1.1.1.209: 3(or 17)alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 3(or 17)alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

androsterone
+
NAD(P)+
=
5alpha-androstane-3,17-dione
+
NAD(P)H
+
H+

Synonyms

3(17)alpha-hydroxysteroid dehydrogenase, AKR1C21, dehydrogenase, 3(17)alpha-hydroxy steroid, More

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase

KM Value

KM Value on EC 1.1.1.209 - 3(or 17)alpha-hydroxysteroid dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.019
(2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide
-
-
0.16
(R)-1-indanol
-
cofactor NADP+
0.0002 - 0.0078
4-androstene-3,17-dione
0.0004 - 0.014
5alpha-Androstan-17alpha-ol-3-one
0.0047 - 0.096
5alpha-androstan-17beta-ol-3-one
0.0006 - 0.015
5alpha-Androstan-3alpha-ol-17-one
0.013 - 0.1
5alpha-androstan-3beta,17beta-diol
0.026
5alpha-dihydrotestosterone
-
-
0.0005 - 0.08
5alpha-pregnane-3alpha,20alpha-diol
0.0004 - 0.0013
5beta-androstan-17alpha-ol-3-one
0.0001 - 0.0003
5beta-androstane-3alpha,17beta-diol
0.0002 - 0.015
5beta-pregnane-20alpha-ol-3-one
0.0004 - 0.0059
5beta-pregnane-3,20-dione
0.0005 - 0.018
5beta-pregnane-3alpha,20alpha-diol
0.0007
5beta-pregnane-3alpha-ol-20-one
-
cofactor NADP+
0.0012 - 0.048
androsterone
1.99
cis-benzene dihydrodiol
-
cofactor NADP+
2.23
cyclohex-2-ene-1-ol
-
cofactor NADP+
0.0001 - 0.02
Epitestosterone
0.0004
glycolithocholic acid
-
cofactor NADP+
0.0001 - 0.0067
lithocholic acid
0.26
NAD+
-
-
0.004
NADP+
-
-
2.67
Naphthalene dihydrodiol
-
cofactor NADP+
0.012 - 0.023
testosterone
0.77
trans-benzene dihydrodiol
-
cofactor NADP+