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1.14.14.18: heme oxygenase (biliverdin-producing)

This is an abbreviated version!
For detailed information about heme oxygenase (biliverdin-producing), go to the full flat file.

Word Map on EC 1.14.14.18

Reaction

protoheme
+ 3 [reduced NADPH-hemoprotein reductase] + 3 O2 =
Biliverdin
 +
Fe2+
 +
CO
 + 3 [oxidized NADPH-hemoprotein reductase] + 3 H2O

Synonyms

biliverdin-producing heme oxygenase, ChuS, ChuZ, EC 1.14.99.3, haem oxygenase, heme oxygenase, heme oxygenase 1, heme oxygenase 2, heme oxygenase-1, heme oxygenase-2, HemO, Hmox1, Hmox1a, Hmox1b, Hmox2, Hmox2a, Hmox2b, HmuO, Hmx1, HO, HO-1, HO-2, Ho1, Ho2, Ho3, HO4, HSP32, HugZ, HY1, inducible heme oxygenase-1, More, MsHO1, ORP33 proteins, oxygenase, heme (decyclizing), pbsA1, PigA, proteins, specific or class, ORP33 (oxygen-regulated protein 33,000-mol.-wt.), Syn HO-1, Syn HO-2

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.18 heme oxygenase (biliverdin-producing)

Specific Activity

Specific Activity on EC 1.14.14.18 - heme oxygenase (biliverdin-producing)

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00000625
-
activity in kidney microsomes, micromol bilirubin/min/mg
0.000015
-
cavernous tissue of sildenafil-treated rats
0.00004
spleen microsomes, pH 7.4, 37°C
0.000175
-
spleen enzyme
0.00046
-
NADH-dependent heme degradation in heart mitochondria
0.0064
-
testis heme oxygenase-2, partialy purified
0.017
-
28000 Da recombinant tryptic fragment of heme oxygenase-2
0.024
-
recombinant C-terminal truncated heme oxygenase-1
0.05
-
hematoheme oxidation
0.052
-
protoheme oxidation
0.067
-
testicular heme oxygenase-2
0.0705
purified recombinant wild-type enzyme
0.072
-
37°C, presence of Zn protoporphyrin IX
0.075
-
37°C, presence of Zn protoporphyrin IX plus 0.2 mM Cd2+
0.075 - 0.1
-
liver heme oxygenase from Co-treated animals, 2 fractions during purification
0.095
-
testis heme oxygenase-2
0.101
purified recombinant HO-1 mutant R254K
0.104
-
liver heme oxygenase-1
0.11
-
liver heme oxygenase-1
0.113
-
spleen enzyme
0.138
-
liver heme oxygenase-1
0.142
-
37°C, control
0.433
-
-
0.641
-
37°C, presence of 0.2 mM Cd2+
additional information