1.14.14.18: heme oxygenase (biliverdin-producing)
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For detailed information about heme oxygenase (biliverdin-producing), go to the full flat file.
Word Map on EC 1.14.14.18
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1.14.14.18
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monoxide
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cytoprotective
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endothelial
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necrosis
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dismutase
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protoporphyrin
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erythroid
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2-related
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tnf
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bilirubin
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artery
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malondialdehyde
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lipopolysaccharide
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catalase
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hemin
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neuroprotective
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ischemia
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gsh
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lps
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sod
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anti-oxidant
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mapks
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sirna
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caspase-3
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quinone
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pulmonary
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reperfusion
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lps-induced
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hypoxia
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cyclooxygenase-2
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cox-2
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ferritin
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erk
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nf-e2-related
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anti-apoptotic
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cobalt
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myeloperoxidase
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ischemia-reperfusion
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nrf2-mediated
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pro-oxidant
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kelch-like
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nadph:quinone
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factor-2
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lps-stimulated
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2-like
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erythroid-derived
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oxygenases
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delta-aminolevulinic
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sulforaphane
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hyperbilirubinemia
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medicine
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drug development
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analysis
- 1.14.14.18
- monoxide
-
cytoprotective
- endothelial
- necrosis
- dismutase
- protoporphyrin
-
erythroid
-
2-related
- tnf
- bilirubin
- artery
- malondialdehyde
- lipopolysaccharide
- catalase
- hemin
-
neuroprotective
- ischemia
- gsh
- lps
- sod
-
anti-oxidant
- mapks
- sirna
- caspase-3
- quinone
- pulmonary
-
reperfusion
-
lps-induced
- hypoxia
- cyclooxygenase-2
- cox-2
- ferritin
- erk
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nf-e2-related
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anti-apoptotic
- cobalt
- myeloperoxidase
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ischemia-reperfusion
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nrf2-mediated
-
pro-oxidant
-
kelch-like
-
nadph:quinone
-
factor-2
-
lps-stimulated
-
2-like
-
erythroid-derived
- oxygenases
-
delta-aminolevulinic
- sulforaphane
- hyperbilirubinemia
- medicine
- drug development
- analysis
Reaction
Synonyms
biliverdin-producing heme oxygenase, ChuS, ChuZ, EC 1.14.99.3, haem oxygenase, heme oxygenase, heme oxygenase 1, heme oxygenase 2, heme oxygenase-1, heme oxygenase-2, HemO, Hmox1, Hmox1a, Hmox1b, Hmox2, Hmox2a, Hmox2b, HmuO, Hmx1, HO, HO-1, HO-2, Ho1, Ho2, Ho3, HO4, HSP32, HugZ, HY1, inducible heme oxygenase-1, More, MsHO1, ORP33 proteins, oxygenase, heme (decyclizing), pbsA1, PigA, proteins, specific or class, ORP33 (oxygen-regulated protein 33,000-mol.-wt.), Syn HO-1, Syn HO-2
ECTree
1.14.14.18 heme oxygenase (biliverdin-producing)Advanced search results
results (
results (Source Tissue
Source Tissue on EC 1.14.14.18 - heme oxygenase (biliverdin-producing)
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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in vivo, high HO-1 expression. HO-1 protein is strongly expressed in proliferative, Ki67-positive cytotrophoblasts of cell columns. HO-1 is strongly expressed in cycling cytotrophoblasts of first trimester explant cultures
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increased expression on inflammation, particularly in infiltrating cells
neutrophil HO-1 expression is similar in rats receiving burn injury alone compared with shams gavaged with saline, however, as compared with rats receiving EtOH intoxication, neutrophil HO-1 expression in burn rats is significantly decreased. Furthermore, a significant decrease in neutrophil HO-1 expression is observed in rats receiving a combined insult of EtOH intoxication and burn injury compared with rats receiving either sham or burn injury alone
expression and immunohistochemic analysis in veno-occlusive priapism, overview
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HLA-A2/HO-1-restricted, CD8+ T cells in peripheral blood lymphocytes of cancer patients
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activity is very low in obstructive azoospermia specimens, low in nonobstructive azoospermia, moderate in oligozoospermia while higher in normozoospermia. HO-2 expression in all studied groups whereas HO-1 is highly expressed in fertile normozoospermic group compared with other groups
obtained from the knee joints at the time of joint surgery or synovectomy, performed as a normal part of clinical care, from 20 rheumatoid arthritis patients, HO-1 expression analysis
additional information
HCV-infected liver biopsies and core protein-expressing hepatocytes show diminished levels of heme oxygenase-1
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high level of heme oxygenase-2 in the outer medulla followed by inner medulla/papilla and cortex, heme oxygenase-1 is barely detectable in tissue from untreated animals but increases strongly in SnCl2 treated animals
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24 h after a CoCl2 injection heme-oxygenase-1 activity increases 13fold, enzyme may play a role in the liver oxidative-stress defence
HO-1 is expressed primarily in Kupffer cells, HCV-infected liver biopsies and core protein-expressing hepatocytes show diminished levels of heme oxygenase-1
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288603, 438243, 438244, 438247, 438248, 438250, 438256, 438258, 438261, 438275, 674063, 703698, 742811
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enzyme is constitutively expressed in Kupffer cells, inducible in hepatocytes
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increased expression on inflammation, particularly in infiltrating cells
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highest expression of HO-1 mRNA levels in the spleen, 6.6fold of those in the liver
additional information
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in vivo, no HO-1 expression in extravillous trophoblasts and in nonproliferating, Kip2/p57-positive extravillous trophoblasts
additional information
isozyme HO-2 has a wider tissue distribution than isozyme HO-1
additional information
isozyme HO-2 has a wider tissue distribution than isozyme HO-1
additional information
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isozyme HO-2 has a wider tissue distribution than isozyme HO-1
additional information
expressions of MsHO1 are higher in alfalfa stems and leaves than those in germinating seeds and roots, expression patterns, overview
additional information
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expressions of MsHO1 are higher in alfalfa stems and leaves than those in germinating seeds and roots, expression patterns, overview
additional information
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expression of HO-1 is tissue-specific, and there is a correspondence between levels of HO-1 mRNA and protein
