1.1.1.85: 3-isopropylmalate dehydrogenase

This is an abbreviated version, for detailed information about 3-isopropylmalate dehydrogenase, go to the full flat file.

Reaction

(2R,3S)-3-isopropylmalate
+
NAD+
=
(2S)-2-isopropyl-3-oxosuccinate
+
NADH
+
H+

Synonyms

2-hydroxy-4-methyl-3-carboxyvalerate:NAD+ oxidoreductase, 2R,3S-isopropylmalate:NAD+ oxidoreductase (decaboxylating), 3-IPM dehydrogenase, 3-IPM-DH, 3-isopropylmalate dehydrogenase, 3-isopropylmalateDH, APS IPMDH, beta-IPM dehydrogenase, beta-IPMDH, beta-isopropylmalate dehydrogenase, beta-isopropylmalic enzyme, Bs3-isopropylmalateDH, dehydrogenase, 3-isopropylmalate, IMDH, IPMDH, IPMDH1, IPMDH2, IPMDH3, isopropylmalate dehydrogenase, leuB, NAD-dependent isopropylmalate dehydrogenase, Saci_0600, SbIPMDH, SoIPMDH, threo-Ds-3-isopropylmalate dehydrogenase, Tt-beta-3-isopropylmalateDH, two-domain 3-isopropylmalate dehydrogenase, Ydr417cp

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.85 3-isopropylmalate dehydrogenase

KM Value

KM Value on EC 1.1.1.85 - 3-isopropylmalate dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0035 - 3.73
(2R,3S)-3-isopropylmalate
0.045 - 0.502
3-(2'-methylthio)ethylmalate
0.013
3-ethylmalate
-
-
0.11
3-isoamylmalate
-
-
0.0039 - 0.026
3-isopropylmalate
0.05
3-methylmalate
-
-
0.074
3-tert-butylmalate
-
-
0.0011
D-3-ethylmalate
pH 8.0
0.0015
D-3-isobutylmalate
pH 8.0
0.0058
D-3-isopentylmalate
pH 8.0
0.0012 - 0.0267
D-3-isopropylmalate
0.0037
D-3-methylmalate
pH 8.0
0.0023
D-3-t-butylmalate
pH 8.0
0.41 - 4
D-malate
0.002 - 0.0133
DL-3-isopropylmalate
0.019
dl-erythro-beta-ethylmalate
-
pH 9.0, 22C
0.0092
erythro-Lg-beta-isopropylmalate
-
pH 9.0, 22C
-
0.09
ethylmalate
-
pH 7.6
5.9
homoisocitrate
at pH 8.0 and 60C
0.000017 - 0.316
isopropylmalate
12
L-malate
-
pH 9.0
0.0326 - 35.59
malate
0.00321 - 3.56
NAD+
0.014 - 6.579
NADP+
0.105
propylmalate
-
pH 7.6
0.0407 - 1.21
Tartrate
0.214
tert-butylmalate
-
pH 7.6
0.051
thionicotinamide-NAD+
-
pH 9.0, 22C
0.0061 - 0.0161
threo-D,L-isopropylmalate
0.08
threo-Ds-3-Isopropylmalate
-
60C
additional information
additional information
-