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Literature summary for 1.14.14.18 extracted from

  • Kim, K.M.; Pae, H.O.; Zhung, M.; Ha, H.Y.; Ha, Y.A.; Chai, K.Y.; Cheong, Y.K.; Kim, J.M.; Chung, H.T.
    Involvement of anti-inflammatory heme oxygenase-1 in the inhibitory effect of curcumin on the expression of pro-inflammatory inducible nitric oxide synthase in RAW264.7 macrophages (2008), Biomed. Pharmacother., 62, 630-636.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information at low concentrations curcumin induces the expression of HO-1 in RAW264.7 macrophages Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Mus musculus the enzyme has anti-inflammatory activity and is involved in mediation of curcumin's inhibitory effect on inducible NO synthase expression and NO production. Treatment with HO inhibitor abolishes the inhibitory effect of curcumin on lipopolysaccharide-induced NF-kappaB activation, overview biliverdin + Fe2+ + CO + A + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P14901
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-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
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 Mus musculus
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RAW-264.7 cell
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
 Mus musculus biliverdin + Fe2+ + CO + A + H2O
-
 ?
heme + AH2 + O2 the enzyme has anti-inflammatory activity and is involved in mediation of curcumin's inhibitory effect on inducible NO synthase expression and NO production. Treatment with HO inhibitor abolishes the inhibitory effect of curcumin on lipopolysaccharide-induced NF-kappaB activation, overview Mus musculus biliverdin + Fe2+ + CO + A + H2O
-
 ?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
 Mus musculus
HO-1
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 Mus musculus