1.14.14.18: heme oxygenase (biliverdin-producing)
This is an abbreviated version!
For detailed information about heme oxygenase (biliverdin-producing), go to the full flat file.
Word Map on EC 1.14.14.18
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1.14.14.18
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monoxide
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cytoprotective
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endothelial
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necrosis
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dismutase
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protoporphyrin
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erythroid
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2-related
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tnf
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bilirubin
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artery
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malondialdehyde
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lipopolysaccharide
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catalase
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hemin
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neuroprotective
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ischemia
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gsh
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lps
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sod
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anti-oxidant
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mapks
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sirna
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caspase-3
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quinone
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pulmonary
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reperfusion
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lps-induced
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hypoxia
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cyclooxygenase-2
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cox-2
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ferritin
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erk
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nf-e2-related
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anti-apoptotic
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cobalt
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myeloperoxidase
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ischemia-reperfusion
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nrf2-mediated
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pro-oxidant
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kelch-like
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nadph:quinone
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factor-2
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lps-stimulated
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2-like
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erythroid-derived
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oxygenases
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delta-aminolevulinic
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sulforaphane
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hyperbilirubinemia
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medicine
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drug development
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analysis
- 1.14.14.18
- monoxide
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cytoprotective
- endothelial
- necrosis
- dismutase
- protoporphyrin
-
erythroid
-
2-related
- tnf
- bilirubin
- artery
- malondialdehyde
- lipopolysaccharide
- catalase
- hemin
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neuroprotective
- ischemia
- gsh
- lps
- sod
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anti-oxidant
- mapks
- sirna
- caspase-3
- quinone
- pulmonary
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reperfusion
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lps-induced
- hypoxia
- cyclooxygenase-2
- cox-2
- ferritin
- erk
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nf-e2-related
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anti-apoptotic
- cobalt
- myeloperoxidase
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ischemia-reperfusion
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nrf2-mediated
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pro-oxidant
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kelch-like
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nadph:quinone
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factor-2
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lps-stimulated
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2-like
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erythroid-derived
- oxygenases
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delta-aminolevulinic
- sulforaphane
- hyperbilirubinemia
- medicine
- drug development
- analysis
Reaction
Synonyms
biliverdin-producing heme oxygenase, ChuS, ChuZ, EC 1.14.99.3, haem oxygenase, heme oxygenase, heme oxygenase 1, heme oxygenase 2, heme oxygenase-1, heme oxygenase-2, HemO, Hmox1, Hmox1a, Hmox1b, Hmox2, Hmox2a, Hmox2b, HmuO, Hmx1, HO, HO-1, HO-2, Ho1, Ho2, Ho3, HO4, HSP32, HugZ, HY1, inducible heme oxygenase-1, More, MsHO1, ORP33 proteins, oxygenase, heme (decyclizing), pbsA1, PigA, proteins, specific or class, ORP33 (oxygen-regulated protein 33,000-mol.-wt.), Syn HO-1, Syn HO-2
ECTree
1.14.14.18 heme oxygenase (biliverdin-producing)Advanced search results
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results (Activating Compound
Activating Compound on EC 1.14.14.18 - heme oxygenase (biliverdin-producing)
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
2,4,6-Trinitrobenzene sulfonic acid
induces HO-1 expression in the colon and stimulates its catalytic activity
5-aminosalicylic acid
induces HO-1 expression in the colon and stimulates its catalytic activity
ascorbate
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addition of a second electron donor like ascorbate leads to 10times faster heme conversion
brazilin
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main constituent of Caesalpinia sappan, induces HO-1 expression in a concentration-dependent manner at 0.01-0.3 mM at the level of protein synthesis, thus without affecting mRNA transcription of HO-1
Calmodulin
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calcium-dependent binding to enzyme, 3fold increase in catalytic activity
