BRENDA - Enzyme Database show
show all sequences of 1.1.1.209

Identification of two dihydrodiol dehydrogenases associated with 3(17)alpha-hydoxysteroid dehydrogenase activity in mouse kidney

Nakagawa, M.; Tsukuda, F.; Nakayama, T.; Matsuura, K.; Hara, A.; Sawada, H.; J. Biochem. 106, 633-638 (1989)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
17beta-estradiol
5 mM, 77% inhibition
Mus musculus
5alpha-Androstan-3beta-ol-17-one
1 mM, 80% inhibition
Mus musculus
5alpha-pregnan-3beta-ol-21-one
1 mM, 66% inhibition
Mus musculus
5beta-androstan-3beta-ol-17-one
1 mM, 91% inhibition
Mus musculus
5beta-Pregnan-3beta-ol-20-one
1 mM, 80% inhibition
Mus musculus
Barbital
100 mM, 11% inhibition
Mus musculus
Dienstrol
1 mM, 22% inhibition
Mus musculus
Hexestrol
1 mM, 77% inhibition
Mus musculus
Stilbestrol
10 mM, 75% inhibition
Mus musculus
testosterone
1 mM, 48% inhibition
Mus musculus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0001
-
5beta-androstane-3alpha,17beta-diol
cofactor NADP+
Mus musculus
0.0001
-
Epitestosterone
cofactor NADP+
Mus musculus
0.0003
-
5beta-androstane-3alpha,17beta-diol
cofactor NADP+
Mus musculus
0.0004
-
glycolithocholic acid
cofactor NADP+
Mus musculus
0.0005
-
5beta-pregnane-3alpha,20alpha-diol
cofactor NADP+
Mus musculus
0.0007
-
5beta-pregnane-3alpha-ol-20-one
cofactor NADP+
Mus musculus
0.004
-
NADP+
-
Mus musculus
0.16
-
(R)-1-indanol
cofactor NADP+
Mus musculus
0.26
-
NAD+
-
Mus musculus
0.77
-
trans-benzene dihydrodiol
cofactor NADP+
Mus musculus
1.99
-
cis-benzene dihydrodiol
cofactor NADP+
Mus musculus
2.23
-
cyclohex-2-ene-1-ol
cofactor NADP+
Mus musculus
2.67
-
Naphthalene dihydrodiol
cofactor NADP+
Mus musculus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
34000
-
gel filtration
Mus musculus
39000
-
1 * 39000, SDS-PAGE
Mus musculus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
-
-
Purification (Commentary)
Commentary
Organism
Q-Sepharose, Matrex Red A, HA-Ultrogel, Sephadex G-100, two enzyme preparations DD1 and DD2 with almost identical properties, products of post-translational or post-mortem modification rather than isoenzymes
Mus musculus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
kidney
-
Mus musculus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
0.27
-
-
Mus musculus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(R)-1-indanol + NADP+
37% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
1-indanone + NADPH
-
286234
Mus musculus
?
(S)-1-indanole + NADP+
7% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
1-indanone + NADPH
-
286234
Mus musculus
?
1-acenaphthenol + NADP+
10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
1-acenaphthenone + NADPH
-
286234
Mus musculus
?
4-nitrobenzaldehyde + NADPH
58% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
4-nitrobenzyl alcohol + NADP+
-
286234
Mus musculus
?
5alpha-androstane-3alpha,17beta-diol + NADP+
7% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5alpha-androstane-17beta-ol-3-one + NADPH
-
286234
Mus musculus
?
5alpha-pregnan-3alpha,20alpha-diol + NADP+
6% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5alpha-pregnan-20alpha-ol-3-one + NADPH
-
286234
Mus musculus
?
5alpha-pregnan-3alpha,21-diol-20-one + NADP+
7% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5alpha-pregnan-21alpha-ol-3,20-dione + NADPH
-
286234
Mus musculus
?
5alpha-pregnane-21-ol-3,20-dione + NADPH
75% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5beta-pregnane-3alpha,21-diol-20-one + NADP+
-
286234
Mus musculus
?
5alpha-pregnane-3,20-dione + NADPH
10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5alpha-pregnane-3alpha-ol-20-one + NADP+
-
286234
Mus musculus
?
5beta-androstan-17beta-ol-3-one + NADPH
10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5beta-androstan-17beta,3alpha-diol + NADP+
-
286234
Mus musculus
?
5beta-androstane-3,17-dione + NADPH
10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5beta-androstan-3alpha-ol-17-one + NADP+
-
286234
Mus musculus
?
5beta-androstane-3alpha,17beta-diol + NADP+
11% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5beta-androstane-17beta-ol-3-one + NADPH
-
286234
Mus musculus
?
5beta-androstane-3alpha-ol-17-one + NADP+
9% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5beta-androstane-3,17-dione + NADPH
-
286234
Mus musculus
?
5beta-pregnan-3alpha,20alpha-diol + NADP+
26% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5beta-pregnan-3-one-20alpha-ol + NADPH
-
286234
Mus musculus
?
