3.1.13.4: poly(A)-specific ribonuclease

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For detailed information about poly(A)-specific ribonuclease, go to the full flat file.

Reaction

exonucleolytic cleavage of poly(A) to 5'-AMP =

Synonyms

2',3'-exoribonuclease, 3'-exoribonuclease, adenosine-specific exonuclease, AHG2, AtPARN, BTG1-binding factor 1, Caf1, CCR4, CCR4 deadenylase complex, CCR4-associated factor 1, Ccr4-Not complex, CCR4-NOT transcription complex subunit 7, Ccr4p/Pop2p/Notp complex, CNOT6L nuclease, cytoplasmic deadenylase, deadenylase, hPAN, HsPNLDC1, MMAR_3223, More, nuclease, polyadenylate-specific exoribo-, PAB1P-dependent poly(A)-nuclease, PAN, PAN2, PAN3, PARN, PARN-1, PARN-like domain-containing protein 1, PF2046, PNLDC1, poly(A) nuclease, poly(A) nuclease complex, poly(A) ribonuclease, poly(A)-selective ribonuclease, poly(A)-specific 3'-5' ribonuclease, poly(A)-specific 3'-exoribonuclease, poly(A)-specific mRNA exoribonuclease, poly(A)-specific ribonuclease, poly(A)-specific RNase, Pop2p deadenylase, RNase AS, RNase H

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.13 Exoribonucleases producing 5′-phosphomonoesters

                3.1.13.4 poly(A)-specific ribonuclease

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Results	in table
14	Activating Compound
13254	AA Sequence
6	Application
2	CAS Registry Number
38	Cloned(Commentary)
7	Crystallization (Commentary)
243	Disease/ Diagnostics
3	Expression
44	General Information
3	General Stability
35	IC50 Value
84	Inhibitors
17	Ki Value [mM]
9	KM Value [mM]
31	Localization
64	Metals/Ions
34	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
91	Organism
54	PDB ID
14	pH Optimum
1	pH Range
2	Posttranslational Modification
69	Protein Variants
37	Purification (Commentary)
3	Reaction
3	Reaction Type
81	Reference
53	Source Tissue
13	Specific Activity [micromol/min/mg]
4	Storage Stability
107	Substrates and Products (Substrate)
21	Subunits
114	Synonyms
11	Temperature Optimum [°C]
5	Temperature Stability [°C]
5	Turnover Number [1/s]

Expression

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Expression on EC 3.1.13.4 - poly(A)-specific ribonuclease

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

nocturin deadenylase shows rhythmic expression under circadian control. It is rapidly induced in response to serum shock, LPS and other stimuli

Mus musculus

O35710, Q8VDG3

756072

nocturnin is rhythmically expressed in the cytoplasm of the retinal retina photoreceptor cells, with peak mRNA levels in the early night

Xenopus laevis

P79942, Q90ZA1

756528

the expression of several deadenylases is altered in squamous cell lung cancer, SCC. Quantitative real-time PCR shows that four deadenylases, PARN, CNOT6, CNOT7 and NOC, are differentially expressed in SCC clinical samples. PARN overexpression correlates with younger patient age and CNOT6 overexpression with non-metastatic tumors. Kaplan-Meier analysis suggests that increased levels of PARN and NOC correlate with significantly increased survival. The gene expression deregulation is functionally enriched for gene ontologies related to cell adhesion, cell junction, muscle contraction and metabolism

Homo sapiens

O95453

751545