1.1.1.85: 3-isopropylmalate dehydrogenase This is an abbreviated version! For detailed information about 3-isopropylmalate dehydrogenase, go to the full flat file .
Reaction
(2R,3S)-3-isopropylmalate +
NAD+ =
(2S)-2-isopropyl-3-oxosuccinate +
NADH +
H+
Synonyms 2-hydroxy-4-methyl-3-carboxyvalerate:NAD+ oxidoreductase, 2R,3S-isopropylmalate:NAD+ oxidoreductase (decaboxylating), 3-IPM dehydrogenase, 3-IPM-DH, 3-isopropylmalate dehydrogenase, 3-isopropylmalateDH, APS IPMDH, beta-IPM dehydrogenase, beta-IPMDH, beta-isopropylmalate dehydrogenase, beta-isopropylmalic enzyme, Bs3-isopropylmalateDH, dehydrogenase, 3-isopropylmalate, IMDH, IPMDH, IPMDH1, IPMDH2, IPMDH3, isopropylmalate dehydrogenase, leuB, NAD-dependent isopropylmalate dehydrogenase, Saci_0600, SbIPMDH, SoIPMDH, threo-Ds-3-isopropylmalate dehydrogenase, Tt-beta-3-isopropylmalateDH, two-domain 3-isopropylmalate dehydrogenase, Ydr417cp
ECTree
Organism
Organism on EC 1.1.1.85 - 3-isopropylmalate dehydrogenase
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No 1023
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brenda
No 1023
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brenda
gene leuB
SwissProt
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brenda
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UniProt
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SwissProt
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gene leu2A
SwissProt
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SwissProt
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no 38-2
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Bacillus sp. (in: Bacteria) no 38-2
no 38-2
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gene leuB
SwissProt
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SwissProt
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gene leu2
SwissProt
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TIT 01010
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TIT 01010
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M588
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M588
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SwissProt
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i.e. Eremothecium gossypii, gene leu2
SwissProt
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SwissProt
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SwissProt
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strain C175/CBS 8195, gene LEU2
SwissProt
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strain C175/CBS 8195, gene LEU2
SwissProt
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gene leuB
SwissProt
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UniProt
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UniProt
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Uniprot
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Uniprot
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gene leuB
SwissProt
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gene leu2
SwissProt
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gene leu2
SwissProt
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Uniprot
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UniProt
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UniProt
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UniProt
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SwissProt
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two ancestral sequences of 3-isopropylmalate dehydrogenase (ancIPMDH-IQ and ancIPMDH-ML) are designed by an ancestral sequence reconstruction technique based on a phylogenetic analysis of extant homologous amino acid sequences. Genes encoding the designed sequences are artificially synthesized and expressed in Escherichia coli. They have considerably higher low-temperature catalytic activity as compared with the Thermus thermophilus enzyme
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gene leuB
SwissProt
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SwissProt
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gene leuB
SwissProt
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SwissProt
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i.e. Septoria tritici, gene leuC
SwissProt
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gene leu2
SwissProt
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gene leuB
SwissProt
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SwissProt
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UniProt
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ecotype Col-1, genes IMD1, IMD2, and IMD3
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ecotype Columbia
UniProt
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isoform IPMDH1
UniProt
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isoform IPMDH2
UniProt
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isoform IPMDH3
UniProt
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gene leu2
SwissProt
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SwissProt
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gene leuB
SwissProt
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orf Ydr417C
SwissProt
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gene leuB
SwissProt
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strain leu A-124
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Uniprot
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Uniprot
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Uniprot
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UniProt
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UniProt
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SwissProt
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gene leuB
SwissProt
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639130 , 639131 , 639133 , 639136 , 639138 , 639139 , 639140 , 639146 , 639152 , 639153 , 639155 , 639156 , 639157 , 639158 , 639159 , 639160 , 639164 , 639165 , 639167 , 657223 -
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SwissProt
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Swissprot
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SwissProt
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SwissProt
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SwissProt
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SwissProt
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SwissProt
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gene leuB
SwissProt
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gene leuB
SwissProt
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