5beta-pregnan-3alpha-ol-20-one + NADP+
19% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5beta-pregnan-3,20-dione + NADPH
-
286234
Mus musculus
?
5beta-pregnane-3,20-dione + NADPH + H+
21% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5beta-pregnane-3alpha-ol-20-one + NADP+
-
286234
Mus musculus
?
acenaphthenequinone + NADPH
44% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
acenaphthenehydroquinone + NADP+
-
286234
Mus musculus
?
androst-4-ene-3,17-dione + NADPH
10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
androst-4-ene-3alpha-ol-17-one + NADP+
-
286234
Mus musculus
?
camphorquinone + NADPH + H+
52% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
camphorhydroquinone + NADP+
-
286234
Mus musculus
?
cis-1,2-dihydroxy-3,5-cyclohexadiene + NADP+
60% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
catechol + NADPH
-
286234
Mus musculus
?
cyclohex-2-ene-1-ol + NADP+
9% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
cyclohex-2-en-1-one + NADPH
-
286234
Mus musculus
?
cyclohexanone + NADPH
16% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
cyclohexanol + NADP+
-
286234
Mus musculus
?
epitestosterone + NADP+
11% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
testosterone + NADPH + H+
-
286234
Mus musculus
?
glycolithocholic acid + NADP+
56% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
dehydroglycolithocholic acid + NADPH
-
286234
Mus musculus
?
naphthalene dihydrodiol + NADP+
49% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
naphthacatechol + NADPH
-
286234
Mus musculus
?
pyridine-4-ol + NADP+
75% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
3H-pyridine-4-one + NADPH
-
286234
Mus musculus
?
trans-1,2-dihydroxy-3,5-cyclohexadiene + NADP+
-
286234
Mus musculus
catechol + NADPH
-
286234
Mus musculus
?
Subunits
Subunits
Commentary
Organism
monomer
1 * 39000, SDS-PAGE
Mus musculus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6
6.8
5beta-pregnane-3,20-dione as substrate, cofactor NADPH
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
17beta-estradiol
5 mM, 77% inhibition
Mus musculus
5alpha-Androstan-3beta-ol-17-one
1 mM, 80% inhibition
Mus musculus
5alpha-pregnan-3beta-ol-21-one
1 mM, 66% inhibition
Mus musculus
5beta-androstan-3beta-ol-17-one
1 mM, 91% inhibition
Mus musculus
5beta-Pregnan-3beta-ol-20-one
1 mM, 80% inhibition
Mus musculus
Barbital
100 mM, 11% inhibition
Mus musculus
Dienstrol
1 mM, 22% inhibition
Mus musculus
Hexestrol
1 mM, 77% inhibition
Mus musculus
Stilbestrol
10 mM, 75% inhibition
Mus musculus
testosterone
1 mM, 48% inhibition
Mus musculus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0001
-
5beta-androstane-3alpha,17beta-diol
cofactor NADP+
Mus musculus
0.0001
-
Epitestosterone
cofactor NADP+
Mus musculus
0.0003
-
5beta-androstane-3alpha,17beta-diol
cofactor NADP+
Mus musculus
0.0004
-
glycolithocholic acid
cofactor NADP+
Mus musculus
0.0005
-
5beta-pregnane-3alpha,20alpha-diol
cofactor NADP+
Mus musculus
0.0007
-
5beta-pregnane-3alpha-ol-20-one
cofactor NADP+
Mus musculus
0.004
-
NADP+
-
Mus musculus
0.16
-
(R)-1-indanol
cofactor NADP+
Mus musculus
0.26
-
NAD+
-
Mus musculus
0.77
-
trans-benzene dihydrodiol
cofactor NADP+
Mus musculus
1.99
-
cis-benzene dihydrodiol
cofactor NADP+
Mus musculus
2.23
-
cyclohex-2-ene-1-ol
cofactor NADP+
Mus musculus
2.67
-
Naphthalene dihydrodiol
cofactor NADP+
Mus musculus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
34000
-
gel filtration
Mus musculus
39000
-
1 * 39000, SDS-PAGE
Mus musculus
Purification (Commentary) (protein specific)
Commentary
Organism
Q-Sepharose, Matrex Red A, HA-Ultrogel, Sephadex G-100, two enzyme preparations DD1 and DD2 with almost identical properties, products of post-translational or post-mortem modification rather than isoenzymes
Mus musculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
kidney
-
Mus musculus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
0.27
-
-
Mus musculus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(R)-1-indanol + NADP+
37% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
1-indanone + NADPH
-
286234
Mus musculus
?
(S)-1-indanole + NADP+
7% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
1-indanone + NADPH
-
286234
Mus musculus
?
1-acenaphthenol + NADP+
10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
1-acenaphthenone + NADPH
-
286234
Mus musculus
?
4-nitrobenzaldehyde + NADPH
58% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
4-nitrobenzyl alcohol + NADP+
-
286234
Mus musculus
?
5alpha-androstane-3alpha,17beta-diol + NADP+
7% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5alpha-androstane-17beta-ol-3-one + NADPH
-
286234
Mus musculus
?
