1.1.1.209: 3(or 17)alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 3(or 17)alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

androsterone
+
NAD(P)+
=
5alpha-androstane-3,17-dione
+
NAD(P)H
+
H+

Synonyms

3(17)alpha-hydroxysteroid dehydrogenase, AKR1C21, dehydrogenase, 3(17)alpha-hydroxy steroid, More

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.209 - 3(or 17)alpha-hydroxysteroid dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-1-indanol + NADP+
1-indanone + NADPH
show the reaction diagram
-
37% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
(S)-1-indanole + NADP+
1-indanone + NADPH
show the reaction diagram
-
7% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
1-acenaphthenol + NADP+
1-acenaphthenone + NADPH
show the reaction diagram
-
10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
17alpha-estradiol + NAD(P)+
estrone + NAD(P)H
show the reaction diagram
17alpha-estradiol 3-glucuronide + NAD(P)+
estrone 3-glucuronide + NAD(P)H
show the reaction diagram
21-hydroxy-5beta-pregnane-3,20-dione + NADPH
21-hydroxy-5beta-pregnane-20alpha-ol-3-one + NADP+
show the reaction diagram
-
-
-
r
3alpha-androstanediol + NAD(P)+
androsterone + NAD(P)H
show the reaction diagram
-
-
-
r
3alpha-hydroxy-5alpha-androstan-17-one + NAD(P)+
5alpha-androstan-3,17-dione + NAD(P)H
show the reaction diagram
4-androstene-3,17-dione + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
4-androstene-3,17-dione + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
r
4-nitrobenzaldehyde + NADPH
4-nitrobenzyl alcohol + NADP+
show the reaction diagram
-
58% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
5-androstene-3beta,17beta-diol + NADP+
? + NADPH
show the reaction diagram
-
no substrate for wild-type, but substrate for mutants Y224F, Y224D, Q222D
-
-
?
5alpha-androstan-17alpha-ol-3-one + NADP+
5alpha-androstan-3,17-dione + NADPH + H+
show the reaction diagram
-
-
-
-
?
5alpha-androstan-17alpha-ol-3-one + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
?
5alpha-androstan-17beta-ol-3-one + NADP+
5alpha-androstan-3,17-dione + NADPH + H+
show the reaction diagram
5alpha-androstan-3alpha,17beta-diol + NAD(P)+
17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H
show the reaction diagram
5alpha-androstan-3alpha-ol-17-one + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
5alpha-androstan-3alpha-ol-17-one + NADPH + H+
5alpha-androstan-3alpha-ol-17beta-ol + NADP+
show the reaction diagram
-
-
-
-
?
5alpha-androstan-3beta,17beta-diol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
?
5alpha-androstan-3beta,17beta-diol + NADP+
? + NADPH + H+
show the reaction diagram
-
-
-
-
?
5alpha-androstane-3alpha,17beta-diol + NADP+
5alpha-androstane-17beta-ol-3-one + NADPH
show the reaction diagram
-
7% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
5alpha-dihydrotestosterone + NAD(P)H
androstanedione + NAD(P)+
show the reaction diagram
-
-
-
r
5alpha-pregnan-3alpha,20alpha-diol + NADP+
5alpha-pregnan-20alpha-ol-3-one + NADPH
show the reaction diagram
-
6% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
5alpha-pregnan-3alpha,21-diol-20-one + NADP+
5alpha-pregnan-21alpha-ol-3,20-dione + NADPH
show the reaction diagram
-
7% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
5alpha-pregnane-21-ol-3,20-dione + NADPH
5beta-pregnane-3alpha,21-diol-20-one + NADP+
show the reaction diagram
-
75% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
5alpha-pregnane-3,20-dione + NADPH
5alpha-pregnane-3alpha-ol-20-one + NADP+
show the reaction diagram
-
10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
5alpha-pregnane-3alpha,20alpha-diol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
?
5beta-androstan-17alpha-ol-3-one + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
?
5beta-androstan-17beta-ol-3-one + NADPH
5beta-androstan-17beta,3alpha-diol + NADP+
show the reaction diagram
-
10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
5beta-androstane-3,17-dione + NADPH
5beta-androstan-3alpha-ol-17-one + NADP+
show the reaction diagram
-
10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
5beta-androstane-3alpha,17beta-diol + NADP+
5beta-androstane-17beta-ol-3-one + NADPH
show the reaction diagram
-
11% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
5beta-androstane-3alpha-ol-17-one + NADP+
5beta-androstane-3,17-dione + NADPH
show the reaction diagram
-
9% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
5beta-pregnan-3alpha,20alpha-diol + NADP+
5beta-pregnan-3-one-20alpha-ol + NADPH
show the reaction diagram
-
26% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
5beta-pregnan-3alpha-ol-20-one + NADP+
5beta-pregnan-3,20-dione + NADPH
show the reaction diagram
-
19% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
5beta-pregnane-20alpha-ol-3-one + NADP+
5beta-pregnane-3alpha,20alpha-diol + NADPH + H+
show the reaction diagram
-
-
-
-
r
5beta-pregnane-3,20-dione + NADPH + H+
5beta-pregnane-3alpha-ol-20-one + NADP+
show the reaction diagram
5beta-pregnane-3alpha,20alpha-diol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
?
5beta-pregnane-3alpha,20alpha-diol + NADPH + H+
5beta-pregnane-20alpha-ol-3-one + NADP+
show the reaction diagram
acenaphthenequinone + NADPH
acenaphthenehydroquinone + NADP+
show the reaction diagram
-
44% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
androst-4-ene-3,17-dione + NADPH
androst-4-ene-3alpha-ol-17-one + NADP+
show the reaction diagram
-
10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
androstenedione + NADPH + H+
androsterone + NADP+
show the reaction diagram
-
-
-
r
camphorquinone + NADPH + H+
camphorhydroquinone + NADP+
show the reaction diagram
-
52% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
cis-1,2-dihydroxy-3,5-cyclohexadiene + NADP+
catechol + NADPH
show the reaction diagram
-
60% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
cyclohex-2-ene-1-ol + NADP+
cyclohex-2-en-1-one + NADPH
show the reaction diagram
-
9% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
cyclohexanone + NADPH
cyclohexanol + NADP+
show the reaction diagram
-
16% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
epitestosterone
? + NADPH
show the reaction diagram
-
-
-
-
?
epitestosterone + NAD(P)+
androst-4-en-3,17-dione + NAD(P)H + H+
show the reaction diagram
epitestosterone + NADP+
testosterone + NADPH + H+
show the reaction diagram
estrone 3-sulfate + NAD(P)H
17alpha-estradiol 3-sulfate + NAD(P)+
show the reaction diagram
-
-
-
?
glycolithocholic acid + NADP+
dehydroglycolithocholic acid + NADPH
show the reaction diagram
-
56% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
lithocholic acid + NADP+
? + NADPH + H+
show the reaction diagram
-
-
-
-
r
naphthalene dihydrodiol + NADP+
naphthacatechol + NADPH
show the reaction diagram
-
49% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
pyridine-4-ol + NADP+
3H-pyridine-4-one + NADPH
show the reaction diagram
-
75% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
-
?
testosterone + NAD(P)+
androstenedione + NAD(P)H + H+
show the reaction diagram
-
-
-
?
testosterone + NADP+
androst-4-en-3,17-dione + NADPH + H+
show the reaction diagram
-
mutant G225P/G226P, wild-type shows no activity with testosterone
-
-
?
trans-1,2-dihydroxy-3,5-cyclohexadiene + NADP+
catechol + NADPH
show the reaction diagram
-
-
-
?
additional information
?
-