Fe/S cluster
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heme oxygenase consists of 3 required protein components: a ferredoxin-like Fe-S cluster protein that can be replaced by ferredoxin, a protein that is inactivated by diethyldicarbonate, inactivation is blocked by heme, a protein with ferredoxin-linked cytochrome c reductase activity
lipopolysaccharide
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activates the enzyme, activation is partly reduced by addition of inhibitor Sn-protoporphyrin
propionate
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the enzyme requires only a single propionate interacting with the buried terminus of Lys16 to exhibit full activity, and it tolerates the existence of a propionate at the exposed 8-position
SnCl2
is a potent and specific inducer of renal HO-1 expression and activity
additional information
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heme turnover is promoted by light when spinach thylakoids are present
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additional information
HO-1 is induced by epibatidine via neuronal nicotinic acetylcholine receptors and ERK1/2 in the neuroprotective signaling cascade, overview
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additional information
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HO-1 is induced by epibatidine via neuronal nicotinic acetylcholine receptors and ERK1/2 in the neuroprotective signaling cascade, overview
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additional information
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triphlorethol-A, i.e. 2-[2-(3,5-dihydroxyphenoxy)-3,5-dihydroxyphenoxy]benzene-1,3,5-triol, a phlorotannin isolated from Ecklonia cava, induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor, triphlorethol-A increases nuclear translocation, ARE, binding, and transcriptional activity of Nrf2, transcription factor Nrf2 regulates antioxidant response element, ARE, of phase 2 detoxifying and antioxidant enzymes, requirement for ERK activation in the induction of HO-1 expression by triphlorethol-A because an ERK inhibitor significantly reduces HO-1 protein expression in response to triphlorethol-A, overview
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additional information
enzyme activity is increased by 7.5 and 15 kJ/squaremeter UV-B doses
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additional information
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enzyme activity is increased by 7.5 and 15 kJ/squaremeter UV-B doses
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additional information
capsaicin, i.e. trans-8-methyl-N-vanillyl-6-nonenamide, induces heme oxygenase-1 expression in Hep-G2 cells via activation of PI3K-Nrf2 signaling
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additional information
curcumin, but not its metabolite tetrahydrocurcumin, induces HO-1 expression and growth inhibition of aortic smooth muscle cells through Nrf2-dependent antioxidant response element, ARE, activation, mechanism, overview, curcumin is isolated from the rhizomes of turmeric
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additional information
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curcumin, but not its metabolite tetrahydrocurcumin, induces HO-1 expression and growth inhibition of aortic smooth muscle cells through Nrf2-dependent antioxidant response element, ARE, activation, mechanism, overview, curcumin is isolated from the rhizomes of turmeric
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additional information
dehydrocostus lactone induces HO-1 expression in Hep-G2 cells, while mokko lactone, a reduced product of dehydrocostus lactone, and alpha-methyl-gamma-butyrolactone, a parent structure of mokko lactone, do not induce HO-1 expression
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additional information
epigallocatechin activates heme oxygenase-1 expression via protein kinase Cdelta, not PKCalpha and PKCbeta, and Nrf2, siRNA knock down of Nrf2 significantly inhibits EGC-induced HO-1 expression, inhibition of PKCdelta, e.g. by Ro-31-8220, decreases EGC-induced HO-1 mRNA expression, whereas MAP kinase and phosphatidylinositol-3-kinase pathway inhibitors have no significant effect, overview
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additional information
exogenous CO activates Nrf2 through the phosphorylation of protein kinase R-like endoplasmic reticulum kinase, PERK, resulting in HO-1 expression
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additional information
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exogenous CO activates Nrf2 through the phosphorylation of protein kinase R-like endoplasmic reticulum kinase, PERK, resulting in HO-1 expression
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additional information
far infrared irradiation induces HO-1 protein, mRNA and promoter activity through heat stress which activates the antioxidant responsive element/NF-E2-related factor-2 complex, overview
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additional information
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far infrared irradiation induces HO-1 protein, mRNA and promoter activity through heat stress which activates the antioxidant responsive element/NF-E2-related factor-2 complex, overview
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additional information
ferric protoporphyrin IX enhances the HO-1 expression in MCF-7 cells
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additional information
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ferric protoporphyrin IX enhances the HO-1 expression in MCF-7 cells
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additional information
hemin and taurine chloramine, Tau-Cl, raise the transcription of the gene encoding HO-1
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additional information
hemin induces heme oxygenase-1 expression in human umbilical vein endothelial cells
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additional information
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hemin induces heme oxygenase-1 expression in human umbilical vein endothelial cells
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additional information
HO-1 expression, prooxidative activity, and cytotoxicity are increased after treatment with heme, heavy metals, and peroxides compared to control cells
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additional information
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HO-1 expression, prooxidative activity, and cytotoxicity are increased after treatment with heme, heavy metals, and peroxides compared to control cells
