Literature summary for 1.14.14.18 extracted from

Frank, J.; Lornejad-Schaefer, M.R.; Schoeffl, H.; Flaccus, A.; Lambert, C.; Biesalski, H.K.
Inhibition of heme oxygenase-1 increases responsiveness of melanoma cells to ALA-based photodynamic therapy (2007), Int. J. Oncol., 31, 1539-1545.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	the enzyme is induced by 5-aminolevulinic acid, the activation is reduced to 29% by gene silencing with siRNA, overview	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
quantitative enzyme expression analysis	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	enzyme downregulation by expression of HO-1 siRNA in WM451Lu cells, reverses the upregulating effect of 5-aminolevulinic acid, oerview	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Sn-protoporphyrin IX	i.e. SNPPIX	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09601	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
melanoma cell	quantitative HO-1 expression analysis	Homo sapiens	-
WM-451Lu cell	quantitative HO-1 expression analysis	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
heme oxygenase-1	-	Homo sapiens
HO-1	-	Homo sapiens

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Release 2023.1 (January 2023)