1.1.1.85: 3-isopropylmalate dehydrogenase

This is an abbreviated version, for detailed information about 3-isopropylmalate dehydrogenase, go to the full flat file.

Reaction

(2R,3S)-3-isopropylmalate
+
NAD+
=
(2S)-2-isopropyl-3-oxosuccinate
+
NADH
+
H+

Synonyms

2-hydroxy-4-methyl-3-carboxyvalerate:NAD+ oxidoreductase, 2R,3S-isopropylmalate:NAD+ oxidoreductase (decaboxylating), 3-IPM dehydrogenase, 3-IPM-DH, 3-isopropylmalate dehydrogenase, 3-isopropylmalateDH, APS IPMDH, beta-IPM dehydrogenase, beta-IPMDH, beta-isopropylmalate dehydrogenase, beta-isopropylmalic enzyme, Bs3-isopropylmalateDH, dehydrogenase, 3-isopropylmalate, IMDH, IPMDH, IPMDH1, IPMDH2, IPMDH3, isopropylmalate dehydrogenase, leuB, NAD-dependent isopropylmalate dehydrogenase, Saci_0600, SbIPMDH, SoIPMDH, threo-Ds-3-isopropylmalate dehydrogenase, Tt-beta-3-isopropylmalateDH, two-domain 3-isopropylmalate dehydrogenase, Ydr417cp

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.85 3-isopropylmalate dehydrogenase

Turnover Number

Turnover Number on EC 1.1.1.85 - 3-isopropylmalate dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0025 - 48.1
(2R,3S)-3-isopropylmalate
0.016 - 0.85
3-(2'-methylthio)ethylmalate
38
3-ethylmalate
Acidithiobacillus ferrooxidans
-
-
20
3-isoamylmalate
Acidithiobacillus ferrooxidans
-
-
3.8 - 28
3-isopropylmalate
28
3-methylmalate
Acidithiobacillus ferrooxidans
-
-
2.7
3-tert-butylmalate
Acidithiobacillus ferrooxidans
-
-
3.1
D-3-ethylmalate
Sulfolobus tokodaii
P50455
pH 8.0
3.1
D-3-isobutylmalate
Sulfolobus tokodaii
P50455
pH 8.0
2.7
D-3-isopentylmalate
Sulfolobus tokodaii
P50455
pH 8.0
2.36 - 117
D-3-isopropylmalate
3.5
D-3-methylmalate
Sulfolobus tokodaii
P50455
pH 8.0
0.96
D-3-t-butylmalate
Sulfolobus tokodaii
P50455
pH 8.0
70
ethylmalate
Escherichia coli
-
pH 7.6
0.26
homoisocitrate
Sulfolobus acidocaldarius
Q4JB37
at pH 8.0 and 60°C
0.09 - 69
isopropylmalate
0.19 - 10.6
malate
0.15 - 117
NAD+
0.09 - 4.69
NADP+
0.1 - 0.26
Tartrate
6
tert-butylmalate
Escherichia coli
-
pH 7.6
additional information
additional information
Thermus thermophilus
-
the cold adaption results from the destabilization of the ternary complex caused by increase in the volume of the residue at position 126
-