1.1.1.31: 3-hydroxyisobutyrate dehydrogenase

This is an abbreviated version, for detailed information about 3-hydroxyisobutyrate dehydrogenase, go to the full flat file.

Reaction

3-hydroxy-2-methylpropanoate
+
NAD+
=
2-Methyl-3-oxopropanoate
+
NADH
+
H+

Synonyms

3-HIBADH, 3-hydroxyisobutyrate dehydrogenase, 3-hydroxyisobutyrate dehydrogenase-I, 3HIBDH-IV, 3HIBDHI, beta-hydroxyisobutyrate dehydrogenase, HIBADH, HIBDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.31 3-hydroxyisobutyrate dehydrogenase

Specific Activity

Specific Activity on EC 1.1.1.31 - 3-hydroxyisobutyrate dehydrogenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0037
-
index patient with 3-hydroxyisobutyric acidia
0.0042
-
patient 2 with 3-hydroxyisobutyric acidia
0.0046
-
patient 1 with 3-hydroxyisobutyric acidia
0.091
-
homogenate
1.62
-
crude extract, at 37C and pH 9.0
8.7
-
purified enzyme
8.77
-
pH 8.5, 37C; purified enzyme, pH 8.5, 37C
20.9
-
-
58.67
-
after 36.22fold purification, at 37C and pH 9.0