1.1.1.209: 3(or 17)alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 3(or 17)alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

androsterone
+
NAD(P)+
=
5alpha-androstane-3,17-dione
+
NAD(P)H
+
H+

Synonyms

3(17)alpha-hydroxysteroid dehydrogenase, AKR1C21, dehydrogenase, 3(17)alpha-hydroxy steroid, More

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.209 - 3(or 17)alpha-hydroxysteroid dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
17beta-estradiol
-
5 mM, 77% inhibition
5alpha-Androstan-3beta-ol-17-one
-
1 mM, 80% inhibition
5alpha-pregnan-3beta-ol-21-one
-
1 mM, 66% inhibition
5beta-androstan-3beta-ol-17-one
-
1 mM, 91% inhibition
5beta-Pregnan-3beta-ol-20-one
-
1 mM, 80% inhibition
androsterone
-
competitive vs. epitestosterone
Barbital
-
100 mM, 11% inhibition
chrysin
-
-
Dienstrol
-
1 mM, 22% inhibition
fidarestat
-
-
Hexestrol
-
1 mM, 77% inhibition
Hexoestrol
-
-
minalrestat
-
inhibition pattern for AKR1C21, overview
myricetin
-
-
quercetin
-
inhibition pattern for AKR1C21, overview
quercitrin
-
-
sorbinil
-
-
Stilbestrol
-
10 mM, 75% inhibition
testosterone
-
1 mM, 48% inhibition
Tolrestat
-
inhibition pattern for AKR1C21, overview
zopolrestat
-
-
additional information
-
enzyme-inhibitor complexe modelling, Tyr118 and Phe311 are important residues for inhibitor recognition and orientation in the active site of AKR1C21, overview
-