5alpha-pregnan-3alpha,20alpha-diol + NADP+
6% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5alpha-pregnan-20alpha-ol-3-one + NADPH
-
286234
Mus musculus
?
5alpha-pregnan-3alpha,21-diol-20-one + NADP+
7% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5alpha-pregnan-21alpha-ol-3,20-dione + NADPH
-
286234
Mus musculus
?
5alpha-pregnane-21-ol-3,20-dione + NADPH
75% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5beta-pregnane-3alpha,21-diol-20-one + NADP+
-
286234
Mus musculus
?
5alpha-pregnane-3,20-dione + NADPH
10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5alpha-pregnane-3alpha-ol-20-one + NADP+
-
286234
Mus musculus
?
5beta-androstan-17beta-ol-3-one + NADPH
10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5beta-androstan-17beta,3alpha-diol + NADP+
-
286234
Mus musculus
?
5beta-androstane-3,17-dione + NADPH
10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5beta-androstan-3alpha-ol-17-one + NADP+
-
286234
Mus musculus
?
5beta-androstane-3alpha,17beta-diol + NADP+
11% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5beta-androstane-17beta-ol-3-one + NADPH
-
286234
Mus musculus
?
5beta-androstane-3alpha-ol-17-one + NADP+
9% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5beta-androstane-3,17-dione + NADPH
-
286234
Mus musculus
?
5beta-pregnan-3alpha,20alpha-diol + NADP+
26% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5beta-pregnan-3-one-20alpha-ol + NADPH
-
286234
Mus musculus
?
5beta-pregnan-3alpha-ol-20-one + NADP+
19% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5beta-pregnan-3,20-dione + NADPH
-
286234
Mus musculus
?
5beta-pregnane-3,20-dione + NADPH + H+
21% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
5beta-pregnane-3alpha-ol-20-one + NADP+
-
286234
Mus musculus
?
acenaphthenequinone + NADPH
44% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
acenaphthenehydroquinone + NADP+
-
286234
Mus musculus
?
androst-4-ene-3,17-dione + NADPH
10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
androst-4-ene-3alpha-ol-17-one + NADP+
-
286234
Mus musculus
?
camphorquinone + NADPH + H+
52% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
camphorhydroquinone + NADP+
-
286234
Mus musculus
?
cis-1,2-dihydroxy-3,5-cyclohexadiene + NADP+
60% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
catechol + NADPH
-
286234
Mus musculus
?
cyclohex-2-ene-1-ol + NADP+
9% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
cyclohex-2-en-1-one + NADPH
-
286234
Mus musculus
?
cyclohexanone + NADPH
16% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
cyclohexanol + NADP+
-
286234
Mus musculus
?
epitestosterone + NADP+
11% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
testosterone + NADPH + H+
-
286234
Mus musculus
?
glycolithocholic acid + NADP+
56% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
dehydroglycolithocholic acid + NADPH
-
286234
Mus musculus
?
naphthalene dihydrodiol + NADP+
49% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
naphthacatechol + NADPH
-
286234
Mus musculus
?
pyridine-4-ol + NADP+
75% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
286234
Mus musculus
3H-pyridine-4-one + NADPH
-
286234
Mus musculus
?
trans-1,2-dihydroxy-3,5-cyclohexadiene + NADP+
-
286234
Mus musculus
catechol + NADPH
-
286234
Mus musculus
?
Subunits (protein specific)
Subunits
Commentary
Organism
monomer
1 * 39000, SDS-PAGE
Mus musculus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6
6.8
5beta-pregnane-3,20-dione as substrate, cofactor NADPH
Mus musculus
Other publictions for EC 1.1.1.209
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [░C]
Temperature Range [░C]
Temperature Stability [░C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [░C] (protein specific)
Temperature Range [░C] (protein specific)
Temperature Stability [░C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
710716
Dhagat
Studies on a Tyr residue criti ...
Mus musculus
Acta Crystallogr. Sect. D
66
198-204
2010
-
-
-
1
3
-
-
36
-
-
-
-
-
2
-
-
-
-
-
-
-
-
12
-
-
-
-
38
-
-
-
-
-
-
-
-
-
-
-
1
3
-
-
-
-
36
-
-
-
-
-
-
-
-
-
-
-
-
12
-
-
-
-
38
-
-
-
-
-
-
-
-
36
36
695325
Dhagat
Structure of the G225P/G226P m ...
Mus musculus
Acta Crystallogr. Sect. D
65
257-265
2009
-
-
1
1
1
-
1
16
-
-
-
-
-
2
-
-
1
-
-
-
-
-
10
-
-
-
-
16
-
-
-
1
-
-
2
-
-
1
1
1
1
-
2
1
-
16
-
-
-
-
-
-
-
1
-
-
-
-
10
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
685538
Dhagat
Inhibition of 3(17)alpha-hydro ...
Mus musculus
Bioorg. Med. Chem.
16
3245-3254
2008
-
-
-
-
-
-
10
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
9
-
-
-
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