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Literature summary for 1.14.14.18 extracted from

  • Chung, H.T.; Choi, B.M.; Kwon, Y.G.; Kim, Y.M.
    Interactive relations between nitric oxide (NO) and carbon monoxide (CO): heme oxygenase-1/CO pathway is a key modulator in NO-mediated antiapoptosis and anti-inflammation (2008), Methods Enzymol., 441, 329-338.
    View publication on PubMed
Search for more literature for 1.14.14.18

Activating Compound

Activating Compound Comment Organism Structure
additional information HO-1 is induced by NO in macrophages and hepatocytes inhibiting apoptotic cell death of hepatocytes via the regulation of cellular homeostasis of prooxidant iron Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information protective effect by iron chelation in HO1-deficient fibroblasts Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Homo sapiens CO plays a role in cGMP production, p38 mitogen-activated protein kinase activation, and nuclear factor-kB activation, as part of the heme oxygenase-1/carbon monoxide, HO-1/CO, system, overview, correlation of HO-1-mediated cytoprotection with a decrease in intracellular free iron amounts. Biliverdin is a third generated heme catabolite by HO-1 and is converted to bilirubin by the catalytic reaction of biliverdin reductase. Both compounds are reducing species and hence may play a role in the protective response to vascular injury by oxidative stress biliverdin + Fe2+ + CO + A + H2O
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 ?
additional information Homo sapiens heme oxygenase-1/CO pathway is a key modulator in NO-mediated antiapoptosis and anti-inflammation, mechanisms, overview, mechanisms for the HO-1-mediated inhibition of NO production, activation of the PI3K/Akt pathway, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09601
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
 Homo sapiens biliverdin + Fe2+ + CO + A + H2O
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 ?
heme + AH2 + O2 CO plays a role in cGMP production, p38 mitogen-activated protein kinase activation, and nuclear factor-kB activation, as part of the heme oxygenase-1/carbon monoxide, HO-1/CO, system, overview, correlation of HO-1-mediated cytoprotection with a decrease in intracellular free iron amounts. Biliverdin is a third generated heme catabolite by HO-1 and is converted to bilirubin by the catalytic reaction of biliverdin reductase. Both compounds are reducing species and hence may play a role in the protective response to vascular injury by oxidative stress Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
 ?
additional information heme oxygenase-1/CO pathway is a key modulator in NO-mediated antiapoptosis and anti-inflammation, mechanisms, overview, mechanisms for the HO-1-mediated inhibition of NO production, activation of the PI3K/Akt pathway, overview Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
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 Homo sapiens
HO-1
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 Homo sapiens