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Literature summary for 1.1.1.31 extracted from
- The purification and properties of beta-hydroxyisobutyrate dehydrogenase (1956), J. Biol. Chem., 225, 511-521.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| HgCl2 | - |
Sus scrofa |  |
| iodoacetate | - |
Sus scrofa | |
| p-chloromercuribenzoate | - |
Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.054 | - |
NAD+ | - |
Sus scrofa | |
| 0.12 | - |
DL-3-hydroxyisobutyrate | - |
Sus scrofa | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Sus scrofa | - |
| kidney | - |
Sus scrofa | - |
| liver | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 20.9 | - |
- |
Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DL-3-hydroxyisobutyrate + NAD+ | - |
Sus scrofa | methylmalonate semialdehyde + NADH + H+ | - |
r | |
| L-3-hydroxyisobutyrate + NAD+ | - |
Sus scrofa | L-2-methyl-3-oxopropionate + NADH | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
- |
Sus scrofa |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 11 | - |
Sus scrofa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Sus scrofa | |
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Release 2023.1 (January 2023)
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