1.1.1.85: 3-isopropylmalate dehydrogenase

This is an abbreviated version, for detailed information about 3-isopropylmalate dehydrogenase, go to the full flat file.

Reaction

(2R,3S)-3-isopropylmalate
+
NAD+
=
(2S)-2-isopropyl-3-oxosuccinate
+
NADH
+
H+

Synonyms

2-hydroxy-4-methyl-3-carboxyvalerate:NAD+ oxidoreductase, 2R,3S-isopropylmalate:NAD+ oxidoreductase (decaboxylating), 3-IPM dehydrogenase, 3-IPM-DH, 3-isopropylmalate dehydrogenase, 3-isopropylmalateDH, APS IPMDH, beta-IPM dehydrogenase, beta-IPMDH, beta-isopropylmalate dehydrogenase, beta-isopropylmalic enzyme, Bs3-isopropylmalateDH, dehydrogenase, 3-isopropylmalate, IMDH, IPMDH, IPMDH1, IPMDH2, IPMDH3, isopropylmalate dehydrogenase, leuB, NAD-dependent isopropylmalate dehydrogenase, Saci_0600, SbIPMDH, SoIPMDH, threo-Ds-3-isopropylmalate dehydrogenase, Tt-beta-3-isopropylmalateDH, two-domain 3-isopropylmalate dehydrogenase, Ydr417cp

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.85 3-isopropylmalate dehydrogenase

Molecular Weight

Molecular Weight on EC 1.1.1.85 - 3-isopropylmalate dehydrogenase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
35000
-
2 * 35000, sedimentation equilibrium centrifugation after treatment with mercaptoethanol and 6 M guanidine-HCl
36000
-
3 * 36000, or 4 * 360000, SDS-PAGE; 3 * or 4 * 36000, SDS-PAGE
36832
4 * 37000, SDS-PAGE, 4 * 36832, calculated
37000
4 * 37000, SDS-PAGE, 4 * 36832, calculated
38000
-
2 * 38000, SDS-PAGE
38700
-
2 * 38700, nucleotide sequence analysis
39085
-
1 * 39085, enzyme exists in a dynamic monomer-dimer equilibrium, calculation from nucleotide sequence; 2 * 39085, enzyme exists in a dynamic monomer-dimer equilibrium, calculation from nucleotide sequence
39808
-
2 * 39808, calculation from nucleotide sequence
44000
-
2 * 44000, monomer-dimer equilibrium in aqueous solution, SDS-PAGE
50000
-
gel filtration
58000
-
gel filtration
68000
-
monomer-dimer equilibrium in aqueous solution, gel filtration
72000
-
gel filtration
73000
-
equilibrium sedimentation
76960
-
2 * 76960, sequence calculation
78780
2 * 78780, sequence calculation
90000
-
gel electrophoresis
110000
-
gel filtration
130000
gel filtration
136000
sedimentation equilibrium analysis
360000
-
3 * 36000, or 4 * 360000, SDS-PAGE