1.1.1.31: 3-hydroxyisobutyrate dehydrogenase

This is an abbreviated version, for detailed information about 3-hydroxyisobutyrate dehydrogenase, go to the full flat file.

Reaction

3-hydroxy-2-methylpropanoate
+
NAD+
=
2-Methyl-3-oxopropanoate
+
NADH
+
H+

Synonyms

3-HIBADH, 3-hydroxyisobutyrate dehydrogenase, 3-hydroxyisobutyrate dehydrogenase-I, 3HIBDH-IV, 3HIBDHI, beta-hydroxyisobutyrate dehydrogenase, HIBADH, HIBDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.31 3-hydroxyisobutyrate dehydrogenase

KCat KM Value

KCat KM Value on EC 1.1.1.31 - 3-hydroxyisobutyrate dehydrogenase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
37.1 - 604.1
(S)-3-hydroxyisobutyrate
42816
0.0125
3-hydroxypropionate
Bacillus cereus
-
pH 8.5, 37°C
1632
10.23 - 15.4
3-hydroxypropionic acid
13715
0.404 - 1.46
L-serine
95
1.433 - 4.04
methyl (2S)-3-hydroxy-2-methylpropanoate
213969
0.275 - 0.75
methyl DL-serine
213968
42.44 - 55.1
NAD+
7