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additional information
HO-1 is induced by NO in macrophages and hepatocytes inhibiting apoptotic cell death of hepatocytes via the regulation of cellular homeostasis of prooxidant iron
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additional information
HO-1 is strongly induced in the skin after long wave ultraviolet radiation, UVA-1 irradiation generates oxidized phospholipids derived from 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine that mediate the expression of HO-1 in skin cells, epoxyisoprostanephosphatidylcholine also induces the enzyme in the skin, overview
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additional information
induction of HO-1 by hemin and Zn2+-protoporphyrin IX in presence or absence of light, Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins, overview
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additional information
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induction of HO-1 by hemin and Zn2+-protoporphyrin IX in presence or absence of light, Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins, overview
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additional information
oxidative stress and arsenite strongly induce HMOX1, heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1, BACH1 repression is dominant over NRF2-mediated HMOX1 transcription and inactivation of BACH1 is a prerequisite for HMOX1 induction, but nuclear accumulation of NRF2 is not necessary for HMOX1 induction
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additional information
oxidized-1-palmitoyl-2-arachidonoyl-sn-glycerol-3-phosphocholine, i.e. Ox-PAPC, induces HO-1 involving Nrf2 activation, the transcriptional activation is regulated by the plasma membrane electron transport complex, PMET, containing ecto-NADH oxidase 1, eNOX1, and NADPH:quinone oxidoreductase 1, NQO1. Chemical inhibitors of PMET system and siRNAs to PMET components NQO1 and eNOX1, as well as exogenous NAD(P)H significantly decrease HO-1 induction by Ox-PAPC
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additional information
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oxidized-1-palmitoyl-2-arachidonoyl-sn-glycerol-3-phosphocholine, i.e. Ox-PAPC, induces HO-1 involving Nrf2 activation, the transcriptional activation is regulated by the plasma membrane electron transport complex, PMET, containing ecto-NADH oxidase 1, eNOX1, and NADPH:quinone oxidoreductase 1, NQO1. Chemical inhibitors of PMET system and siRNAs to PMET components NQO1 and eNOX1, as well as exogenous NAD(P)H significantly decrease HO-1 induction by Ox-PAPC
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additional information
the enzyme expression is induced by enterolactone from enterobacteria through activation of nuclear factor-E2-related factor 2, Nrf2, in endothelial cells
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additional information
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the enzyme expression is induced by enterolactone from enterobacteria through activation of nuclear factor-E2-related factor 2, Nrf2, in endothelial cells
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additional information
the enzyme is induced by 5-aminolevulinic acid, the activation is reduced to 29% by gene silencing with siRNA, overview
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additional information
vitreous induces heme oxygenase-1 expression mediated by transforming growth factor-beta and reactive oxygen species generation in human retinal pigment epithelial cells. Activator protein-1 binding sites are located in the promoter region of HO-1, and TGF-beta also induces the enzyme, while inhibitors of TGF-beta signaling, e.g. SB431542 or TGF-beta-neutralizing antibodies, decrease the vitreous induction of HO-1, but PD98059, an inhibitor of the ERK pathway, has no effect on HO-1 induction, overview
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additional information
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vitreous induces heme oxygenase-1 expression mediated by transforming growth factor-beta and reactive oxygen species generation in human retinal pigment epithelial cells. Activator protein-1 binding sites are located in the promoter region of HO-1, and TGF-beta also induces the enzyme, while inhibitors of TGF-beta signaling, e.g. SB431542 or TGF-beta-neutralizing antibodies, decrease the vitreous induction of HO-1, but PD98059, an inhibitor of the ERK pathway, has no effect on HO-1 induction, overview
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additional information
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a higher dilauroylphosphatidylcholine/HO-1 ratio than typically used provides an improved environment for HO-1 activity
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additional information
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positive correlation between seminal plasma HO enzyme activity and sperm concentration, sperm motility percentage, motile spermatozoa ml-1 and sperm normal morphology per cent
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additional information
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the proximal residue histidine 25 plays a key role in HO-1 activity
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additional information
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gamma-irradition of 0.5 Gy/min dose power causes a significant increase of activity
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additional information
at low concentrations curcumin induces the expression of HO-1 in RAW264.7 macrophages
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additional information
cobalt protoporphyrin, CoPPIX, induces the enzyme, molecular mechanism, overview, CoPPIX inhibits STAT3 phosphorylation and the LPS-mediated maturation of bone marrow-derived dendritic cells independently of HO-1
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additional information
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cobalt protoporphyrin, CoPPIX, induces the enzyme, molecular mechanism, overview, CoPPIX inhibits STAT3 phosphorylation and the LPS-mediated maturation of bone marrow-derived dendritic cells independently of HO-1
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additional information
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hemin is an inducer of HO-1, additive effect of hemin with dexamethasone, overview
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additional information
