1.1.1.31: 3-hydroxyisobutyrate dehydrogenase

This is an abbreviated version, for detailed information about 3-hydroxyisobutyrate dehydrogenase, go to the full flat file.

Reaction

3-hydroxy-2-methylpropanoate
+
NAD+
=
2-Methyl-3-oxopropanoate
+
NADH
+
H+

Synonyms

3-HIBADH, 3-hydroxyisobutyrate dehydrogenase, 3-hydroxyisobutyrate dehydrogenase-I, 3HIBDH-IV, 3HIBDHI, beta-hydroxyisobutyrate dehydrogenase, HIBADH, HIBDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.31 3-hydroxyisobutyrate dehydrogenase

Reference

Reference on EC 1.1.1.31 - 3-hydroxyisobutyrate dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Worral, E.B.; Gassain, S.; Cox, D.J.; Sugden, M.C.; Palmer, T.N.
3-Hydroxyisobutyrate dehydrogenase, an impurity in commercial 3-hydroxybutyrate dehydrogenase
Biochem. J.
241
297-300
1987
Rhodobacter sphaeroides
Manually annotated by BRENDA team
Rougraff, P.M.; Paxton, R.; Kuntz, M.J.; Crabb, D.W.; Harris, R.A
Purification and characterization of 3-hydroxyisobutyrate dehydrogenase from rat liver
J. Biol. Chem.
263
327-331
1988
Oryctolagus cuniculus
Manually annotated by BRENDA team
Hasegawa, J
Distribution in organisms and stereospecificity of beta-hydroxyisobutyrate dehydrogenase
Agric. Biol. Chem.
45
2899-2901
1981
Bos taurus, Candida parapsilosis, Candida rugosa, Corynebacterium hydrocarbons, Endomyces reessii, Micrococcus flavus, Micrococcus luteus, Nocardia lyena, Oryctolagus cuniculus, Pseudomonas aeruginosa, Pseudomonas dacunhae, Rhodotorula mucilaginosa, Sus scrofa, Trichosporon aculeatum, Tsukamurella paurometabola
-
Manually annotated by BRENDA team
Hasegawa, J
Purification, crystallization and some properties of beta-hydroxyisobutyrate dehydrogenase from candida rugosa IFO 0750
Agric. Biol. Chem.
45
2805-2814
1981
Candida rugosa
-
Manually annotated by BRENDA team
De Paul Marshall, V.; Sokatch, J.R.
Regulation of valine catabolism in Pseudomonas putida
J. Bacteriol.
110
1073-1081
1972
Pseudomonas putida
Manually annotated by BRENDA team
Robinson, W.G.; Coon, M.J.
The purification and properties of beta-hydroxyisobutyrate dehydrogenase
J. Biol. Chem.
225
511-521
1956
Sus scrofa
Manually annotated by BRENDA team
Hawes, J.W.; Crabb, D.W.; Chan, R.J.; Rougraff, P.M.; Paxton, R.; Harris, R.A.
Mammalien 3-hydroxyisobutyrate dehydrogenase
Methods Enzymol.
324
218-228
2000
Homo sapiens, Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Chowdhury, E.K.; Nagata, S.; Misono, H.
3-Hydroxyisobutyrate dehydrogenase from Pseudomonas putida E23: purification and characterization
Biosci. Biotechnol. Biochem.
60
2043-2047
1996
Candida rugosa, Oryctolagus cuniculus, Pseudomonas putida, Pseudomonas putida E23
Manually annotated by BRENDA team
Hawes, J.W.; Harper, E.T.; Crabb, D.W.; Harris, R.A.
Structural and mechanistic aspects of a new family of dehydrogenases, the beta-hydroxyacid dehydrogenases
Adv. Exp. Med. Biol.
414
395-402
1996
Rattus norvegicus
Manually annotated by BRENDA team
Chowdhury, E.K.; Akaishi, Y.; Nagata, S.; Misono, H.
Cloning and overexpression of the 3-hydroxyisobutyrate dehydrogenase gene from Pseudomonas putida E23
Biosci. Biotechnol. Biochem.
67
438-441
2003
Pseudomonas putida (Q76KL5), Pseudomonas putida E23, Pseudomonas putida E23 (Q76KL5)
Manually annotated by BRENDA team
Loupatty, F.J.; van der Steen, A.; Ijlst, L.; Ruiter, J.P.; Ofman, R.; Baumgartner, M.R.; Ballhausen, D.; Yamaguchi, S.; Duran, M.; Wanders, R.J.
Clinical, biochemical, and molecular findings in three patients with 3-hydroxyisobutyric aciduria
Mol. Genet. Metab.
87
243-248
2006
Homo sapiens
Manually annotated by BRENDA team
Murin, R.; Schaer, A.; Kowtharapu, B.S.; Verleysdonk, S.; Hamprecht, B.
Expression of 3-hydroxyisobutyrate dehydrogenase in cultured neural cells
J. Neurochem.
105
1176-1186
2008
Rattus norvegicus
Manually annotated by BRENDA team
Yao, T.; Xu, L.; Ying, H.; Huang, H.; Yan, M.
The catalytic property of 3-hydroxyisobutyrate dehydrogenase from Bacillus cereus on 3-hydroxypropionate
Appl. Biochem. Biotechnol.
160
694-703
2009
Bacillus cereus, Bacillus cereus ATCC 14579, Bacillus cereus ATCC14579
Manually annotated by BRENDA team
Tasi, Y.C.; Chao, H.C.; Chung, C.L.; Liu, X.Y.; Lin, Y.M.; Liao, P.C.; Pan, H.A.; Chiang, H.S.; Kuo, P.L.; Lin, Y.H.
Characterization of 3-hydroxyisobutyrate dehydrogenase, HIBADH, as a sperm-motility marker
J. Assist. Reprod. Genet.
30
505-512
2013
Homo sapiens
Manually annotated by BRENDA team
Park, S.C.; Kim, P.H.; Lee, G.S.; Kang, S.G.; Ko, H.J.; Yoon, S.I.
Structural and biochemical characterization of the Bacillus cereus 3-hydroxyisobutyrate dehydrogenase
Biochem. Biophys. Res. Commun.
474
522-527
2016
Bacillus cereus
Manually annotated by BRENDA team
Lee, P.; Raj, S.; Zhou, S.; Ashok, S.; Edwardraja, S.; Park, S.
3-Hydroxyisobutyrate dehydrogenase-I from Pseudomonas denitrificans ATCC 13867 degrades 3-hydroxypropionic acid
Biotechnol. Bioprocess Eng.
19
1-7
2014
Pseudomonas denitrificans, Pseudomonas denitrificans ATCC 13867
-
Manually annotated by BRENDA team
Zhou, S.; Mohan Raj, S.; Ashok, S.; Edwardraja, S.; Lee, S.G.; Park, S.
Cloning, expression and characterization of 3-hydroxyisobutyrate dehydrogenase from Pseudomonas denitrificans ATCC 13867
PLoS ONE
8
e62666
2013
Pseudomonas denitrificans, Pseudomonas denitrificans ATCC 13867
Manually annotated by BRENDA team