1.1.1.85: 3-isopropylmalate dehydrogenase

This is an abbreviated version, for detailed information about 3-isopropylmalate dehydrogenase, go to the full flat file.

Reaction

(2R,3S)-3-isopropylmalate
+
NAD+
=
(2S)-2-isopropyl-3-oxosuccinate
+
NADH
+
H+

Synonyms

2-hydroxy-4-methyl-3-carboxyvalerate:NAD+ oxidoreductase, 2R,3S-isopropylmalate:NAD+ oxidoreductase (decaboxylating), 3-IPM dehydrogenase, 3-IPM-DH, 3-isopropylmalate dehydrogenase, 3-isopropylmalateDH, APS IPMDH, beta-IPM dehydrogenase, beta-IPMDH, beta-isopropylmalate dehydrogenase, beta-isopropylmalic enzyme, Bs3-isopropylmalateDH, dehydrogenase, 3-isopropylmalate, IMDH, IPMDH, IPMDH1, IPMDH2, IPMDH3, isopropylmalate dehydrogenase, leuB, NAD-dependent isopropylmalate dehydrogenase, Saci_0600, SbIPMDH, SoIPMDH, threo-Ds-3-isopropylmalate dehydrogenase, Tt-beta-3-isopropylmalateDH, two-domain 3-isopropylmalate dehydrogenase, Ydr417cp

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.85 3-isopropylmalate dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.85 - 3-isopropylmalate dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2R,3S)-3-isopropylmalate + NAD+
(2S)-2-isopropyl-3-oxosuccinate + NADH + H+
show the reaction diagram
(2R,3S)-3-isopropylmalate + NAD+
2-ketoisocaproate + NADH + CO2
show the reaction diagram
-
-
-
-
?
(2R,3S)-3-isopropylmalate + NAD+
2-oxoisocaproate + NADH + CO2
show the reaction diagram
(2R,3S)-3-isopropylmalate + NAD+
2-oxoisocaproate + NADH + H+ + CO2
show the reaction diagram
-
-
-
-
?
(2R,3S)-3-isopropylmalate + NAD+
4-methyl-2-oxovalerate + CO2 + NADH + H+
show the reaction diagram
-
-
-
?
(2R,3S)-3-isopropylmalate + NAD+
?
show the reaction diagram
(2R,3S)-3-isopropylmalate + NAD+
D-3-isopropyl-2-oxosuccinate + NADH + H+
show the reaction diagram
(2R,3S)-3-isopropylmalate + NAD+
isopropyl-3-oxosuccinate + NADH + H+
show the reaction diagram
-
-
-
r
(2R,3S)-3-isopropylmalate + thionicotinamide NAD+
2-oxoisohexanoate + thionicotinamideNADH + CO2
show the reaction diagram
(S)-malate + NAD+
pyruvate + NADH + CO2
show the reaction diagram
-
12% of the activity with 3-isopropylmalate
-
-
?
3-(2'-methylthio)ethylmalate + NAD+
? + NADH + H+
show the reaction diagram
-
-
-
?
3-ethylmalate + NAD+
3-ethylpyruvate + NADH + CO2
show the reaction diagram
3-isoamylmalate + NAD+
3-isoamylpyruvate + NADH + CO2
show the reaction diagram
-
-
-
-
?
3-isopropylmalate + NAD+
2-ketoisocaproate + CO2 + NADH + H+
show the reaction diagram
3-isopropylmalate + NAD+
2-ketoisocaproate + NADH + CO2
show the reaction diagram
3-isopropylmalate + NAD+
?
show the reaction diagram
-
-
-
-
?
3-methylmalate + NAD+
3-methylpyruvate + NADH + CO2
show the reaction diagram
-
-
-
-
?
3-tert-butylmalate + NAD+
3-tert-butylpyruvate + NADH + CO2
show the reaction diagram
-
-
-
-
?
beta-methylmalate + NAD+
2-oxobutyrate + NADH + CO2
show the reaction diagram
-
enzyme catalyzes the final step in the pyruvate pathway to 2-oxobutyrate
-
-
?
D-3-ethylmalate + NAD+
D-3-ethyl-2-oxosuccinate + NADH + H+
show the reaction diagram
D-3-isobutylmalate + NAD+
D-3-isobutyl-2-oxosuccinate + NADH + H+
show the reaction diagram
D-3-isopentylmalate + NAD+
D-3-isopentyl-2-oxosuccinate + NADH + H+
show the reaction diagram
D-3-methylmalate + NAD+
D-3-methyl-2-oxosuccinate + NADH + H+
show the reaction diagram
-
-
-
?
D-3-t-butylmalate + NAD+
D-3-t-butyl-2-oxosuccinate + NADH + H+
show the reaction diagram
-
-
-
?
D-malate + NAD+
pyruvate + NADH + CO2
show the reaction diagram
DL-3-isopropylmalate + NAD+
DL-isopropyl-3-oxosuccinate + NADH + H+
show the reaction diagram
-
-
-
-
?
ethylmalate + NAD+
ethylpyruvate + NADH + CO2
show the reaction diagram
-
-
-
-
?
homoisocitrate + NAD+
? + NADH + H+
show the reaction diagram
isopropylmalate + NAD+
?
show the reaction diagram
-
-
-
-
?
malate + NAD+
3-oxosuccinate + NADH + H+
show the reaction diagram
-
-
-
?
malate + NAD+
pyruvate + NADH + CO2
show the reaction diagram
malate + NADP+
pyruvate + NADPH + CO2
show the reaction diagram
-
-
-
-
?
tartrate + NAD+
?
show the reaction diagram
-
-
-
-
?
tartrate + NADP+
?
show the reaction diagram
-
-
-
-
?
tert-butylmalate + NAD+
tert-butylpyruvate + NADH + CO2
show the reaction diagram
-
-
-
-
?
threo-D-3-isopropylmalate + NAD+
?
show the reaction diagram
threo-DL-isopropylmalate + NAD+
2-isopropyl-3-oxosuccinate + NADH
show the reaction diagram
additional information
?
-