1.14.14.18: heme oxygenase (biliverdin-producing)
This is an abbreviated version!
For detailed information about heme oxygenase (biliverdin-producing), go to the full flat file.
Word Map on EC 1.14.14.18
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1.14.14.18
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monoxide
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cytoprotective
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endothelial
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necrosis
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dismutase
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protoporphyrin
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erythroid
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2-related
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tnf
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bilirubin
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artery
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malondialdehyde
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lipopolysaccharide
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catalase
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hemin
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neuroprotective
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ischemia
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gsh
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lps
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sod
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anti-oxidant
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mapks
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sirna
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caspase-3
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quinone
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pulmonary
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reperfusion
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lps-induced
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hypoxia
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cyclooxygenase-2
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cox-2
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ferritin
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erk
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nf-e2-related
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anti-apoptotic
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cobalt
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myeloperoxidase
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ischemia-reperfusion
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nrf2-mediated
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pro-oxidant
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kelch-like
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nadph:quinone
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factor-2
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lps-stimulated
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2-like
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erythroid-derived
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oxygenases
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delta-aminolevulinic
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sulforaphane
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hyperbilirubinemia
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medicine
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drug development
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analysis
- 1.14.14.18
- monoxide
-
cytoprotective
- endothelial
- necrosis
- dismutase
- protoporphyrin
-
erythroid
-
2-related
- tnf
- bilirubin
- artery
- malondialdehyde
- lipopolysaccharide
- catalase
- hemin
-
neuroprotective
- ischemia
- gsh
- lps
- sod
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anti-oxidant
- mapks
- sirna
- caspase-3
- quinone
- pulmonary
-
reperfusion
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lps-induced
- hypoxia
- cyclooxygenase-2
- cox-2
- ferritin
- erk
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nf-e2-related
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anti-apoptotic
- cobalt
- myeloperoxidase
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ischemia-reperfusion
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nrf2-mediated
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pro-oxidant
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kelch-like
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nadph:quinone
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factor-2
-
lps-stimulated
-
2-like
-
erythroid-derived
- oxygenases
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delta-aminolevulinic
- sulforaphane
- hyperbilirubinemia
- medicine
- drug development
- analysis
Reaction
+ 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = + + + 3 [oxidized NADPH-hemoprotein reductase] + 3 H2O
Synonyms
biliverdin-producing heme oxygenase, ChuS, ChuZ, EC 1.14.99.3, haem oxygenase, heme oxygenase, heme oxygenase 1, heme oxygenase 2, heme oxygenase-1, heme oxygenase-2, HemO, Hmox1, Hmox1a, Hmox1b, Hmox2, Hmox2a, Hmox2b, HmuO, Hmx1, HO, HO-1, HO-2, Ho1, Ho2, Ho3, HO4, HSP32, HugZ, HY1, inducible heme oxygenase-1, More, MsHO1, ORP33 proteins, oxygenase, heme (decyclizing), pbsA1, PigA, proteins, specific or class, ORP33 (oxygen-regulated protein 33,000-mol.-wt.), Syn HO-1, Syn HO-2
ECTree
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analysis
drug development
medicine
glial HO-1 expression might be an early marker of non-hemorrhagic cell injury in the striatum, time course of induction, overview
analysis
live-cell activity assay based on heterologous coexpression in Escherichia coli of heme oxygenase and its mutants and a fluorescent biliverdin biosensor
analysis
live-cell activity assay based on heterologous coexpression in Escherichia coli of heme oxygenase and its mutants and a fluorescent biliverdin biosensor
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the enzyme is a potential therapeutic target for antimicrobial drug development, computer-aided drug design and screening, overview
drug development
heme oxygenase has cytoprotective properties and may play a role in several disease states, making it an interesting therapeutic target
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cells pretreated with curcumin at 37°C or during a programmed decrease in temperature exhibit increased resistance to oxidative stress-mediated injury, feasibility of modulating HO-1 expression during hydpothermic storage to confer tissues a better protection against damages characteristic of organ transplantation
medicine
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involved in the control of wound healing, heme-induced influx of leukocytes is highly elevated after inhibition of enzyme
medicine
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treatment of streptozotocin-induced diabetic rats with enzyme inhibitor sn protoporphyrin IX. No significant alterations of the enzyme sytem following one week of diabetes. One month of diabetes caused increased oxidative stress in association with 2.5-fold increase in enzyme activity. Sn protoporphyrin IX treatment reduces the number of 8-hydroxy-2deoxyguanosine-positive cardiomycetes and enzyxme activity. Non-diabetic animals treated with hemin exhibit abnormalities similar to diabetic rats
medicine
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chronic ethanol feeding induces 5-aminolevulinic acid synthase-1 (ALAS1) mRNA, cytosolic ALAS1 and mature ALAS1 protein levels, but not those of HO-1 in rat livers, which provides novel insights into the effects of chronic ethanol consumption on hepatic heme biosynthesis and porphyrias
medicine
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outstanding capacity of HO-1-specific CD8+ Tregs to efficiently suppress T cell responses opens new opportunities for therapeutic intervention to modulate immune responses
medicine
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reduction in HO activity may contribute to the protective effect of MEK and ERK inhibitors against heme-mediated neuronal injury
medicine
modulation of Nox4 activity via heme oxygenase-1 may represent a promising therapeutic tool in osteoarthritis
medicine
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the enzyme is a potentially useful parameter for distinguishing active from latent or treated pulmonary tuberculosis
medicine
activity of heme oxygenase-1 interferes with porcine reproductive and respiratory syndrome virus PRRSV replication. The host cell antiviral effect depends on a heme oxygenase-1-biliverdin/bilrubin-nitric oxide-cGMP/PKG cascade
medicine
Hmox1 protects against amyloid beta toxicity via production of CO. Protection does not arise from inhibition of apoptosis-associated K+ efflux, but rather by inhibition of AMP-dependent protein kinase activation
medicine
induction or exogenous overexpression of heme oxygenase HO-1 effectively inhibits Dengue virus DENV replication in DENV-infected Huh-7 cells. This antiviral is attenuated by inhibitor tin protoporphyrin. Biliverdin but not carbon monoxide and ferrous ions, mediates the HO-1-induced anti-DENV effect by non-competitively inhibiting DENV protease. HO-1 induction or its exogenous overexpression, rescues DENV-suppressed antiviral interferon response. HO-1 induction by cobalt protoporphyrin and andrographolide leads to a significant delay in the onset of disease and mortality, and virus load in the infected mice's brains