    Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein (2004), J. Biol. Chem., 279, 1383-1391.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
polyadenylate-binding protein or spermidine, required for activity of hPAN complex, cannot stimulate hPAN2 alone Homo sapiens
spermidine or polyadenylate-binding protein, required for activity of hPAN2 and of hPAN complex Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Poly(A) strong inhibition of both spermidine- and polyadenylate-binding protein-activated hPAN complex Homo sapiens
poly(C) strong inhibition of spermidine-, slight inhibition of polyadenylate-binding protein-activated hPAN complex Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
75886
-
x * 135007, catalytic subunit hPAN2, + x * 75886, regulatory subunit hPAN3, calculated from amino acid sequence Homo sapiens
135007
-
x * 135007, catalytic subunit hPAN2, + x * 75886, regulatory subunit hPAN3, calculated from amino acid sequence Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q504Q3 catalytic subunit hPAN2, regulatory subunit hPAN3: Q76E13; catalytic subunit hPAN2, regulatory subunit hPAN3
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
poly(A)-mRNA + H2O
-
Homo sapiens 5'-AMP
-
?

Subunits

Subunits Comment Organism
? x * 135007, catalytic subunit hPAN2, + x * 75886, regulatory subunit hPAN3, calculated from amino acid sequence Homo sapiens

Synonyms

Synonyms Comment Organism
hPAN
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00007
-
Poly(A) 37°C, pH 7.5, spermidine-activated hPAN Homo sapiens
0.002
-
poly(C) 37°C, pH 7.5, spermidine-activated hPAN Homo sapiens