1.1.1.31: 3-hydroxyisobutyrate dehydrogenase

This is an abbreviated version, for detailed information about 3-hydroxyisobutyrate dehydrogenase, go to the full flat file.

Reaction

3-hydroxy-2-methylpropanoate
+
NAD+
=
2-Methyl-3-oxopropanoate
+
NADH
+
H+

Synonyms

3-HIBADH, 3-hydroxyisobutyrate dehydrogenase, 3-hydroxyisobutyrate dehydrogenase-I, 3HIBDH-IV, 3HIBDHI, beta-hydroxyisobutyrate dehydrogenase, HIBADH, HIBDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.31 3-hydroxyisobutyrate dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.31 - 3-hydroxyisobutyrate dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(R)-3-hydroxy-2-methylpropanoate
-
competitive inhibitor of the S-isomer
Ag+
-
complete inhibition at 1 mM
AgNO3
Hg2+
-
complete inhibition at 1 mM
HgCl2
iodoacetate
-
-
K+
-
about 92.11% residual activity at 1 mM
Li+
-
about 92.32% residual activity at 1 mM
NADH
-
product inhibition
NH4+
-
about 90.17% residual activity at 1 mM
p-chloromercuribenzoate
ZnCl2
-
0.2 mM, 60% inhibition; inhibits approximately 60% of 3-HIBADH activity at 0.2 mM but shows no effect at 0.005 mM
additional information
-
is not inhibited by 1-propanol, lactate potassium, malate potassium, malonate potassium, acetaldehyde, ethanol, and glycerin
-