lipopolysaccharide, from Escherichia coli, serotype 0127:B8, upregulates the expression of HO-1 in adult and fetal mouse liver, maternal LPS exposure results in oxidative stress in fetuses, which may contribute to LPS-induced developmental toxicity, LPS-induced upregulation of HO-1 is blocked by alpha-phenyl-N-t-butylnitrone, PBN, a free radical spin trapping agent, overview
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additional information
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lipopolysaccharide, from Escherichia coli, serotype 0127:B8, upregulates the expression of HO-1 in adult and fetal mouse liver, maternal LPS exposure results in oxidative stress in fetuses, which may contribute to LPS-induced developmental toxicity, LPS-induced upregulation of HO-1 is blocked by alpha-phenyl-N-t-butylnitrone, PBN, a free radical spin trapping agent, overview
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additional information
methoxychalcones, especially 5-methoxychalcone, 3,4,5-trimethoxychalcone, and 3,4,5,3',4',5'-hexamethoxychalcone, induce the enzyme expression and activity in macrophages, overview, increase in heme oxygenase activity and HO-1 protein expression mediated by CH25 is significantly attenuated by the presence of an inhibitor of PI3K LY2940002, as well as by the addition of the glutathione precursor NAC
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additional information
simvastatin induces the enzyme in neurons, HO-1 upregulation is significantly associated with increased nuclear factor kappa B activation, manifested as IkappaBalpha phosphorylation and p65 nuclear translocation, as well as increased production of superoxides, inhibition of the effects by zinc protoporphyrin
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additional information
striatal blood injection increases HO activity, and oxidative stress induces the enzyme, overview
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additional information
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striatal blood injection increases HO activity, and oxidative stress induces the enzyme, overview
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additional information
tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression via intracellular production of reactive oxygen species, and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells. Inhibition of HO-1 or scavenging of CO significantly reverses the inhibition of LPS-stimulated nitrite accumulation by tanshinone IIA, signaling pathways, overview. Activation of PI 3-K and ERK signaling pathways are required for tanshinone-induction of HO-1 protein expression in RAW 264.7 macrophages
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additional information
the HO-1 gene is transcriptionally induced by the phorbol ester PMA in cell cultures of monocytic cells with a regulatory pattern that is different from that of LPS-dependent HO-1 induction in these cells, overview, the upregulation is abrogated in embryonic fibroblasts from p65-/- mice, antioxidant N-acetylcysteine and inhibitors of p38 MAPK or serine/threonine kinase CK2 also block the upregulating effect of PMA, thus induction of HO-1 gene expression by PMA is regulated via an IkappaB kinase-independent, atypical NFkappaB pathway that is mediated via the activation of p38 MAPK and CK2, overview, PMA-dependent HO-1 gene activation requires IkappaBalpha, but notIKK2
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additional information
the PKCdelta/Nrf2/ARE signaling up-regulates heme oxygenase-1
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additional information
the toll-like receptor 2 is involved in HO-1 induction in glial cells, 34fold induction of HO-1 by stab-wound injury in wild-type mice, overview
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additional information
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the toll-like receptor 2 is involved in HO-1 induction in glial cells, 34fold induction of HO-1 by stab-wound injury in wild-type mice, overview
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additional information
tranilast, i.e. N-[3',4'-dimethoxycinnamonyl] anthranilic acid, an orally active anti-allergic drug, tranilast induces heme oxygenase-1 expression through the extracellular signal-regulated kinase-1/2 pathway in RAW264.7 macrophages. Effects of tranilast on LPS-induced PGE2, NO, TNF-alpha, and IL-1beta production are partially reversed by the HO-1 inhibitor tin protoporphyrin, overview. UO126 significantly inhibits tranilast-induced HO-1 expression, but neither SB203580 nor SP600125 have a significant effect on HO-1 expression by tranilast
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additional information
butylated hydroxyanisole stimulates heme oxygenase-1 gene expression after rat carotid artery injury, overview
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additional information
curcumin, but not its metabolite tetrahydrocurcumin, induces HO-1 expression and growth inhibition of vascular smooth muscle cells through Nrf2-dependent antioxidant response element, ARE, activation, mechanism, overview, curcumin is isolated from the rhizomes of turmeric
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additional information
heme oxygenase-1 is induced by tert-butylhydroquinone and by deltamethrin via activation of Nrf2, overview
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additional information
HO-1 is a heat shock protein with anti-inflammatory activity
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additional information
HO-1 is inducible in response to a variety of chemical and physical stress conditions to function as a cytoprotective molecule, hemin and cadmium chloride-mediated HO-1 induction, overview
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additional information
simvastatin induces the enzyme in neurons, HO-1 upregulation is significantly associated with increased nuclear factor kappa B activation, manifested as IkappaBalpha phosphorylation and p65 nuclear translocation, as well as increased production of superoxides, inhibition of the effects by zinc protoporphyrin
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additional information
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the enzyme activity is positively correlated with nitric oxide and cGMP levels in cavernous tissue, overview
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additional information
the HO-1 gene is transcriptionally induced by the phorbol ester PMA, mediated via a newly identified kappaB element of the proximal rat HO-1 gene promoter region, overview
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additional information
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no significant changes in HO-1 mRNA levels between ethanol treated and pair-fed control
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